| A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia (2009) | |||||||||||||
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| Background: Smoking may affect the efficacy of chemotherapy and the incidence of adverse events. We investigated the correlation between smoking history and gemcitabine-induced neutropenia. Patients and methods: Data on smoking history and incidence of grade 3–4 neutropenia were retrospectively gathered for 103 chemo-naive patients treated with gemcitabine monotherapy (59 patients with pancreatic, 41 with hepatobiliary and three with other cancers). Results: There was a significantly higher incidence of grade 3–4 neutropenia among patients without a history of smoking (55.7%) than among those with a history of smoking (including current and ex-smokers; 23.6%) [odds ratio (OR) 0.244, 95% confidence interval (CI) 0.105–0.569; P | |||||||||||||
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