| High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers (2009) | |||||||||||||
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| Many genome-wide assays involve the generation of a subset (or representation) of the genome following restriction enzyme digestion. The use of enzymes sensitive to cytosine methylation allows high-throughput analysis of this epigenetic regulatory process. We show that the use of a dual-adapter approach allows us to generate genomic representations that includes fragments of | |||||||||||||
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