| RAPID COMMUNICATION: TIANEPTINE, A SPECIFIC SEROTONIN UPTAKE ENHANCER, DECREASES ETHANOL INTAKE IN RATS (1992) | |||||||||||||
Abstract | |||||||||||||
| The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function. | |||||||||||||
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