| Multiple ADH genes modulate risk for drug dependence (2006) | |||||||||||||
Abstract | |||||||||||||
| Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with seven ADH genes. The present study examines the relationship between these genes and DD. We genotyped 16 markers within the ADH gene cluster and 38 unlinked ancestry-informative markers in a case-control sample of 718 individuals. All markers were consistent with Hardy-Weinberg Equilibrium in controls, but some markers showed Hardy-Weinberg Disequilibrium in cases (minimal p=0.002). Genotypes of many markers were associated with DD, both before and after controlling for admixture effects (minimal p | |||||||||||||
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