| CARDIOVASCULAR EFFECTS OF ISOETHARINE ADMINISTERED TO SURGICAL PATIENTS DURING CYCLOPROPANE ANAESTHESIA (1970) | |||||||||||||
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| Isoetharine was administered intravenously in doses ranging from 1 to 15 μg/kg to fourteen patients undergoing elective surgery during cyclopropane anaesthesia. In all cases isoetharine caused a decrease in systolic and diastolic arterial pressures and an increase in heart rate. These effects were dose-related, with a dose response plateau occurring between 5 and 10 μg/kg. Variable displacement of the cardiac pacemaker to the AV node occurred. However, in no instances did premature ventricular contractions appear. It is concluded that isoetharine is a safe drug to be administered intravenously during inhalation anaesthesia with cyclopropane. | |||||||||||||
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