| A second major histocompatibility complex susceptibility locus for multiple sclerosis (2007) | |||||||||||||
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Abstract | |||||||||||||
| Objective: Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HL4-DPB1 gene in the class 11 region. The possibility that other genes in the MHC independently influence susceptibility to multiple sclerosis has been suggested but remains unconfirmed.. This study was supported by the following awards: Wellcome Trust Prize Studentship (T.W.Y.), St. Edmund’s College(T.W.Y.), Cambridge Commonwealth Trust and Cambridge Philosophical Society (T.W.Y.), the William C. Fowler scholarship in Multiple Sclerosis (P.L.D.), the National Institutes of Health (K08 NS46341, P.L.D.; NS049477, S.L.H.; NS026799, S.L.H.; NS032830, J.L.H., M.A.PV.), a GlaxoSmithKline Clinical Fellowship (S.S.), a Postdoctoral Fellowship of the Research Foundation–Flanders (FWO–Vlaanderen, A.G.), a European Neurological Society fellowship (C.F.), Cancer Research Institute fellowship (E.W.), the Medical Research Council (United Kingdom) (G0000648, A.C.), the Wellcome Trust (048880 and 057097, A.C.), a National Multiple Sclerosis Society Center Grant (AP 3758-A-16, D.A.H., A.J.I), and The Penates Foundation (D.A.H., A.J.I.). | |||||||||||||
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