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ChIP-chip: Data, Model, and Analysis (2005)

Abstract

ChIP-chip (or ChIP-on-chip) is a technology for isolation and identification of genomic sites occupied by specific DNA binding proteins in living cells. The ChIP-chip data can be obtained over the whole genome by tiling arrays, where a peak in the signal is generally observed at a protein binding site. In this paper, we describe and present a probability theory for modelling ChIP-chip data. We then propose a model-based computa- tional method for locating and testing peaks for the purpose of identifying potential protein binding sites.

Publication details

Download	http://repositories.cdlib.org/uclastat/papers/2005102801
Publisher	eScholarship Repository, Department of Statistics, UCLA, University of California, Los Angeles
Repository	University of California eScholarship Repository (United States)
Keywords	enome, Mpeak, Peak detection, Protein binding sites, Sonication, Truncated triangle shape model
Type	text

Cited publications (2)

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