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The complete sequence of human chromosome 5 (2004) |
- Schmutz, Jeremy,
- Martin, Joel,
- Terry, Astrid,
- Couronne, Olivier,
- Grimwood, Jane,
- Lowry, State,
- Gordon, Laurie A.,
- Scott, Duncan,
- Xie, Gary,
- Huang, Wayne,
- Hellsten, Uffe,
- Tran-Gyamfi, Mary,
- She, Xinwei,
- Prabhakar, Shyam,
- Aerts, Andrea,
- Altherr, Michael,
- Bajorek, Eva,
- Black, Stacey,
- Branscomb, Elbert,
- Caoile, Chenier,
- Challacombe, Jean F.,
- Chan, Yee Man,
- Denys, Mirian,
- Detter, Chris,
- Escobar, Julio,
- Flowers, Dave,
- Fotopulos, Dea,
- Glavina, Tijana,
- Gomez, Maria,
- Gonzales, Eidelyn,
- Goodstenin, David,
- Grigoriev, Igor,
- Groza, Matthew,
- Hammon, Nancy,
- Hawkins, Trevor,
- Haydu, Lauren,
- Israni, Sanjay,
- Jett, Jamie,
- Kadner, Kristen,
- Kimbal, Heather,
- Kobayashi, Arthur,
- Lopez, Frederick,
- Lou, Yunian,
- Martinez, Diego,
- Medina, Catherine,
- Morgan, Jenna,
- Nandkeshwar, Richard,
- Noonan, James P.,
- Pitluck, Sam,
- Pollard, Martin,
- Predki, Paul,
- Priest, James,
- Ramirez, Lucia,
- Rash, Sam,
- Retterer, James,
- Rodriguez, Alex,
- Rogers, Stephanie,
- Salamov, Asaf,
- Salazar, Angelica,
- Thayer, Nina,
- Tice, Hope,
- Tsai, Ming,
- Ustaszewska, Anna,
- Vo, Nu,
- Wheeler, Jeremy,
- Wu, Kevin,
- Yang, Joan,
- Dickson, Mark,
- Cheng, Jan-Fang,
- Eichler, Evan E.,
- Olsen, Anne,
- Pennacchio, Len A.,
- Rokhsar, Daniel S.,
- Richardson, Paul,
- Lucas, Susan M.,
- Myers, Richard M.,
- Rubin, Edward M.
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Abstract |
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Chromosome 5 is one of the largest human chromosomes yet has one of the lowest gene densities. This is partially explained by numerous gene-poor regions that display a remarkable degree of noncoding and syntenic conservation with non-mammalian vertebrates, suggesting they are functionally constrained. In total, we compiled 177.7 million base pairs of highly accurate finished sequence containing 923 manually curated protein-encoding genes including the protocadherin and interleukin gene families and the first complete versions of each of the large chromosome 5 specific internal duplications. These duplications are very recent evolutionary events and play a likely mechanistic role, since deletions of these regions are the cause of debilitating disorders including spinal muscular atrophy (SMA). |
Publication details |
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Publications citing this publication (1) |
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Cited publications (9) |
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Molecular mechanisms governing Pcdh-γ gene expression: Evidence for a multiple promoter and cis-alternative splicing model
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Extensive Linkage Disequilibrium, a Common 16.7-Kilobase Deletion, and Evidence of Balancing Selection in the Human Protocadherin α Cluster
- Noonan, James P. ,
- Li, Jun ,
- Nguyen, Loan ,
- Caoile, Chenier ,
- Dickson, Mark ,
- Grimwood, Jane ,
- Schmutz, Jeremy ,
- Feldman, Marcus W. ,
- Myers, Richard M.
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Large-Scale Variation Among Human and Great Ape Genomes Determined by Array Comparative Genomic Hybridization
- Locke, Devin P.,
- Segraves, Richard,
- Carbone, Lucia,
- Archidiacono, Nicoletta,
- Albertson, Donna G.,
- Pinkel, Daniel,
- Eichler, Evan E.
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International Chicken Genome Sequencing Consortium. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution (2004)
- Hillier, L.W.,
- Miller, W.,
- Birney, E.,
- Warren, W.,
- Hardison, R.C.,
- Groenen, M.A.M.
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A consensus linkage map of the chicken genome (1999)
- Groenen, M.A.M.,
- Cheng, H.H.,
- Bumstead, N.,
- Benkel, B.,
- Briles, E.,
- Burt, D.W.,
- Burke, T.,
- Dodgson, J.,
- Hillel, J.,
- Lamont, S.
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Comparative Genome Analysis Delimits a Chromosomal Domain and Identifies Key Regulatory Elements in the ... Globin Cluster (2001)
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Sequence Mapping by Electronic PCR
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Millions of Years of Evolution Preserved: A Comprehensive Catalog of the Processed Pseudogenes in the Human Genome
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LAGAN and Multi-LAGAN: Efficient Tools for Large-Scale Multiple Alignment of Genomic DNA
- Brudno, Michael,
- Do, Chuong B.,
- Cooper, Gregory M.,
- Kim, Michael F.,
- Davydov, Eugene,
- Program, NISC Comparative Sequencing,
- Green, Eric D.,
- Sidow, Arend,
- Batzoglou, Serafim
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