| Perceptual and semantic contributions to episodic memory: Evidence form semantic dementia and Alzheimer's disease (2002) | |||||||||||
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| Journal Memory and Language Journal Memory and Language www academicpress com Perceptual and semantic contributions episodic memory evidence from semantic dementia and Alzheimer disease Jon Simons Kim Graham and John Hodgesa MRC Cognition and Brain Sciences Unit Cambridge University Neurology Unit Addenbrooke Hospital Cambridge Received March revision received August Abstract Previous group studies involving patients with semantic dementia who have impaired semantic memory associated with temporal lobe atrophy have documented the preservation pictorial recognition memory contrast patients with early Alzheimer disease who characteristically exhibit amnesia The present study replicated this general pattern although four the semantic dementia patients with the most severe semantic deficit additionally had impaired recognition memory Three factors that might contribute this pattern memory performance were examined atrophic damage medial temporal lobe regions degradation semantic representations and disruption visuoperceptual processes Assessment MRI scans revealed that atrophy affecting the perirhinal cortex region accurately predicted the recognition memory deficit seen advanced stages semantic dementia but there was evidence that could attributed directly either degraded semantic knowledge disrupted perceptual processing Alzheimer disease evidence suggested that visuoperceptual impairment might involved the poor recognition memory typically seen the disorder These results have | |||||||||||
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Cited publications (3) | |||||||||||