| Impairment of specific episodic memory processes by sub-psychotic doses of ketamine: The effects of levels of processing at encoding and of the subsequent retrieval task (2005) | |||||||||||
|
|||||||||||
Abstract | |||||||||||
| Psychopharmacology DOI ORIGINA VESTI GATION Garry Honey Rebekah Honey Sam Sharar Danielle Turner Edith Pomarol Clotet Dharshan Kumaran Jon Simons Xiangen Michael Rugg Edward Bullmore Paul Fletcher Impairment specific episodic memory processes sub psychotic doses ketamine the effects levels processing encoding and the subsequent retrieval task Received April Accepted July Published online June Springer Verlag Abstract Rationale The precise nature the impact the methyl aspartate antagonist ketamine upon human episodic memory has yet elucidated fully Objectives This study sought assess the effects ketamine the sub processes facilitating memory encoding and retrieval Methods evaluated the effects the drug series memory performance measures depending upon whether was administered the encoding retrieval stage and the nature the encoding task used Twelve healthy volunteers participated double blind placebo controlled randomized within subjects study Intravenous infusions placebo ketamine ketamine were administered investigated the effects ketamine three key aspects episodic memory enG Honey Honey Turner Pomarol Clotet Kumaran Bullmore Fletcher Department Psychiatry University Cambridge Addenbrooke Hospital Box Hills Road Cambridge mail pcf cam Tel Fax Sharar Department Anesthesiology University Washington Harborview Medical Center Seattle USA Simons University College London London X Department Psychology University Memphis Memphis USA Rugg Center for Neurobiology Learning and Memor | |||||||||||
Publication details | |||||||||||
| |||||||||||