| Anaplastic large cell lymphoma with ALK expression and presence of the t(2;5) translocation in a 5-month-old infant (2005) | |||||||||
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Abstract | |||||||||
| Anaplastic large cell lymphoma ( ALCL) is a well- recognized subtype of non- Hodgkin lymphoma in childhood. Several series report experience with the diagnosis and management of pediatric ALCL, the average age at diagnosis being 8 to 16 years, with a reported range of 1 to 15 years. We present a case of ALCL affecting a 5- month- old infant in whom the diagnosis was confirmed by the nuclear and cytoplasmic immunohistochemical expression of ALK1, in addition to the presence of classical t( 2; 5)( p23; q35) translocation detected using reverse transcriptase- polymerase chain reaction. This is the youngest case of ALCL thus far reported and hence expands the spectrum of infantile lymphoproliferative disorders | |||||||||
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