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Is anoxic depolarisation associated with an ADC threshold? A Markov chain Monte Carlo analysis (2005)

King,
M.D.,
Crowder,
M.J.,
Hand,
D.J.,
Harris,
N.G.,
Williams,
S.R.,
Obrenovitch,
T.P.,
Gadian,
D.G.

Abstract

A Bayesian nonlinear hierarchical random coefficients model was used in a reanalysis of a previously published longitudinal study of the extracellular direct current (DC)-potential and apparent diffusion coefficient (ADC) responses to focal ischaemia. The main purpose was to examine the data for evidence of an ADC threshold for anoxic depolarisation. A Markov chain Monte Carlo simulation approach was adopted. The Metropolis algorithm was used to generate three parallel Markov chains and thus obtain a sampled posterior probability distribution for each of the DC-potential and ADC model parameters, together with a number of derived parameters. The latter were used in a subsequent threshold analysis. The analysis provided no evidence indicating a consistent and reproducible ADC threshold for anoxic depolarisation. Copyright (c) 2005 John Wiley & Sons, Ltd

Publication details

Download	http://www.ucl.ac.uk/research/publications/?action=search&pubid=107026
Repository	UCL Research Publications Index (MyOPIA) (United Kingdom)
Keywords	central nervous system, ischaemia, apparent diffusion coefficient threshold, anoxic depolarisation, Markov,2005, A, ADC, Analysis, AND, c, Chain, DIFFUSION, FOR, IS, ISCHAEMIA, Longitudinal, Longitudinal Studies, longitudinal study, Markov chain, Markov Chains, MODEL, Monte Carlo, NO, NO EVIDENCE, NUMBER, OF, Probability, PUBLISHED, RESPONSES, simulation, SUBSEQUENT, THE, threshold
Type	JOUR
Relation	587-594