| Effects of anisotropy on the development of cardiac arrhythmias associated with focal activity (2000) | |||||||||
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| Pfl gers Arch Eur Physiol DOI G L C Ronald Wilders Mary Wagner David Golod Rajiv Kumar Yang Gan Wang William Goolsby Ronald Joyner Habo Jongsma Effects anisotropy the development cardiac arrhythmias associated with focal activity Received May Received after revision July Accepted July Published online September Springer Verlag Abstract The anisotropy that normally exists the myocardium may either enhanced peri infarction zones loss lateral cell connections reduced redistribution gap junctions test how the degree anisotropy affects the development ectopic focal activity carried out computer simulations which model ectopic focus incorporated the central element two dimensional sheet ventricular cells low values intercellular coupling conductance the focus region spontaneously active but the limited intercellular current flow inhibits propagation high automaticity suppressed the loading effects the surrounding cells intermediate the ectopic activity may propagate into the sheet the case isotropic coupling the minimum size the focus region for propagation occur terms number collaborating cells within the focus small approximately ten cells and this number decreases with increasing anisotropy Thus the presence anisotropy facilitates the development ectopic focal activity conclude that the remodeling that occurs peri infarction zones may create substrate that either facilitates enhanced anisotropy inhibits reduced anisotropy the development cardiac arrhythmias associated with ectop | |||||||||
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