| Long-term regional specific changes in [3H]flunitrazepam binding in the kindled rat hippcampus (1995) | |||||||
Abstract | |||||||
| Neuroscience Vol pp Pra egmn Elsevier Science Ltd Copyright IBRO Printed Great Britain All rights reserved LONG TERM REGIONAL SPECIFIC CHANGES FLUNITRAZEPAM D IN D RAT HIPPOCAMPUS I A K H and O D SILVA Graduate School for the Neurosciences Institute Neurobiology Faculty Biology University Amsterdam Kruislaan Amsterdam The Netherlands Abstract The binding the GABAA benzodiazepine receptor agonist flunitrazepam was studied the hippocampus rats kindled daily stimulation the Schaffer collaterals using semi quantitative autoradiography Two kindled stages were investigated h after the last generalized tonic clonic seizure fully kindled and days after the last generalized seizure long term The binding flunitrazepam was determined two concentrations and the area found small but significant decrease both the and flunitrazepam binding the fully kindled stage contrast there was significant increase the binding the long term stage The binding was not significantly different from control binding this stage the granular and molecular layers the fascia dentata found both kindled stages significantly increased and respectively and and respectively binding Furthermore found that muscimol was still able enhance the flunitrazepam binding kindled animals indicating that the GABAA receptor agonist binding site and benzodiazepine agonist binding site are still functionally coupled The changes flunitrazepam binding the fully kindled stage are agreement with the recently observed kindling induced ch | |||||||
Publication details | |||||||
| |||||||