| Isozyme specific changes in the expression of protein kinase C isozyme (alpha - ) genes in the hippocampus of rats induced by kindling epileptogenesis (1995) | |||||||
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| BRAIN RESEARCH ELSEVIER Brain Research Research report Isozyme specific changes the expression protein kinase isozyme genes the hippocampus rats induced kindling epileptogenesis Willem Kamphuis Erik Hendriksen Fernando Lopes Silva Graduate School for the Neurosciences Institute Neurobiology Unicersily Amsterdam Kruislaan Amsterdam The Netherlands Accepted July Abstract The transcript levels the protein kinase PKC isoform genes during the development kindled epileptogenic focus elicited stimulation Schaffer collateral commissural fibres the area the rat hippocampus were compared with the expression levels control animals using semi quantitative situ hybridization approach the hippocampus control animals the levels PKC transcripts showed gene specific expression pattern and significant differences expression level were observed between the neurons and fascia dentata the early stages kindling epileptogenesis following and afterdischarges specific changes the expression levels PKC and but not PKC and were found PKC expression was decreased while the PKC and specific hybridization signals were increased CAI and fascia dentata fully kindled animals that had experienced generalized seizures most expression levels tended return control values One month after the last seizure significant alterations were encountered These results indicate involvement specific PKC isoform gene expression the induction epileptogenic focus but not the maintenance the long lasting kindled state Keywords P | |||||||
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