| GABA-A receptor beta 1-3 subunit gene expression in the hippocampus of kindled rats. (1994) | |||||||
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| ELSEVIER Neuroscience Letters UROSClEHCE LETTERS GABAA receptor subunit gene expression the hippocampus kindled rats Kamphuis Rijk Lopes Silva Graduate School for the Neurosciences University Amsterdam Institute Neurobiology Kruislaan Amsterdam The Netherlands Received February Revised version received April Accepted April Abstract The effect Schaffer collateral commissural fiber kindling the expression levels GABAA receptor ill fiE and subunit mRNA the pyramidal and granular neurons the rat dorsal hippocampus was studied using semi quantitative situ hybridization pyramidal neurons and only small changes were found dentate granule neurons the expression level GABAAR mRNA was significantly enhanced bilaterally animals that were partial fully kindled long term weeks after the last convulsion significant changes were found pyramidal granular neurons Key words Kindling GABAA receptor subunit Aminobutyric acid mRNA Hybridization situ Hippocampus Fascia dentata Epileptogenesis The repeated application high frequency electrical stimulation discrete regions the brain results the occurrence epileptiform afterdischarges increasing duration and intensity and the gradual appearance behavioural epileptiform seizure activity This process epileptogenesis called kindling leads long lasting increased seizure susceptibility and has been extensively studied experimental model focal epilepsy previous work have reported several changes that take place the GABAergic inhibitory system the hippocamp | |||||||
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