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Characterization of 10 New Polymorphic Dinucleotide Repeats and Generation of a High-Density Microsatellite-Based Physical Map of the BRCA1 Region of Chromosome 17q21 (1994)

Abstract

A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78 region were isolated and characterized. These markers, along with previously published markers from the region, were localized on a physical map by STS content mapping of cosmids from the BRCA1 interval. This high-density STS map of the BRCA1 region will be useful for linkage studies of families with apparent inherited breast cancer and for loss of heterozygosity analysis of breast tumor DNAs.. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/31157/1/0000056.pdf

Publication details

Download	, http://www.sciencedirect.com/science/article/B6WG1-45PMRRP-9F/2/6495c44e2463516f1fdd598aec704b6a http://hdl.handle.net/2027.42/31157 http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7713491&dopt=citation http://dx.doi.org/10.1006/geno.1994.1647
Publisher	Elsevier
Contributors	Department of Human Genetics, University of Michigan School of Medicine, and University of Michigan Human Genome Center, Ann Arbor, Michigan 48109, USA., Department of Human Genetics, University of Michigan School of Medicine, and University of Michigan Human Genome Center, Ann Arbor, Michigan 48109, USA., Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA; National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA., Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA., Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA., Department of Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Repository	University of Michigan (United States)
Keywords	Molecular, Cellular and Developmental Biology, Genetics, Biological Chemistry, Science, Health Sciences
Language	English