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Chromosomal aberrations in mouse lymphocytes exposed in vitro and in vivo to benzidine and 5 related aromatic amines (1994)

Abstract

Mouse lymphocytes were exposed in vitro for 2 h or in vivo for 24 h to benzidine and related aromatic amines to test for chromosome aberrations (CA) and mitotic indices. Uninduced mouse S9 was used to activate the amines for the in vitro tests to be consistent with the in vivo tests. Contrary to a previous report, no difference could be established in the genotoxicity of benzidine following activation with uninduced S9 compared to induced S9. There were concentration related increases in CA for benzidine and all the amines in vitro except for 4,4'-diaminostilbene which exhibited the greatest cellular toxicity towards cultured lymphocytes. Benzidine and its derivatives showed significant increases in CA in vivo compared to its negative control. The CA values for 4-aminostilbene were significantly higher than the other amines in both in vivo and in vitro studies. These genotoxicity results for 4-aminostilbene are consistent with our previous report of the pronounced CA effects in murine bone-marrow cells but would not be predicted from Salmonella mutagenicity tests.. Peer Reviewed. http://deepblue.lib.umich.edu/bitstream/2027.42/31873/1/0000823.pdf

Publication details

Download	, http://www.sciencedirect.com/science/article/B73FB-477XHSX-5K/2/b30c6cb491d20e520d6d2850d1d2d99a http://hdl.handle.net/2027.42/31873 http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7506388&dopt=citation
Publisher	Elsevier
Contributors	Department of Human Genetics, Medical School, University of Michigan, Ann Arbor, MI 48109-1065, USA, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA, Department of Human Genetics, Medical School, University of Michigan, Ann Arbor, MI 48109-1065, USA, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA
Repository	University of Michigan (United States)
Keywords	Molecular, Cellular and Developmental Biology, Genetics, Biological Chemistry, Science, Health Sciences
Language	English

Cited publications (3)

Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides (1993)

Chromosomal radiosensitivity and karyotype in mice using cultured peripheral blood lymphocytes, and comparison with this system in man (1977)

Boer, P., De,
Buul, P.P.W., Van,
Beek, R., Van,
Hoeven, F.A., Van Der,
Natarajan, A.T.

ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives (1993)