| Cytotoxic T lymphocytes directed against HLA-Bw35-linked target determinants show differences in sensitivity towards antibiotics during sensitization period. (1982) | |||||||||
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| Cytotoxic Lymphocytes Directed Against HLA linked Target Determinants Show Differences Sensitivity toward Antibiotics during Sensitization Period Satoshi Horai Eis Goulmy and Jon van Rood ABSTRACT Recently demonstrated that the outcome human CML was mfluenced the presence anttbiotics the culture medium earher itudies hadfound that cytotoxic lymphocytes could recognize HLA linked target determinants These called and determinants showed Mendehan segregation descnbe this article difference between the and cytotoxic cells thcir sensitivity touatd antibiotus The lysii against the cytotoxic determmant ivas not mfluenced either the presence the absence antibiotics during the sensitization period whereas the lysis against the cytotoxic determmant was drastically dimimshed when the tffector cells wire cultured the absence antibiotics during the sensitization period ABBREVIATIONS CML cell mediated lympholysis CTL cytotoxic lymphocyte INTRODUCTION MLC PHA mixcd lymphocyte culture phytohemagglutinm Antibiotics such penicillm and streptomycin are widely used tissue culture media prevent bactenal infection This also the case human cell typing techniques such MLC and CML Recently demonstrated that the outcome human CML test was mfluenced the presence antibiotics the culture medium Allogenic CTLs cultured the presence antibiotics during the induction phase showed significantly stronger lysis against the specific target cells companson CTLs cultured the absence antibiotics Furthermore some ca | |||||||||
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