A. Aiuti

Tyrosine phosphorylation pathway is involved in interferon-gamma (IFN-gamma) production; effect of sodium ortho vanadate.

Giovannetti, A, Aiuti, A, Pizzoli, P M, Pierdominici, M, Agostini, E, Oliva, A, ...

The molecular mechanisms regulating IFN-gamma production have yet to be well characterized. We describe here how treatment of activated cultures of peripheral blood mononuclear cells (PBMC) with the...

Biased T-cell receptor repertoires in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)

PIERDOMINICI, M, MAZZETTA, F, CAPRINI, E, MARZIALI, M, DIGILIO, M C, MARINO, B, ...

Chromosome 22q11.2 deletion (del22q11.2) syndrome (DiGeorge syndrome/velocardiofacial syndrome) is a common syndrome typically consisting of congenital heart disease, hypoparathyroidism,...

Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles

GUAZZI, V, AIUTI, F, MEZZAROMA, I, MAZZETTA, F, ANDOLFI, G, Mortellaro, A, ...

Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by repeated infections and hypogammaglobulinaemia. Additionally, T-cell abnormalities including lymphopenia,...

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

Aiuti, A., Webb, I.J., Bleul, C., Springer, T., Gutierrez-Ramos, J.C.

Hematopoietic progenitor cells migrate in vitro and in vivo towards a gradient of the chemotactic factor stromal cell-derived factor-1 (SDF-1) produced by stromal cells. This is the first...