Acute Granulomatous Response Produced in Mice by Trehalose-6,6-Dimycolate
Trehalose-6,6-dimycolate, a toxic lipid derived from tubercle bacilli, injected intravenously into mice in 10% emulsions of Bayol F caused a three- to fourfold increase in the weights of lungs...
Granuloma Formation Induced in Mice by Chemically Defined Mycobacterial Fractions
Bekierkunst, A., Levij, I. S., Yarkoni, E., Vilkas, E., Adam, A., Lederer, E.
Amounts of trehalose-6,6-dimycolate as small as 1 to 5 μg can, after intravenous injection, induce in the lungs of mice formation of tubercles in which the cellular composition is indistinguishable...
Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium.
Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose...
Yarkoni, E., Wang, L., Bekierkunst, A.
Growth of Ehrlich ascites tumor cells in mice pretreated with cord factor was compared to growth of the tumor cells after pretreatment with Calmette-Guérin bacilli. Growth of Ehrlich ascites cells...
Mice pretreated intraperitoneally with trehalose-6,6'-dimycolate (cord factor) were protected against an intraperitoneal challenge with Salmonella typhi strain Ty2 or Salmonella typhimurium strain SR...
Bekierkunst, A., Levij, I. S., Yarkoni, E., Vilkas, E., Lederer, E.
Ten micrograms of trehalose-6, 6′-dimycolate (cord factor), injected into the footpad of mice, induced histological changes similar to those following injection of living BCG bacilli. Both...
Immune Response to Sheep Red Blood Cells in Mice Pretreated with Mycobacterial Fractions
Bekierkunst, A., Yarkoni, E., Flechner, I., Morecki, S., Vilkas, E., Lederer, E.
Ten micrograms of trehalose-6,6′ -dimycolate (cord factor) injected into the footpads of mice increased the antibody response to sheep red blood cells (SRBC) subsequently injected into the same...
Stimulation of lymphocyte proliferation by killed mycobacteria and other bacterial species.
Killed mycobacteria and some mycobacterial fractions induced spleen cells from normal C3H mice to incorporate tritiated thymidine to a relatively high degree. Thymocytes under the same conditions...
Stimulation of macrophages by cord factor and by heat-killed and living BCG.
Yarkoni, E, Wang, L, Bekierkunst, A
Trehalose-6,6'-dimycolate (cord factor; CF) injected into the peritoneal cavity of mice induced stimulation of the peritoneal macrophages, evidenced both by increased activity of the lysosomal...
Granulomatous Hypersensitivity to Trehalose-6,6′-Dimycolate (Cord Factor) in Mice Infected with BCG
Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a subsequent challenge with the same substance. Mice infected with BCG bacilli...
Bekierkunst, A., Wang, L., Toubiana, R., Lederer, E.
Delipidated and deproteinized cell walls from Mycobacterium tuberculosis H37Ra suspended in 1.25% mineral oil emulsion cured established tumors in the skin and metastases in draining lymph nodes of...
Acute Granulomatous Response Produced in Mice by Trehalose-6,6-Dimycolate
Trehalose-6,6-dimycolate, a toxic lipid derived from tubercle bacilli, injected intravenously into mice in 10% emulsions of Bayol F caused a three- to fourfold increase in the weights of lungs...
Granuloma Formation Induced in Mice by Chemically Defined Mycobacterial Fractions
Bekierkunst, A., Levij, I. S., Yarkoni, E., Vilkas, E., Adam, A., Lederer, E.
Amounts of trehalose-6,6-dimycolate as small as 1 to 5 μg can, after intravenous injection, induce in the lungs of mice formation of tubercles in which the cellular composition is indistinguishable...
Immunotherapy of guinea pig line 10 hepatoma with nonliving BCG cells in aqueous medium.
Killed BCG cells suspended in 1.5% carboxymethylcellulose cured guinea pigs with established line 10 tumors in a high percentage of cases. The bacterial preparation of BCG in carboxymethylcellulose...
Yarkoni, E., Wang, L., Bekierkunst, A.
Growth of Ehrlich ascites tumor cells in mice pretreated with cord factor was compared to growth of the tumor cells after pretreatment with Calmette-Guérin bacilli. Growth of Ehrlich ascites cells...
Mice pretreated intraperitoneally with trehalose-6,6'-dimycolate (cord factor) were protected against an intraperitoneal challenge with Salmonella typhi strain Ty2 or Salmonella typhimurium strain SR...
Bekierkunst, A., Levij, I. S., Yarkoni, E., Vilkas, E., Lederer, E.
Ten micrograms of trehalose-6, 6′-dimycolate (cord factor), injected into the footpad of mice, induced histological changes similar to those following injection of living BCG bacilli. Both...
Immune Response to Sheep Red Blood Cells in Mice Pretreated with Mycobacterial Fractions
Bekierkunst, A., Yarkoni, E., Flechner, I., Morecki, S., Vilkas, E., Lederer, E.
Ten micrograms of trehalose-6,6′ -dimycolate (cord factor) injected into the footpads of mice increased the antibody response to sheep red blood cells (SRBC) subsequently injected into the same...
Stimulation of lymphocyte proliferation by killed mycobacteria and other bacterial species.
Killed mycobacteria and some mycobacterial fractions induced spleen cells from normal C3H mice to incorporate tritiated thymidine to a relatively high degree. Thymocytes under the same conditions...
Stimulation of macrophages by cord factor and by heat-killed and living BCG.
Yarkoni, E, Wang, L, Bekierkunst, A
Trehalose-6,6'-dimycolate (cord factor; CF) injected into the peritoneal cavity of mice induced stimulation of the peritoneal macrophages, evidenced both by increased activity of the lysosomal...
Granulomatous Hypersensitivity to Trehalose-6,6′-Dimycolate (Cord Factor) in Mice Infected with BCG
Cord factor in the form of emulsion is unable to sensitize mice to react with a more extensive granulomatous response to a subsequent challenge with the same substance. Mice infected with BCG bacilli...
Bekierkunst, A., Wang, L., Toubiana, R., Lederer, E.
Delipidated and deproteinized cell walls from Mycobacterium tuberculosis H37Ra suspended in 1.25% mineral oil emulsion cured established tumors in the skin and metastases in draining lymph nodes of...
Brucella : Studies on the Mechanism of Non-Specific Resistance to
Sulitzeanu, D., Bekierkunst, A., Groto, Lea, Loebel, Judith
Mice vaccinated with living or killed BCG become resistant to infection with Brucella abortus, as evidenced by a lower bacterial count in the spleen and liver as compared to controls. Some of the...