Bye, A., Hoydal, M.A., Catalucci, D., Langaas, M., Kemi, O.J., Beisvag, V., ...
The relationship between inborn maximal oxygen uptake (VO2max) and skeletal muscle gene expression is unknown. Since low VO2max is a strong predictor of cardiovascular mortality, genes related to low...
Aerobic capacity-dependent differences in cardiac gene expression (2008)
Bye, A., Langaas, M., Høydal, M.A., Kemi, O.J., Heinrich, G., Koch, L.G., ...
Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between inborn aerobic capacity and cardiac gene expression we examined genome-wide gene expression...
Aerobic capacity-dependent differences in cardiac gene expression (2007)
Bye, A., Langaas, M., Hoydal, M.A., Kemi, O.J., Heinrich, G., Koch, L.G., ...
Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between inborn aerobic capacity and cardiac gene expression we examined genome-wide gene expression...
Monte Carlo Simulation, G. L. Drusano, J. P. Kleim, W. Prince, A. Bye
In order to choose a rational dose for GW 420867X, we first set a goal of therapy. We hypothesized that, for optimal antiretroviral activity, the trough free drug concentration should remain above...
Brigden, D., Bye, A., Fowle, A.S.E., Rogers, H.
Acyclovir [9-(2 hydroxyethoxymethyl)guanine] an acyclic nucleoside of guanine with potent antiviral activity against the herpes simplex virus both in vitro and topically in man was injected as a...
Salmon, J. D., Fowle, A. S. W., Bye, A.
Aqueous humour was sampled simultaneously with plasma from patients under going cataract surgery. All the patients had taken co-trimoxazole for various periods ending at various intervals before...
Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., ...
The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and...
Drusano, G. L., D’Argenio, D. Z., Symonds, W., Bilello, P. A., McDowell, J., Sadler, B., ...
The use of combinations of anti-human immunodeficiency virus (anti-HIV) agents targeted to different molecular targets will most likely result in increased viral suppression and may also delay or...
Pharmacodynamics of Abacavir in an In Vitro Hollow-Fiber Model System
Drusano, G. L., Bilello, P. A., Symonds, W. T., Stein, D. S., McDowell, J., Bye, A., ...
Abacavir is a potent new carbocyclic nucleoside analogue. We employed our hollow-fiber pharmacodynamic modeling system to examine the antiretroviral effects of different abacavir exposures, as well...
Drusano, G. L., Moore, K. H. P., Kleim, J. P., Prince, W., Bye, A.
In order to choose a rational dose for GW 420867X, we first set a goal of therapy. We hypothesized that, for optimal antiretroviral activity, the trough free drug concentration should remain above...
Novak, E, Paxton, L M, Bye, A, Patel, R, Zurenko, G E, Francom, S F
In this study, local and systemic tolerance and pharmacokinetics of trospectomycin sulfate in human beings were evaluated for the first time. Trospectomycin sulfate (U-63,366F; trospectomycin) or...
The biosynthesis of 4-hydroxycoumarin and dicoumarol by Aspergillus fumigatus Fresenius
A strain of Aspergillus fumigatus Fresenius, isolated from spoiled hay, converts melilotic acid (o-hydroxyphenylpropionic acid) and o-coumaric acid into 4-hydroxycoumarin and dicoumarol. The sequence...
Successful treatment of experimental B virus (Herpesvirus simiae) infection with acyclovir.
Boulter, E A, Thornton, B, Bauer, D J, Bye, A
The efficacy of the new nucleoside analogue acyclovir against B virus (Herpesvirus simiae) was investigated in rabbits and Vero cells infected with 2-136 and 0.3-1.0 TCD50 of the virus respectively....
Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., ...
The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and...
Drusano, G. L., D’Argenio, D. Z., Symonds, W., Bilello, P. A., McDowell, J., Sadler, B., ...
The use of combinations of anti-human immunodeficiency virus (anti-HIV) agents targeted to different molecular targets will most likely result in increased viral suppression and may also delay or...
Pharmacodynamics of Abacavir in an In Vitro Hollow-Fiber Model System
Drusano, G. L., Bilello, P. A., Symonds, W. T., Stein, D. S., McDowell, J., Bye, A., ...
Abacavir is a potent new carbocyclic nucleoside analogue. We employed our hollow-fiber pharmacodynamic modeling system to examine the antiretroviral effects of different abacavir exposures, as well...
Drusano, G. L., Moore, K. H. P., Kleim, J. P., Prince, W., Bye, A.
In order to choose a rational dose for GW 420867X, we first set a goal of therapy. We hypothesized that, for optimal antiretroviral activity, the trough free drug concentration should remain above...
Novak, E, Paxton, L M, Bye, A, Patel, R, Zurenko, G E, Francom, S F
In this study, local and systemic tolerance and pharmacokinetics of trospectomycin sulfate in human beings were evaluated for the first time. Trospectomycin sulfate (U-63,366F; trospectomycin) or...
The biosynthesis of 4-hydroxycoumarin and dicoumarol by Aspergillus fumigatus Fresenius
A strain of Aspergillus fumigatus Fresenius, isolated from spoiled hay, converts melilotic acid (o-hydroxyphenylpropionic acid) and o-coumaric acid into 4-hydroxycoumarin and dicoumarol. The sequence...
Successful treatment of experimental B virus (Herpesvirus simiae) infection with acyclovir.
Boulter, E A, Thornton, B, Bauer, D J, Bye, A
The efficacy of the new nucleoside analogue acyclovir against B virus (Herpesvirus simiae) was investigated in rabbits and Vero cells infected with 2-136 and 0.3-1.0 TCD50 of the virus respectively....
Ashforth, E I, Palmer, J L, Bye, A, Bedding, A
The pharmacokinetics of the 5-HT3 receptor antagonist ondansetron following an 8 mg i.v. dose were investigated in 12 subjects previously phenotyped with debrisoquine. Six subjects were poor...
Nichols, D J, Bye, A, Novak, E
The pharmacokinetics of trospectomycin (75-1000 mg free base equivalents) were studied in 128 healthy males (eight per dose group), after a 20 min intravenous (i.v.) infusion and intramuscular (i.m.)...
Chee, K Y, Lee, D, Byron, D, Naidoo, D, Bye, A
We have developed a method of monitoring plasma concentrations of antiepileptic drugs which uses salivary samples, and is suitable for home monitoring in children. To validate the method, paired...
Human gastrointestinal absorption of acyclovir from tablet duodenal infusion and sipped solution.
Lewis, L D, Fowle, A S, Bittiner, S B, Bye, A, Isaacs, P E
On two occasions at least 1 week apart, nine healthy male volunteers were administered in random order either 2 X 200 mg (1.8 mmol) acyclovir tablets or 400 mg of acyclovir in 500 ml of 5% dextrose...
Effect of a single oral dose of aspirin on the platelet aggregation response to arachidonic acid.
1 The platelet aggregation response to arachidonic acid ex vivo was measured in six volunteers daily before and for 10 days after a single oral dose of 600 mg aspirin. 2 Arachidonic acid induced...
Synergy of trimethoprim and sulphonamides (T)
Barnett, Margaret, Bushby, S. R. M., Bye, A., Fox, A. F. J., Spilsbury, J. F., Udall, V.
Pharmacokinetics of intravenous fluticasone propionate in healthy subjects
MACKIE, A. E., VENTRESCA, G. P., FULLER, R. W., BYE, A.
1Fluticasone propionate (FP) is a potent glucocorticoid used in the treatment of asthma. Prior to reporting the pharmacokinetics following the inhaled and oral routes, the pharmacokinetics need to be...
Aerobic capacity-dependent differences in cardiac gene expression
Bye, A., Langaas, M., Høydal, M.A., Kemi, O.J., Heinrich, G., Koch, L.G., ...
Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between inborn aerobic capacity and cardiac gene expression we examined genome-wide gene expression...