Agrawal, A., Lynskey, M. T., Bucholz, K. K., Martin, N. G., Madden, P. A., Heath, A. C.
BACKGROUND: The use of cannabis and other illicit drugs (OIDs) and their co-morbid misuse are frequently reported in the literature. Correlated vulnerabilities and causal or gateway influences have...
Birley, A. J., James, M. R., Dickson, P. A., Montgomery, G. W., Heath, A. C., Whitfield, J. B., ...
Seven alcohol metabolising enzymes are encoded by the human alcohol dehydrogenase (ADH) gene cluster on chromosome 4q22-23. One of these genes, ADH7, is uniquely expressed in the stomach mucosa and...
Intergenerational transmission of childhood conduct problems: a Children of Twins Study (2007)
D'Onofrio, B. M., Slutske, W. S., Turkheimer, E., Emery, R. E., Harden, K. P., Heath, A. C., ...
CONTEXT: The familial nature of childhood conduct problems has been well documented, but few genetically informed studies have explicitly explored the processes through which parental conduct...
Grant, J. D., Heath, A. C., Bucholz, K. K., Madden, P. A., Agrawal, A., Statham, D. J., ...
BACKGROUND: Alcohol dependence (AD) is among the most common psychiatric disorders, and impacts the health and well-being of problem drinkers, their family members, and society as a whole. Although...
Marital conflict and conduct problems in Children of Twins (2007)
Harden, K. P., Turkheimer, E., Emery, R. E., D'Onofrio, B. M., Slutske, W. S., Heath, A. C., ...
The Children-of-Twins design was used to test whether associations between marital conflict frequency and conduct problems can be replicated within the children of discordant twin pairs. A sample of...
The Genetics of Voting: an Australian Twin Study (2007)
Hatemi, P. K., Medland, S. E., Morley, K. I., Heath, A. C., Martin, N. G.
Previously we and others have shown evidence for genetic influences on political attitudes and sociodemographic indicators (Martin 1987; Posner et al. 1996; Truett et al. 1992; Eaves et al. 1999)....
Cohort Trends in Prevalence and Spousal Concordance for Smoking (2007)
Kuo, P. H., Wood, P., Morley, K. I., Madden, P., Martin, N. G., Heath, A. C.
Evaluation of the pattern of smoking prevalence over time could provide insight for disease prevention and tobacco control policy. Examination of assortative mating is important in assessing the...
Loukola, A., Broms, U., Maunu, H., Widen, E., Heikkila, K., Siivola, M., ...
The significant worldwide health burden introduced by tobacco smoking highlights the importance of studying the genetic determinants of smoking behavior and the key factor sustaining compulsive...
"No thanks, it keeps me awake". The genetics of coffee-attributed sleep disturbance (2007)
Luciano, M., Ghu, Z., Kirk, K.M., Gordon, S.D., Heath, A.C., Montgomery, G.W., ...
Lynskey, M. T., Grant, J. D., Li, L., Nelson, E. C., Bucholz, K. K., Madden, P. A., ...
BACKGROUND: This paper explores the magnitude of--and extent of overlap between--additive genetic, shared environmental and non-shared environmental influences on lifetime stimulant use and on...
Morley, K. I., Lynskey, M. T., Madden, P. A., Treloar, S. A., Heath, A. C., Martin, N. G.
BACKGROUND: We investigated the genetic and environmental contributions to covariation between smoking age-at-onset, cigarette consumption and smoking persistence. METHOD: Multivariate biometrical...
Saccone, S. F., Pergadia, M. L., Loukola, A., Broms, U., Montgomery, G. W., Wang, J. C., ...
We conducted a genomewide linkage screen of a simple heavy-smoking quantitative trait, the maximum number of cigarettes smoked in a 24-h period, using two independent samples: 289 Australian and 155...
Age at first sexual intercourse and teenage pregnancy in Australian female twins (2007)
Waldron, M., Heath, A. C., Turkheimer, E., Emery, R., Bucholz, K. K., Madden, P. A., ...
Girls who report first sexual intercourse during their early teen years have much higher rates of teenage pregnancy and childbearing than girls who delay sexual onset until older adolescence. In this...
Waldron, M., Heath, A. C., Turkheimer, E. N., Emery, R. E., Nelson, E., Bucholz, K. K., ...
We examine interactive effects of childhood sexual abuse (CSA) on heritable variation in age at first consensual sexual intercourse in a young cohort of 3,350 female and 2,724 male Australian twins....
Evidence of genetic effects on blood lead concentration (2007)
Whitfield, J. B., Dy, V., McQuilty, R., Zhu, G., Montgomery, G. W., Ferreira, M. A., ...
BACKGROUND: Lead is an environmental pollutant that causes acute and chronic toxicity. Surveys have related mean blood lead concentrations to exogenous sources, including industrial activity, use of...
HLA and genome wide allele sharing in dizygotic twins. (2006)
Montgomery, G.W., Zhu, G., Hottenga, J.J., Duffy, D.L., Heath, A.C., Boomsma, D.I., ...
Duration of cannabis use - a novel phenotype? (2006)
Lynskey, M. T., Grant, J. D., Nelson, E. C., Bucholz, K. K., Madden, P. A. F., Statham, D. J., ...
Lynskey, M. T., Agrawal, A., Bucholz, K. K., Nelson, E. C., Madden, P. A. F., Todorov, A. A., ...
This article applies methods of latent class analysis (LCA) to data on lifetime illicit drug use in order to determine whether qualitatively distinct classes of illicit drug users can be identified....
Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study (2006)
Nelson, E. C., Heath, A. C., Lynskey, M. T., Bucholz, K. K., Madden, P. A. F., Statham, D. J., ...
HLA and genomewide allele sharing in dizygotic twins (2006)
Montgomery, G. W., Zhu, G., Hottenga, J. J., Duffy, D. L., Heath, A. C., Boomsma, D. I., ...
Gametic selection during fertilization or the effects of specific genotypes on the viability of embryos may cause a skewed transmission of chromosomes to surviving offspring. A recent analysis of...
Genetic and cultural transmission of smoking initiation: An extended twin kinship model (2006)
Maes, H. H., Neale, M. C., Kendler, K. S., Martin, N. G., Heath, A. C., Eaves, L. J.
Heritability and nineteen-year stability of long and short EPQ-R Neuroticism scales (2005)
Birley, A.J., Gillespie, N.A., Heath, A.C., Sullivan, P.F., Boomsma, D.I., Martin, N.G.
Genomewide significant linkage to migrainous headache on chromosome 5q21 (2005)
Nyholt, D. R., Morley, K. I., Ferreira, M. A. R., Medland, S. E., Boomsma, D. I., Heath, A. C., ...
Familial typical migraine is a common, complex disorder that shows strong familial aggregation. Using latent-class analysis (LCA), we identified subgroups of people with migraine/severe headache in a...
Kirk, K. M., Blomberg, S. P., Duffy, D. L., Heath, A. C., Owens, I. P., Martin, N. G.
Whether contemporary human populations are still evolving as a result of natural selection has been hotly debated. For natural selection to cause evolutionary change in a trait, variation in the...
An integrative approach for studying the etiology of alcoholism and other addictions (2001)
Jacob, T., Sher, K. J., Bucholz, K. K., True, W. T., Sirevaag, E. J., Rohrbaugh, J. W., ...
Studies of alcoholism etiology often focus on genetic or psy-chosocial approaches, but not both. Greater understanding of the etiology of alcohol, tobacco and other addictions will come from...
Whitfield, J. B., Zhu, G., Heath, A. C., Martin, N. G., Powell, L. W.
Background: Alcohol increases body iron stores. Alcohol and iron may increase oxidative stress and the risk of alcohol-related liver disease. The relationship between low or safe levels of alcohol...
Wade, T., Martin, N. G., Tiggemann, M., Abraham, S., Treloar, S. A., Heath, A. C.
The aim of this paper is to examine the sources and structure of covariation between disordered eating, neuroticism, parental care and protection, self-esteem and emotional reliance on other people....
Wade, T., Martin, N. G., Neale, M. C., Tiggemann, M., Treloar, S. A., Bucholz, K. K., ...
Background. The study explored the genetic and environmental risk factors for both the behaviours and attitudes characteristic of disordered eating. Methods. In three waves of data collection,...
Somatic distress as a distinct psychological dimension (1999)
Gillespie, N., Kirk, K. M., Heath, A. C., Martin, N. G., Hickie, I.
Background: Somatoform disorders such as neurasthenia and chronic fatigue are characterized by a combination of prolonged fatigue and disabling neuropsychological and neuromuscular symptoms. However,...
Testing hypotheses about direction of causation using cross-sectional family data (1993)
Hewitt, J. K., Kendler, Kenneth S., Heath, A. C., Kessler, Ronald C, Neale, Michael C., Eaves, Lindon J.
We review the conditions under which cross-sectional family data (e.g., data on twin pairs or adoptees and their adoptive and biological relatives) are informative about direction of causation. When...
Silberg, J. L., Heath, A. C., Kessler, R., Neale, Michael C., Meyer, J. M., Eaves, Lindon J., ...
To determine the etiology of self-reported depressive symptoms and their co-occurrence in the general population, multivariate genetic models were fitted to the responses of 771 female twin pairs...
Human quantitative genetics [microform] : some issues and applications / (1983)
BLDSC reference no.: D49868/84.
Transmission of social attitudes.
Martin, N G, Eaves, L J, Heath, A C, Jardine, R, Feingold, L M, Eysenck, H J
Data gathered in Australia and England on the social attitudes of spouses and twins are largely consistent with a genetic model for family resemblance in social attitudes. There is substantial...
Genetic and environmental contributions to healthcare need and utilization: a twin analysis.
True, W R, Romeis, J C, Heath, A C, Flick, L H, Shaw, L, Eisen, S A, ...
OBJECTIVE: An exploratory study to examine the genetic and environmental influences on healthcare-seeking behavior for four health conditions (high blood pressure, mental health problems, joint...
Heritability of self-reported health.
Romeis, J C, Scherrer, J F, Xian, H, Eisen, S A, Bucholz, K, Heath, A C, ...
OBJECTIVE: To explore the contribution of genes and environmental factors to variation in a common measure (i.e., a five-point--excellent, very good, good, fair, and poor--Likert scale) of...
Whitfield, J. B., Cullen, L. M., Jazwinska, E. C., Powell, L. W., Heath, A. C., Zhu, G., ...
The aim of this study was to assess and to compare the role of HFE polymorphisms and other genetic factors in variation in iron stores. Blood samples were obtained from 3,375 adult male and female...
Evidence for Polygenic Epistatic Interactions in Man?
Heath, A. C., Martin, N. G., Eaves, L. J., Loesch, D.
Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins,...
Transmission of social attitudes.
Martin, N G, Eaves, L J, Heath, A C, Jardine, R, Feingold, L M, Eysenck, H J
Data gathered in Australia and England on the social attitudes of spouses and twins are largely consistent with a genetic model for family resemblance in social attitudes. There is substantial...
Genetic and environmental contributions to healthcare need and utilization: a twin analysis.
True, W R, Romeis, J C, Heath, A C, Flick, L H, Shaw, L, Eisen, S A, ...
OBJECTIVE: An exploratory study to examine the genetic and environmental influences on healthcare-seeking behavior for four health conditions (high blood pressure, mental health problems, joint...
Heritability of self-reported health.
Romeis, J C, Scherrer, J F, Xian, H, Eisen, S A, Bucholz, K, Heath, A C, ...
OBJECTIVE: To explore the contribution of genes and environmental factors to variation in a common measure (i.e., a five-point--excellent, very good, good, fair, and poor--Likert scale) of...
Evidence for Polygenic Epistatic Interactions in Man?
Heath, A. C., Martin, N. G., Eaves, L. J., Loesch, D.
Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins,...
Whitfield, J. B., Cullen, L. M., Jazwinska, E. C., Powell, L. W., Heath, A. C., Zhu, G., ...
The aim of this study was to assess and to compare the role of HFE polymorphisms and other genetic factors in variation in iron stores. Blood samples were obtained from 3,375 adult male and female...