Lyme disease: a growing threat to urban populations.
Lyme disease or Lyme borreliosis, which is caused by three groups of the spirochete Borrelia burgdorferi, is transmitted in North America, Europe, and Asia by ticks of the Ixodes ricinus complex. The...
Human Antibody Responses to VlsE Antigenic Variation Protein of Borrelia burgdorferi
Lawrenz, M. B., Hardham, J. M., Owens, R. T., Nowakowski, J., Steere, A. C., Wormser, G. P., ...
VlsE is a 35-kDa surface-exposed lipoprotein of Borrelia burgdorferi that was shown previously to undergo antigenic variation through segmental recombination of silent vls cassettes with vlsE during...
Kalish, R A, Leong, J M, Steere, A C
The immunoglobulin G (IgG) antibody response to outer surface protein A (OspA) of Borrelia burgdorferi has been reported to occur late in the course of Lyme disease. To learn when reactivity to...
Kamradt, T, Lengl-Janssen, B, Strauss, A F, Bansal, G, Steere, A C
In an earlier study, we found that T-cell lines (TCL) from five patients with treatment-resistant Lyme arthritis preferentially recognized Borrelia burgdorferi outer surface protein A (OspA), but TCL...
Experimental Lyme disease in rabbits: spirochetes found in erythema migrans and blood.
Kornblatt, A N, Steere, A C, Brownstein, D G
In attempts to produce experimental Lyme disease, 33 rabbits were inoculated with Lyme spirochetes by tick feeding or from tick organ homogenates or cultures. Two rabbits developed erythema chronicum...
Newly recognized Leptospira species ("Leptospira inadai" serovar lyme) isolated from human skin.
Schmid, G P, Steere, A C, Kornblatt, A N, Kaufmann, A F, Moss, C W, Johnson, R C, ...
Leptospira strain 10, which represents a new Leptospira species, was isolated from a skin biopsy of a patient with Lyme disease. Although pathogenic for laboratory animals, the organism was not...
DNA characterization of the spirochete that causes Lyme disease.
Schmid, G P, Steigerwalt, A G, Johnson, S E, Barbour, A G, Steere, A C, Robinson, I M, ...
Lyme disease, a tick-borne disease long recognized in Europe but only recently recognized in the United States, was shown in 1982-1983 to be caused by a spirochete, the Lyme disease spirochete....
Kalish, R A, Leong, J M, Steere, A C
Chronic Lyme arthritis that is unresponsive to antibiotic therapy is associated with an increased frequency of the HLA-DR4 specificity. To determine whether the immune response to a particular...
Fung, B P, McHugh, G L, Leong, J M, Steere, A C
We determined the humoral immune response to outer surface protein C (OspC) of Borrelia burgdorferi in patients with early or late manifestations of Lyme disease and investigated the use of this...
Miller, L C, Isa, S, Vannier, E, Georgilis, K, Steere, A C, Dinarello, C A
Lyme arthritis is one of the few forms of chronic arthritis in which the cause is known with certainty. Because cytokines are thought to contribute to the pathogenesis of chronic arthritis, we...
Craft, J E, Fischer, D K, Shimamoto, G T, Steere, A C
Using immunoblots, we identified proteins of Borrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were...
Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete.
Barbour, A G, Burgdorfer, W, Grunwaldt, E, Steere, A C
Lyme disease is an inflammatory disorder of skin, joints, nervous system, and heart. The disease is associated with a preceding tick bite and is ameliorated by penicillin treatment. A spirochete...
Lyme disease: a growing threat to urban populations.
Lyme disease or Lyme borreliosis, which is caused by three groups of the spirochete Borrelia burgdorferi, is transmitted in North America, Europe, and Asia by ticks of the Ixodes ricinus complex. The...
Human Antibody Responses to VlsE Antigenic Variation Protein of Borrelia burgdorferi
Lawrenz, M. B., Hardham, J. M., Owens, R. T., Nowakowski, J., Steere, A. C., Wormser, G. P., ...
VlsE is a 35-kDa surface-exposed lipoprotein of Borrelia burgdorferi that was shown previously to undergo antigenic variation through segmental recombination of silent vls cassettes with vlsE during...
Kalish, R A, Leong, J M, Steere, A C
The immunoglobulin G (IgG) antibody response to outer surface protein A (OspA) of Borrelia burgdorferi has been reported to occur late in the course of Lyme disease. To learn when reactivity to...
Kamradt, T, Lengl-Janssen, B, Strauss, A F, Bansal, G, Steere, A C
In an earlier study, we found that T-cell lines (TCL) from five patients with treatment-resistant Lyme arthritis preferentially recognized Borrelia burgdorferi outer surface protein A (OspA), but TCL...
Experimental Lyme disease in rabbits: spirochetes found in erythema migrans and blood.
Kornblatt, A N, Steere, A C, Brownstein, D G
In attempts to produce experimental Lyme disease, 33 rabbits were inoculated with Lyme spirochetes by tick feeding or from tick organ homogenates or cultures. Two rabbits developed erythema chronicum...
Newly recognized Leptospira species ("Leptospira inadai" serovar lyme) isolated from human skin.
Schmid, G P, Steere, A C, Kornblatt, A N, Kaufmann, A F, Moss, C W, Johnson, R C, ...
Leptospira strain 10, which represents a new Leptospira species, was isolated from a skin biopsy of a patient with Lyme disease. Although pathogenic for laboratory animals, the organism was not...
DNA characterization of the spirochete that causes Lyme disease.
Schmid, G P, Steigerwalt, A G, Johnson, S E, Barbour, A G, Steere, A C, Robinson, I M, ...
Lyme disease, a tick-borne disease long recognized in Europe but only recently recognized in the United States, was shown in 1982-1983 to be caused by a spirochete, the Lyme disease spirochete....
Kalish, R A, Leong, J M, Steere, A C
Chronic Lyme arthritis that is unresponsive to antibiotic therapy is associated with an increased frequency of the HLA-DR4 specificity. To determine whether the immune response to a particular...
Fung, B P, McHugh, G L, Leong, J M, Steere, A C
We determined the humoral immune response to outer surface protein C (OspC) of Borrelia burgdorferi in patients with early or late manifestations of Lyme disease and investigated the use of this...
Miller, L C, Isa, S, Vannier, E, Georgilis, K, Steere, A C, Dinarello, C A
Lyme arthritis is one of the few forms of chronic arthritis in which the cause is known with certainty. Because cytokines are thought to contribute to the pathogenesis of chronic arthritis, we...
Craft, J E, Fischer, D K, Shimamoto, G T, Steere, A C
Using immunoblots, we identified proteins of Borrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were...
Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete.
Barbour, A G, Burgdorfer, W, Grunwaldt, E, Steere, A C
Lyme disease is an inflammatory disorder of skin, joints, nervous system, and heart. The disease is associated with a preceding tick bite and is ameliorated by penicillin treatment. A spirochete...
Expression of public idiotypes in patients with Lyme arthritis.
Axford, J S, Watts, R A, Long, A A, Isenberg, D A, Steere, A C
OBJECTIVE: Joints are often affected in Lyme disease and in some instances this may be due to immune autoreactivity. To characterise further the immune response in this disease investigations were...
Duijvestijn, A. M., Horst, E., Pals, S. T., Rouse, B. N., Steere, A. C., Picker, L. J., ...
Lymphocyte traffic into lymph nodes and into mucosa-associated lymphoid tissues is regulated by specialized postcapillary high endothelial venules (HEVs). The authors have produced a rat monoclonal...
Lyme arthritis. Spirochetes found in synovial microangiopathic lesions.
Johnston, Y. E., Duray, P. H., Steere, A. C., Kashgarian, M., Buza, J., Malawista, S. E., ...
In 17 patients with Lyme disease, synovial specimens, obtained by synovectomy or needle biopsy, showed nonspecific villous hypertrophy, synovial cell hyperplasia, prominent microvasculature,...