A. Chenna

An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5′ cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site

Hang, B., Chenna, A., Fraenkel-Conrat, H., Singer, B.

The major human apurinic/apyrimidinic (AP) endonuclease (class II) is known to cleave DNA 5′ adjacent to an AP site, which is probably the most common DNA damage produced hydrolytically or by...

The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase.

Chenna, A, Hang, B, Rydberg, B, Kim, E, Pongracz, K, Bodell, W J, ...

Benzene is a ubitiquous human environment mental carcinogen. One of the major metabolites is hydroquinone, which is oxidized in vivo to give p-benzoquinone (p-BQ). Both metabolites are toxic to human...

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon...

An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5′ cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site

Hang, B., Chenna, A., Fraenkel-Conrat, H., Singer, B.

The major human apurinic/apyrimidinic (AP) endonuclease (class II) is known to cleave DNA 5′ adjacent to an AP site, which is probably the most common DNA damage produced hydrolytically or by...

The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase.

Chenna, A, Hang, B, Rydberg, B, Kim, E, Pongracz, K, Bodell, W J, ...

Benzene is a ubitiquous human environment mental carcinogen. One of the major metabolites is hydroquinone, which is oxidized in vivo to give p-benzoquinone (p-BQ). Both metabolites are toxic to human...

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon...