Hughes, R K, Doyle, W A, Chovnick, A, Whittle, J R, Burke, J F, Bray, R C
The usefulness in structure/function studies of molybdenum-containing hydroxylases in work with rosy mutant strains of Drosophila melanogaster has been investigated. At least 23 such strains are...
This report describes cytological, genetic and biochemical studies designed to characterize two γ-radiation induced, apparent "underproducer" variants of the rosy locus (ry:3-52.0), ryps1149 and...
Rushlow, C. A., Bender, W., Chovnick, A.
Experiments are described that extend the characterization of position effect variants of the rosy locus and test possible mechanisms of heterochromatic position effect.—Rosy position effect...
Clark, S. H., McCarron, M., Love, C., Chovnick, A.
DNA extracts of several rosy-mutation-bearing strains were associated with large insertions and deletions in a defined region of the molecular map believed to include the rosy locus DNA. Large-scale,...
Clark, S. H., Hilliker, A. J., Chovnick, A.
This report presents the results of a recombination experiment designed to question the existence of special sites for the initiation or termination of a recombination heteroduplex within the region...
Hybrid Dysgenesis in Drosophila Simulans Lines Transformed with Autonomous P Elements
Daniels, S. B., Chovnick, A., Kidwell, M. G.
The molecular and phenotypic analysis of several previously described P element-transformed lines of Drosophila simulans was extended in order to determine whether they had the potential to produce a...
Molecular Analysis of Recombination Events in Drosophila
Curtis, D., Clark, S. H., Chovnick, A., Bender, W.
The locations of crossover junctions and gene conversion tracts, isolated in the rosy gene of Drosophila melanogaster, were determined using DNA sequencing and denaturing gradient gel...
Xanthine Dehydrogenase Is Transported to the Drosophila Eye
Reaume, A. G., Clark, S. H., Chovnick, A.
The rosy (ry) locus in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase. Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a...
The Relationship between P Elements and Male Recombination in Drosophila Melanogaster
Duttaroy, A., McCarron, M., Sitaraman, K., Doughty, G., Chovnick, A.
P element dysgenesis associated male recombination in Drosophila was examined with a selective system focused upon 5% of the standard female genetic map divided into eight recombination segments. We...
Evidence for Horizontal Transmission of the P Transposable Element between Drosophila Species
Daniels, S. B., Peterson, K. R., Strausbaugh, L. D., Kidwell, M. G., Chovnick, A.
Several studies have suggested that P elements have rapidly spread through natural populations of Drosophila melanogaster within the last four decades. This observation, together with the observation...
Cloning and Characterization of the Scalloped Region of Drosophila Melanogaster
Campbell, S. D., Duttaroy, A., Katzen, A. L., Chovnick, A.
Viable mutants of the scalloped gene (sd) of Drosophila melanogaster exhibit defects that can include gapping of the wing margin and ectopic bristle formation on the wing. Lethal sd alleles...
Dutton-Jr, F. L., Chovnick, A.
l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional...
Hilliker, A. J., Clark, S. H., Chovnick, A.
The effect of simple DNA sequence polymorphisms on intragenic recombination in the rosy locus of Drosophila melanogaster was assayed. Two crosses were performed involving nearly identical molecular...
The Rosy Locus in Drosophila Melanogaster: Xanthine Dehydrogenase and Eye Pigments
Reaume, A. G., Knecht, D. A., Chovnick, A.
The rosy gene in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase (XDH). Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a...
The gap-repair model proposes that P elements move via a conservative, ``cut-and-paste'' mechanism followed by double-strand gap repair, using either the sister chromatid or homolog as the repair...
McCarron, M., Duttaroy, A., Doughty, G., Chovnick, A.
P element dysgenesis-associated male recombination in Drosophila was examined with a selective system focused upon a section of the third chromosome divided into eight recombination segments. Tests...
Meiotic Gene Conversion Tract Length Distribution within the Rosy Locus of Drosophila Melanogaster
Hilliker, A. J., Harauz, G., Reaume, A. G., Gray, M., Clark, S. H., Chovnick, A.
Employing extensive co-conversion data for selected and unselected sites of known molecular location in the rosy locus of Drosophila melanogaster, we determine the parameters of meiotic gene...
Chovnick, A., Gelbart, W., McCarron, M., Osmond, B., Candido, E. P. M., Baillie, D. L.
From a collection of electrophoretic variants of XDH obtained from laboratory strains and natural populations, a stock was isolated that was associated with much greater than normal levels of XDH...
McCarron, M., O'Donnell, J., Chovnick, A., Bhullar, B. S., Hewitt, J., Candido, E. P. M.
The present report summarizes our recent progress in the genetic dissection of an elementary genetic unit in a higher organism, the rosy locus (ry:3–52.0) in Drosophila melanogaster. Pursuing the...
Clark, S. H., Daniels, S., Rushlow, C. A., Hilliker, A. J., Chovnick, A.
Prior reports from this laboratory have described the experimental basis for our understanding of the genetic organization of the rosy locus (ry:3-52.0) of Drosophila melanogaster, as a bipartite...
Hughes, R K, Doyle, W A, Chovnick, A, Whittle, J R, Burke, J F, Bray, R C
The usefulness in structure/function studies of molybdenum-containing hydroxylases in work with rosy mutant strains of Drosophila melanogaster has been investigated. At least 23 such strains are...
This report describes cytological, genetic and biochemical studies designed to characterize two γ-radiation induced, apparent "underproducer" variants of the rosy locus (ry:3-52.0), ryps1149 and...
Rushlow, C. A., Bender, W., Chovnick, A.
Experiments are described that extend the characterization of position effect variants of the rosy locus and test possible mechanisms of heterochromatic position effect.—Rosy position effect...
Clark, S. H., McCarron, M., Love, C., Chovnick, A.
DNA extracts of several rosy-mutation-bearing strains were associated with large insertions and deletions in a defined region of the molecular map believed to include the rosy locus DNA. Large-scale,...
Clark, S. H., Hilliker, A. J., Chovnick, A.
This report presents the results of a recombination experiment designed to question the existence of special sites for the initiation or termination of a recombination heteroduplex within the region...
Hybrid Dysgenesis in Drosophila Simulans Lines Transformed with Autonomous P Elements
Daniels, S. B., Chovnick, A., Kidwell, M. G.
The molecular and phenotypic analysis of several previously described P element-transformed lines of Drosophila simulans was extended in order to determine whether they had the potential to produce a...
Molecular Analysis of Recombination Events in Drosophila
Curtis, D., Clark, S. H., Chovnick, A., Bender, W.
The locations of crossover junctions and gene conversion tracts, isolated in the rosy gene of Drosophila melanogaster, were determined using DNA sequencing and denaturing gradient gel...
Xanthine Dehydrogenase Is Transported to the Drosophila Eye
Reaume, A. G., Clark, S. H., Chovnick, A.
The rosy (ry) locus in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase. Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a...
The Relationship between P Elements and Male Recombination in Drosophila Melanogaster
Duttaroy, A., McCarron, M., Sitaraman, K., Doughty, G., Chovnick, A.
P element dysgenesis associated male recombination in Drosophila was examined with a selective system focused upon 5% of the standard female genetic map divided into eight recombination segments. We...
Evidence for Horizontal Transmission of the P Transposable Element between Drosophila Species
Daniels, S. B., Peterson, K. R., Strausbaugh, L. D., Kidwell, M. G., Chovnick, A.
Several studies have suggested that P elements have rapidly spread through natural populations of Drosophila melanogaster within the last four decades. This observation, together with the observation...
Cloning and Characterization of the Scalloped Region of Drosophila Melanogaster
Campbell, S. D., Duttaroy, A., Katzen, A. L., Chovnick, A.
Viable mutants of the scalloped gene (sd) of Drosophila melanogaster exhibit defects that can include gapping of the wing margin and ectopic bristle formation on the wing. Lethal sd alleles...
Dutton-Jr, F. L., Chovnick, A.
l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional...
Hilliker, A. J., Clark, S. H., Chovnick, A.
The effect of simple DNA sequence polymorphisms on intragenic recombination in the rosy locus of Drosophila melanogaster was assayed. Two crosses were performed involving nearly identical molecular...
The Rosy Locus in Drosophila Melanogaster: Xanthine Dehydrogenase and Eye Pigments
Reaume, A. G., Knecht, D. A., Chovnick, A.
The rosy gene in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase (XDH). Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a...
The gap-repair model proposes that P elements move via a conservative, ``cut-and-paste'' mechanism followed by double-strand gap repair, using either the sister chromatid or homolog as the repair...
McCarron, M., Duttaroy, A., Doughty, G., Chovnick, A.
P element dysgenesis-associated male recombination in Drosophila was examined with a selective system focused upon a section of the third chromosome divided into eight recombination segments. Tests...
Meiotic Gene Conversion Tract Length Distribution within the Rosy Locus of Drosophila Melanogaster
Hilliker, A. J., Harauz, G., Reaume, A. G., Gray, M., Clark, S. H., Chovnick, A.
Employing extensive co-conversion data for selected and unselected sites of known molecular location in the rosy locus of Drosophila melanogaster, we determine the parameters of meiotic gene...
Chovnick, A., Gelbart, W., McCarron, M., Osmond, B., Candido, E. P. M., Baillie, D. L.
From a collection of electrophoretic variants of XDH obtained from laboratory strains and natural populations, a stock was isolated that was associated with much greater than normal levels of XDH...
McCarron, M., O'Donnell, J., Chovnick, A., Bhullar, B. S., Hewitt, J., Candido, E. P. M.
The present report summarizes our recent progress in the genetic dissection of an elementary genetic unit in a higher organism, the rosy locus (ry:3–52.0) in Drosophila melanogaster. Pursuing the...
Clark, S. H., Daniels, S., Rushlow, C. A., Hilliker, A. J., Chovnick, A.
Prior reports from this laboratory have described the experimental basis for our understanding of the genetic organization of the rosy locus (ry:3-52.0) of Drosophila melanogaster, as a bipartite...