We report the cloning and functional analysis of a complete clone for the third member of the mouse mdr gene family, mdr3. Nucleotide and predicted amino acid sequence analyses showed that the three...
Croop, J M, Raymond, M, Haber, D, Devault, A, Arceci, R J, Gros, P, ...
The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate...
Lepage, P, Devault, A, Gros, P
In multidrug-resistant (MDR) derivatives of the mouse lymphoid tumor P388, the emergence of MDR is associated with overexpression and transcriptional activation of the mdr3 gene, either in the...
Devault, A, Martinez, A M, Fesquet, D, Labbé, J C, Morin, N, Tassan, J P, ...
The kinase responsible for Thr161-Thr160 phosphorylation and activation of cdc2/cdk2 (CAK:cdk-activating kinase) has been shown previously to comprise at least two subunits, cdk7 and cyclin H. An...
Labbé, J C, Martinez, A M, Fesquet, D, Capony, J P, Darbon, J M, Derancourt, J, ...
p40MO15, a cdc2-related protein, is the catalytic subunit of the kinase (CAK, cdk-activating kinase) responsible for Thr161/Thr160 phosphorylation and activation of cdk1/cdk2. We have found that...
Lorca, T, Galas, S, Fesquet, D, Devault, A, Cavadore, J C, Dorée, M
Exit from M phase, which requires cyclin degradation, is prevented from occurring in unfertilized eggs of vertebrates arrested at second meiotic metaphase due to a cytostatic factor recently...
Devault, A, Lazure, C, Nault, C, Le Moual, H, Seidah, N G, Chrétien, M, ...
Neutral endopeptidase (EC 3.4.24.11) is a major constituent of kidney brush border membranes. It is also present in the brain where it has been shown to be involved in the inactivation of opioid...
Lorca, T, Labbé, J C, Devault, A, Fesquet, D, Capony, J P, Cavadore, J C, ...
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase....
We report the cloning and functional analysis of a complete clone for the third member of the mouse mdr gene family, mdr3. Nucleotide and predicted amino acid sequence analyses showed that the three...
Croop, J M, Raymond, M, Haber, D, Devault, A, Arceci, R J, Gros, P, ...
The gene responsible for multidrug resistance (mdr), which encodes the P-glycoprotein, is a member of a multigene family. We have identified distinct mdr gene transcripts encoded by three separate...
Lepage, P, Devault, A, Gros, P
In multidrug-resistant (MDR) derivatives of the mouse lymphoid tumor P388, the emergence of MDR is associated with overexpression and transcriptional activation of the mdr3 gene, either in the...
Devault, A, Martinez, A M, Fesquet, D, Labbé, J C, Morin, N, Tassan, J P, ...
The kinase responsible for Thr161-Thr160 phosphorylation and activation of cdc2/cdk2 (CAK:cdk-activating kinase) has been shown previously to comprise at least two subunits, cdk7 and cyclin H. An...
Labbé, J C, Martinez, A M, Fesquet, D, Capony, J P, Darbon, J M, Derancourt, J, ...
p40MO15, a cdc2-related protein, is the catalytic subunit of the kinase (CAK, cdk-activating kinase) responsible for Thr161/Thr160 phosphorylation and activation of cdk1/cdk2. We have found that...
Lorca, T, Galas, S, Fesquet, D, Devault, A, Cavadore, J C, Dorée, M
Exit from M phase, which requires cyclin degradation, is prevented from occurring in unfertilized eggs of vertebrates arrested at second meiotic metaphase due to a cytostatic factor recently...
Devault, A, Lazure, C, Nault, C, Le Moual, H, Seidah, N G, Chrétien, M, ...
Neutral endopeptidase (EC 3.4.24.11) is a major constituent of kidney brush border membranes. It is also present in the brain where it has been shown to be involved in the inactivation of opioid...
Lorca, T, Labbé, J C, Devault, A, Fesquet, D, Capony, J P, Cavadore, J C, ...
Exit from metaphase of the cell cycle requires inactivation of MPF, a stoichiometric complex between the cdc2 catalytic and the cyclin B regulatory subunits, as well as that of cyclin A-cdc2 kinase....
Steady state serum concentrations of pravastatin and digoxin when given in combination.
Triscari, J, Swanson, B N, Willard, D A, Cohen, A I, Devault, A, Pan, H Y
Pravastatin is an HMG CoA reductase inhibitor used in the treatment of hypercholesterolaemia. The steady state pharmacokinetics of pravastatin (20 mg) and digoxin (0.2 mg) were evaluated in 18...