Nielsen, K H, Papageorge, A G, Vass, W C, Willumsen, B M, Lowy, D R
We have compared aspects of the mouse sos1 (msos1) and msos2 genes, which encode widely expressed, closely related Ras-specific exchange factors. Although an msos1 plasmid did not induce phenotypic...
DeClue, J E, Stone, J C, Blanchard, R A, Papageorge, A G, Martin, P, Zhang, K, ...
A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature...
Willumsen, B M, Vass, W C, Velu, T J, Papageorge, A G, Schiller, J T, Lowy, D R
We have previously used a series of insertion-deletion mutants of the mutationally activated v-rasH gene to identify several regions of the encoded protein that are dispensable for cellular...
Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.
Cen, H, Papageorge, A G, Vass, W C, Zhang, K E, Lowy, D R
Serum stimulates cells to increase their proportion of Ras protein in the active GTP-bound state. We have recently identified four types (I to IV) of apparently full-length cDNAs from a single...
Papageorge, A G, Willumsen, B M, Johnsen, M, Kung, H F, Stacey, D W, Vass, W C, ...
Microinjection of monoclonal antibody Y13-259, which reacts with all known mammalian and yeast ras-encoded proteins, has previously been shown to prevent NIH 3T3 cells from entering the S phase (L....
Mutational analysis of a ras catalytic domain.
Willumsen, B M, Papageorge, A G, Kung, H F, Bekesi, E, Robins, T, Johnsen, M, ...
We used linker insertion-deletion mutagenesis to study the catalytic domain of the Harvey murine sarcoma virus v-rasH transforming protein, which is closely related to the cellular rasH protein. The...
Papageorge, A G, Defeo-Jones, D, Robinson, P, Temeles, G, Scolnick, E M
A family of normal vertebrate genes and oncogenes has been called the ras gene family. The name ras was assigned to this gene family based on the species of origin of the viral oncogenes of the...
Willumsen, B M, Papageorge, A G, Hubbert, N, Bekesi, E, Kung, H F, Lowy, D R
The mammalian p21 ras proteins contain a 20-amino acid region that is highly divergent, in contrast to the strong sequence conservation that is common to other regions of these proteins. This major...
Cen, H, Papageorge, A G, Zippel, R, Lowy, D R, Zhang, K
In Saccharomyces cerevisiae, the product of the CDC25 gene is an essential Ras activator that appears to function by stimulating guanine nucleotide exchange on Ras. Using the ability of a mouse cDNA...
Willumsen, B M, Norris, K, Papageorge, A G, Hubbert, N L, Lowy, D R
Previous studies of premature chain termination mutants and in frame deletion mutants of the p21 ras transforming protein encoded by the transforming gene of Harvey murine sarcoma virus (Ha-MuSV)...
Early regulation of membrane excitability by ras oncogene proteins.
Collin, C, Papageorge, A G, Sakakibara, M, Huddie, P L, Lowy, D R, Alkon, D L
Two electrode voltage clamp conditions were used to study the early effects on ionic membrane channels of the intracellularly injected proto-oncogenic form of c-Ha-ras (c-ras) and its oncogenic...
Nielsen, K H, Papageorge, A G, Vass, W C, Willumsen, B M, Lowy, D R
We have compared aspects of the mouse sos1 (msos1) and msos2 genes, which encode widely expressed, closely related Ras-specific exchange factors. Although an msos1 plasmid did not induce phenotypic...
DeClue, J E, Stone, J C, Blanchard, R A, Papageorge, A G, Martin, P, Zhang, K, ...
A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature...
Willumsen, B M, Vass, W C, Velu, T J, Papageorge, A G, Schiller, J T, Lowy, D R
We have previously used a series of insertion-deletion mutants of the mutationally activated v-rasH gene to identify several regions of the encoded protein that are dispensable for cellular...
Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.
Cen, H, Papageorge, A G, Vass, W C, Zhang, K E, Lowy, D R
Serum stimulates cells to increase their proportion of Ras protein in the active GTP-bound state. We have recently identified four types (I to IV) of apparently full-length cDNAs from a single...
Papageorge, A G, Willumsen, B M, Johnsen, M, Kung, H F, Stacey, D W, Vass, W C, ...
Microinjection of monoclonal antibody Y13-259, which reacts with all known mammalian and yeast ras-encoded proteins, has previously been shown to prevent NIH 3T3 cells from entering the S phase (L....
Mutational analysis of a ras catalytic domain.
Willumsen, B M, Papageorge, A G, Kung, H F, Bekesi, E, Robins, T, Johnsen, M, ...
We used linker insertion-deletion mutagenesis to study the catalytic domain of the Harvey murine sarcoma virus v-rasH transforming protein, which is closely related to the cellular rasH protein. The...
Papageorge, A G, Defeo-Jones, D, Robinson, P, Temeles, G, Scolnick, E M
A family of normal vertebrate genes and oncogenes has been called the ras gene family. The name ras was assigned to this gene family based on the species of origin of the viral oncogenes of the...
Willumsen, B M, Papageorge, A G, Hubbert, N, Bekesi, E, Kung, H F, Lowy, D R
The mammalian p21 ras proteins contain a 20-amino acid region that is highly divergent, in contrast to the strong sequence conservation that is common to other regions of these proteins. This major...
Cen, H, Papageorge, A G, Zippel, R, Lowy, D R, Zhang, K
In Saccharomyces cerevisiae, the product of the CDC25 gene is an essential Ras activator that appears to function by stimulating guanine nucleotide exchange on Ras. Using the ability of a mouse cDNA...
Willumsen, B M, Norris, K, Papageorge, A G, Hubbert, N L, Lowy, D R
Previous studies of premature chain termination mutants and in frame deletion mutants of the p21 ras transforming protein encoded by the transforming gene of Harvey murine sarcoma virus (Ha-MuSV)...
Early regulation of membrane excitability by ras oncogene proteins.
Collin, C, Papageorge, A G, Sakakibara, M, Huddie, P L, Lowy, D R, Alkon, D L
Two electrode voltage clamp conditions were used to study the early effects on ionic membrane channels of the intracellularly injected proto-oncogenic form of c-Ha-ras (c-ras) and its oncogenic...