Passarella, D., Giardini, A., Peretto, B., Fontana, G., Sacchetti, A., Silvani, A., ...
A series of novel hybrid compounds obtained by the attachment of anhydrovinblastine, vinorelbine, and vindoline to thiocolchicine, podophyllotoxin, and baccatin III are described. Two types of diacyl...
Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids (2004)
Danieli, B, Giardini, A, Lesma, G, Passarella, D, Silvani, A, Appendino, G, ...
The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but,...