Scientific Commons: A. Hofman

Coffee Consumption and Coronary Calcification: The Rotterdam Coronary Calcification Study (2008)

Vliegenthart, R., Hofman, A., Oudkerk, M., Witteman, J.C.M., ...

Background¿ The role of coffee in the cardiovascular system is not yet clear. We examined the relation of coffee intake with coronary calcification in a population-based cohort. Methods and...

Dairy Intake and Incident Hypertension: the Rotterdam Study (2008)

Engberink, M.F., Hendriksen, M.A.H., Hofman, A., Witteman, J.C.M., Geleijnse, J.M.

Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study (2007)

Geleijnse, J.M., Witteman, J.C.M., Stijnen, T., Kloos, M.W., Hofman, A., Grobbee, D.E.

Background Dietary electrolytes influence blood pressure, but their effect on clinical outcomes remains to be established. We examined sodium and potassium intake in relation to cardiovascular...

Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or ß-blockers (2007)

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Yazdanpanah, M., Danser, A.H.J., ...

Angiotensinogen is an essential component of the renin-angiotensin system. ACE-inhibitors and b-blockers both have a direct influence on this system. To investigate whether the association between...

Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or ß-blockers and the risk of atherosclerosis (2007)

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Hofman, A., Duijn, C.M. Van, Boer, A. De, ...

Aims: To investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen M235T or angiotensin II receptor type 1 573C/T polymorphism modify the risk of...

Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study (2006)

Ikram, M.K., Janssen, J.A., Roos, A.M., Rietveld, I., Witteman, J.C., Breteler, M.M., ...

The association between a smaller retinal arteriolar-to-venular ratio (AVR) and incident diabetes may be due to arteriolar narrowing, venular dilatation, or both. We investigated associations between...

An IGF-I gene polymorphism modifies the risk of diabetic retinopathy (2006)

Rietveld, I., Ikram, M.K., Vingerling, J.R., Hofman, A., Pols, H.A.P., Lamberts, S.W.J., ...

The role of IGF-I in the pathogenesis of diabetic retinopathy is unclear. We studied, prospectively, the relationship between an IGF-I gene polymorphism, retinal vessel diameters, and incident...

Retinal vessel diameters and risk of hypertension - The Rotterdam Study (2006)

Ikram, M.K., Witteman, J.C.M., Vingerling, J.R., Breteler, M.M.B., Hofman, A.

Generalized retinal arteriolar narrowing is an important sign of systemic hypertension, and a lower arteriolar: venular diameter ratio predicts the risk of hypertension. We investigated whether this...

Response: Retinal vessel narrowing: A prehypertensive or masked hypertensive state? (2006)

Ikram, M.K., Witteman, J.C.M., Vingerling, J.R., Breteler, M.M.B., Hofman, A.

Response to are narrower or wider retinal venules associated with incident hypertension? (2006)

Ikram, M.K., Witteman, J.C.M., Vingerling, J.R., Breteler, M.M.B., Hofman, A.

Retinal vessel diameters and risk of impaired fasting glucose or diabetes - The Rotterdam study (2006)

Ikram, M.K., Roos, A.M.E., Rietveld, I., Witteman, J.C.M., Breteler, M.M.B., ...

The association between a smaller retinal arteriolar-to-venular ratio (AVR) and incident diabetes may be due to arteriolar narrowing, venular dilatation, or both. We investigated associations between...

Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study (2006)

Ikram, M.K., Jong, F.J. De, Dijk, E.J. Van, Prins, N.D., Hofman, A., Breteler, M.M.B., ...

The direct visualization of retinal vessels provides a unique opportunity to study cerebral small vessel disease, because these vessels share many features. It was reported that persons with smaller...

Retinal vessel diameters and risk of stroke - The Rotterdam Study (2006)

Ikram, M.K., Jong, F.J. De, Bos, M.J., Vingerling, J.R., Hofman, A., Koudstaal, P.J., ...

Background: Retinal vessels may provide information on cerebral vascular pathology, because they share many features with cerebral vessels. A smaller ratio of the retinal arteriolar-to-venular...

Atherosclerosis, C-reactive protein, and risk for open-angle glaucoma: The Rotterdam study (2006)

Voogd, S. De, Wolfs, R.C.W., Jansonius, N.M., Witteman, J.C.M., Hofman, A.

PURPOSE. To test the hypotheses that atherosclerosis and elevated serum C-reactive protein ( CRP) levels are risk factors for open-angle glaucoma ( OAG). METHODS. In a prospective, population-based...

Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study (2006)

Voogd, S. De, Ikram, M.K., Wolfs, R.C.W., Jansonius, N.M., Witteman, J.C.M., Hofman, A., ...

Purpose: To investigate whether diabetes mellitus is a risk factor for open-angle glaucoma (OAG). Design: Prospective population-based cohort study. Participants: Participants ages >= 55 years from...

A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study (2006)

Kardys, I., Klaver, C.C.W., Despriet, D.D.G., Bergen, A.A.B., Uitterlinden, A.G., Hofman, A., ...

Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration (2006)

Despriet, D.D.G., Klaver, C.C.W., Witteman, J.C.M., Bergen, A.A.B., Kardys, I., Maat, P.M. De, ...

Drug Costs Associated with Non-Adherence to Cholesterol Management Guidelines for Primary Prevention of Cardiovascular Disease in an Elderly Population (2006)

Gumbs, P.D., Verschuren, W.M.M., Mantel-Teeuwisse, A.K., Wit, A.G. De, Hofman, A., Trienekens, P.H., ...

Background: In The Netherlands, costs of HMG-CoA reductase inhibitor (statin) use have recently increased sharply compared with costs of other drugs. However, several studies have established both...

Drug-Gene Interaction Between the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Antihypertensive Therapy (2006)

Schelleman, H., Klungel, O.H., Duijn, C.M. Van, Witteman, J.C.M., Hofman, A., Boer, A. De, ...

BACKGROUND: Despite the availability of a variety of effective drugs, inadequate control of blood pressure is common. There are some indications that the angiotensin-converting enzyme (ACE) gene...

The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure (2006)

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Hofman, A., Duijn, C.M. Van, Boer, A. De, ...

Despite the availability of a variety of effective antihypertensive drugs, inadequate control of blood pressure is common in hypertensive patients. The aim of this study was investigate whether the...

Prescribing behaviour according to Dutch and European guidelines on the management of hypercholesterolaemia (1992-1999) (2006)

Mantel-Teeuwisse, A.K., Klungel, O.H., Hofman, A., Verschuren, W.M.M., Trienekens, P.H., Porsius, A.J., ...

Background: The success of the full implementation of a new guideline may depend on the observed discrepancy between daily medical practice developed before the release of the guideline and new...

Diuretic-gene interaction and the risk of myocardial infarction and stroke (2006)

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., Duijn, C.M. Van, ...

This study investigates whether the interaction between diuretics and alphaadducin (ADD1) G460W or G-protein b3-subunit (GNB3) rs2301339 polymorphism modifies the risk of myocardial infarction (MI)...

Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors (2005)

Schelleman, H., Klungel, O.H., Duijn, C.M. Van, Witteman, J.C.M., Hofman, A., Boer, A. De, ...

Incidence of open-angle glaucoma in a general elderly population - The Rotterdam Study (2005)

Voogd, S. De, Ikram, M.K., Wolfs, R.C.W., Jansonius, K., Hofman, A.

Dietary intake of antioxidants and risk of age-related macular degeneration (2005)

Leeuwen, R. Van, Boekhoorn, S., Vingerling, J.R., Witteman, J.C.M., Klaver, C.C.W., Hofman, A., ...

Causes of incident visual field loss in a general elderly population - The Rotterdam study (2005)

Skenduli-Bala, E., Voogd, S. De, Wolfs, R.C.W., Leeuwen, R. Van, Ikram, M.K., Jonas, J.B., ...

Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: The Rotterdam Study (2005)

Ikram, M.K., Voogd, S. De, Wolfs, R.C.W., Hofman, A., Breteler, M.M.B., Hubbard, L.D., ...

Retinal vessel diameters and the risk of incident age-related macular disease - The Rotterdam Study (2005)

Ikram, M.K., Leeuwen, R. Van, Vingerling, J.R., Hofman, A.

Heterogeneity of the genetic risk in age-related macular disease - A population-based familial risk study (2005)

Assink, J.J.M., Klaver, C.C.W., Houwing-Duistermaat, J.J., Wolfs, R.C.W., Duijn, C.M. Van, Hofman, A., ...

Common carotid intima-media thickness and risk of acute myocardial infarction: the role of lumen diameter (2005)

Bots, M.L., Grobbee, D.E., Hofman, A., Witteman, J.C.

A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy (2005)

Bleumink, G.S., Schut, A.F., Sturkenboom, M.C., Witteman, J.C., Duijn, C.M. Van, ...

Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study (2005)

Fang, Y., Uitterlinden, A.G., Meurs, J.B. Van, Alesio, A. D', Jhamai, M., Zhao, H., ...

Polymorphisms of the vitamin D receptor gene (VDR) have been shown to be associated with several complex diseases, including osteoporosis, but the mechanisms are unknown and study results have been...

Homocysteine levels and the risk of osteoporotic fracture (2004)

Pluijm, S.M.F., Lindemans, J., ...

Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study (2004)

Ikram, M.K., Jong, F.J. De, Vingerling, J.R., Witteman, J.C.M., Hofman, A., Breteler, M.M.B., ...

Cholesterol and Age-related maculopathy: Is there a link? (2004)

Leeuwen, R. Van, Klaver, C.C.W., Vingerling, J.R., Hofman, A., Stricker, B.H.C., Duijn, C.M. Van, ...

Is Medication Use Associated with the Incidence of Early Age-Related Maculopathy? Pooled Findings from 3 Continents (2004)

Leeuwen, R. Van, Tomany, S.C., Wang, J.J., Klein, R., Mitchell, P., Hofman, A., ...

Pharmacoeconomic evaluation of testing for angiotensinconverting enzyme genotype before starting ß-hydrocy-ß-methylglutaryl coenzyme A reductase inhibitor therapy in men (2004)

Klungel, O.H., Stricker, B.H.Ch., Veenstra, D.L., Kastelein, J.J.P., Hofman, A., ...

Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism (2004)

Klungel, O.H., Leufkens, H.G.M., Boer, A. De, Stricker, B.H.Ch., Hofman, A., ...

Comparison of two methodologies to analyze exposure to statins in an observational study on effectiveness (2004)

Klungel, O.H., Stricker, B.H.Ch., Verschuren, W.M.M., Witteman, J.C.M., Stijnen, Th., ...

Dietary intake of menaquinone is associated with a reduced risk of coronary heart didease: the Rotterdam Study (2004)

Geleijnse, J.M., Vermeer, C., Grobbee, D.E., Schurgers, L.J., Knapen, M.H., Meer, I. Van Der, ...

Families and the natural history of blood pressure. A 27-year follow-up study (2004)

Ridder, M.A. De, Grobbee, D.E., Hofman, A., Witteman, J.C.

Is medication use associated with the incidence of early age-related maculopathy? Pooled findings from 3 continents (2004)

Leeuwen, R. Van, Tomany, S.C., Wang, J.J., Klein, R., Mitchell, P., Hofman, A., ...

Cholesterol and age-related macular degeneration: Is there a link? brief report (2004)

Leeuwen, R., Klaver, C.C.W., Vingerling, J.R., Hofman, A., Duijn, C.M. Van, Stricker, B.H.Ch., ...

Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study (2004)

Ikram, M.K., Jong, F.J. De, Vingerling, J.R., Witteman, J.C.M., Hofman, A., Breteler, F.J., ...

Homocysteine levels and the risk of osteoporotic fracture (2004)

Meurs, J.B. Van, Jonge, R. De, Lindemans, J., Groot, L.C., Uitterlinden, A.G., Hofman, A., ...

BACKGROUND: Very high plasma homocysteine levels are characteristic of homocystinuria, a rare autosomal recessive disease accompanied by the early onset of generalized osteoporosis. We therefore...

Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study (2004)

Zhai, G., Duijn, C.M. Van, Rivadeneira, F., Houwing-Duistermaat, J.J., Meulenbelt, I., Bijkerk, C., ...

OBJECTIVE: To examine the role of an IGF-I gene promoter polymorphism in the prevalence of radiographic osteoarthritis (ROA), and study its interaction with the COL2A1 gene. METHODS: Individuals...

Risk factors for coronary calcification in older subjects. The Rotterdam Coronary Calcification Study (2004)

Oei, H.H., Vliegenthart, R., Hofman, A., Oudkerk, M., Witteman, J.C.

AIMS: We examined associations between cardiovascular risk factors and coronary calcification assessed by electron-beam tomography (EBT) in an unselected population of older subjects. METHODS AND...

Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms (2004)

Schuit, S.C., Meurs, J.B. Van, Bergink, A.P., Klift, M. Van Der, Fang, Y., Leusink, G., ...

The estrogen receptor alpha gene (ESR1) is known to be involved in metabolic pathways influencing growth. We have performed two population-based association studies using three common polymorphisms...

A study of gene--environment interaction on the gene for angiotensin converting enzyme: a combined functional and population based approach (2004)

Sayed-Tabatabaei, F.A., Schut, A.F., Hofman, A., Bertoli-Avella, A.M., Vergeer, J., Witteman, J.C., ...

INTRODUCTION: Studies on the role of the insertion/deletion (I/D) polymorphism of the gene coding for angiotensin converting enzyme (ACE) in atherosclerosis have been inconsistent. In a...

Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study (2004)

Ikram, M.K., Jong, F.J. De, Vingerling, J.R., Witteman, J.C., Hofman, A., Breteler, M.M., ...

PURPOSE: A lower retinal arteriolar-to-venular ratio (AVR) has been suggested to reflect generalized arteriolar narrowing and to predict the risk of cardiovascular diseases. The contribution of the...

Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia (2004)

Heijer, T. Den, Vermeer, S.E., Dijk, E.J. Van, Prins, N.D., Koudstaal, P.J., Duijn, C.M. Van, ...

BACKGROUND: Consumers of light-to-moderate amounts of alcohol have a lower risk of dementia and, possibly, Alzheimer disease than do abstainers. Because vascular disease may contribute to symptoms of...

Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study (2004)

Geleijnse, J.M., Vermeer, C., Grobbee, D.E., Schurgers, L.J., Knapen, M.H., ...

Vitamin K-dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. Activation of these proteins via carboxylation depends on the availability of vitamin K....

Relative importance of vertebrates and invertebrates in epigeaic weed seed predation in organic cereal fields (2003)

Westerman, P.R., Hofman, A., Vet, L.E.M.

Exclosure trials were conducted in four organic cereal fields in The Netherlands in 1999 and 2000 to determine the relative importance of vertebrates and invertebrates in weed seed predation. The...

Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: The Rotterdam Study (2003)

Geleijnse, J.M., Grobbee, D.E., Hofman, A., Witteman, J.C.M.

Relative importance of vertebrates and invertebrates in epigeaic weed seed predation in organic cereal fields (2003)

Westerman, P.R., Hofman, A., Vet, L.E.M., Werf, W. Van Der

Is there a direct association between age-related eye diseases and mortality? The Rotterdam Study (2003)

Borger, P.H., Leeuwen, R. Van, Hulsman, C.A.A., Wolfs, R.C.W., Hofman, A., ...

Relationship between refraction and prevalent as well as incident age-related maculopathy: the Rotterdam Study (2003)

Ikram, M.K., Leeuwen, R. Van, Vingerling, J.R., Hofman, A.

The risk and Natural Course of Age-Related Maculopathy. Follow-Up at 6 ½ years in the Rotterdam Study (2003)

Leeuwen, R. Van, Klaver, C.C.W., Vingerling, J.R., Hofman, A.

Cholesterol lowering medication and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement (2003)

Leeuwen, R. Van, Vingerling, J.R., Hofman, A., Stricker, B.H.C.