Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection (1986)
We have investigated the contribution of each of the two adenovirus type 5 (Ad5) major early region lb (Elb) proteins in cell transformation and in lytic infection. An Ad5 El plasmid, in which the...
Jochemsen, A.G., Bernards, R.A., Kranen, H.J. Van, Houweling, A., Bos, J.L.
We have compared the capacities of the E1A regions of nononcogenic adenovirus type 5 (Ad5) and highly oncogenic Ad12 to cooperate with the EJ bladder carcinoma Ha-ras-1 oncogene in the transformation...
Oncogenicity by adenovirus is not determined by the transforming region only (1984)
Bernards, R.A., Vaessen, M.J., Houweling, A.
We have constructed a nondefective recombinant virus between the nononcogenic adenovirus 5 (Ad5) and the highly oncogenic Ad12. The recombinant genome consists essentially of Ad5 sequences, with the...
Expression of MHC genes in adenovirus-tranformed cells (1984)
Bernards, R.A., Oostra, B.A., Houweling, A., Jochemsen, A.G., Bos, J.L., ...
Class I MHC gene expression is drastically reduced in Ad12-, but not in Ad5-transformed primary cells of three different rodent species. Here we demonstrate that class I expression in...
Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids (1982)
Bernards, R.A., Houweling, A., Schrier, P.I., Bos, J.L.
Early region I (EI) of the human adenoviruses consists of two transcriptional units, EIa and EIb. We have constructed plasmids containing hybrid EI regions from the nononcogenic adenovirus type 5...
Jochemsen, A G, Bernards, R, Van Kranen, H J, Houweling, A, Bos, J L, Van Der Eb, A J
We have compared the capacities of the E1A regions of nononcogenic adenovirus type 5 (Ad5) and highly oncogenic Ad12 to cooperate with the EJ bladder carcinoma Ha-ras-1 oncogene in the transformation...
Oncogenicity by adenovirus is not determined by the transforming region only.
Bernards, R, De Leeuw, M G, Vaessen, M J, Houweling, A, Van Der Eb, A J
We have constructed a nondefective recombinant virus between the nononcogenic adenovirus 5 (Ad5) and the highly oncogenic Ad12. The recombinant genome consists essentially of Ad5 sequences, with the...
Offringa, R, Smits, A M, Houweling, A, Bos, J L, Van Der Eb, A J
The stromelysin (sml) gene encodes a secreted protease which degrades components of the extracellular matrix. Transformation of NRK49F cells by the E1A region of adenovirus (Ad) type 5 or 12 reduces...
Adenovirus E1A-mediated regulation of class I MHC expression.
Vaessen, R T, Houweling, A, Israel, A, Kourilsky, P, Van Der Eb, A J
Expression of class I MHC transplantation antigens has been shown to be reduced in baby rat kidney (BRK) cells transformed by highly oncogenic adenovirus type 12 (Ad12), as compared with...
Jochemsen, A G, Bernards, R, Van Kranen, H J, Houweling, A, Bos, J L, Van Der Eb, A J
We have compared the capacities of the E1A regions of nononcogenic adenovirus type 5 (Ad5) and highly oncogenic Ad12 to cooperate with the EJ bladder carcinoma Ha-ras-1 oncogene in the transformation...
Oncogenicity by adenovirus is not determined by the transforming region only.
Bernards, R, De Leeuw, M G, Vaessen, M J, Houweling, A, Van Der Eb, A J
We have constructed a nondefective recombinant virus between the nononcogenic adenovirus 5 (Ad5) and the highly oncogenic Ad12. The recombinant genome consists essentially of Ad5 sequences, with the...
Offringa, R, Smits, A M, Houweling, A, Bos, J L, Van Der Eb, A J
The stromelysin (sml) gene encodes a secreted protease which degrades components of the extracellular matrix. Transformation of NRK49F cells by the E1A region of adenovirus (Ad) type 5 or 12 reduces...
Adenovirus E1A-mediated regulation of class I MHC expression.
Vaessen, R T, Houweling, A, Israel, A, Kourilsky, P, Van Der Eb, A J
Expression of class I MHC transplantation antigens has been shown to be reduced in baby rat kidney (BRK) cells transformed by highly oncogenic adenovirus type 12 (Ad12), as compared with...