A. Inga

A functional genetic study identifies HAND1 mutations in septation defects of the human heart (2009)

Reamon-Buettner, S.M., Ciribilli, Y., Traverso, I., Kuhls, B., Inga, A., Borlak, J.

HAND1 is a basic helix-loop-helix (bHLH) transcription factor essential for mammalian heart development. Absence of Hand1 in mice results in embryonal lethality, as well as in a wide spectrum of...

A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts (2008)

Reamon-Büttner, S.M., Ciribilli, Y., Inga, A., Borlak, J.

Hypoplasia of the human heart is the most severe form of congenital heart disease (CHD) and usually lethal during early infancy. It is a leading cause of neonatal loss, especially in infants...

Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system (2005)

Inga, A., Reamon-Büttner, S.M., Borlak, J., Resnick, M.A.

Human heart development requires an orderly coordination of transcriptional programs, with the homeodomain protein NKX2-5 being one of the key transcription factors required for the differentiation...

Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer (1998)

Inga, A, Scott, G, Monti, P, Aprile, A, Abbondandolo, A, Burns, PA, ...

Simple identification of dominant p53 mutants by a yeast functional assay (1997)

Inga, A, Cresta, S, Monti, P, Aprile, A, Scott, G, Abbondandolo, A, ...