Molecular cloning and nucleotide sequence of rat lingual lipase cDNA.
Docherty, A J, Bodmer, M W, Angal, S, Verger, R, Riviere, C, Lowe, P A, ...
Purified rat lingual lipase (EC3113), a glycoprotein of approximate molecular weight 52,000, was used to generate polyclonal antibodies which were able to recognise the denatured and deglycosylated...
Edwards, D R, Murphy, G, Reynolds, J J, Whitham, S E, Docherty, A J, Angel, P, ...
Exposure of quiescent MRC-5 human fibroblasts to growth factors such as epidermal growth factor, basic fibroblast growth factor or embryonal carcinoma-derived growth factor resulted in the induction...
Murphy, G, Willenbrock, F, Ward, R V, Cockett, M I, Eaton, D, Docherty, A J
Recombinant 72 kDa gelatinase A and a truncated form lacking the C-terminal domain were shown to be activated by organomercurials and to possess similar activities towards a number of substrates. The...
Binding of gelatinases A and B to type-I collagen and other matrix components.
Allan, J A, Docherty, A J, Barker, P J, Huskisson, N S, Reynolds, J J, Murphy, G
Matrix sequestration of matrix metalloproteinases may be important for the facilitation of remodelling events and the migration of cells through the extracellular matrix. Using an ELISA technique we...
Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.
Hill, P A, Docherty, A J, Bottomley, K M, O'Connell, J P, Morphy, J R, Reynolds, J J, ...
Two low-molecular-mass inhibitors of matrix metalloproteinases (MMPs), CT1166, a concentration-dependent selective inhibitor of gelatinases A and B, and Ro 31-7467, a concentration-dependent...
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...
A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.
Murphy, G, Cockett, M I, Stephens, P E, Smith, B J, Docherty, A J
The latent forms of stromelysin and collagenase from human gingival fibroblasts were purified to homogeneity. These latent proenzymes underwent serial small reductions in Mr upon activation by...
Murphy, G, Cockett, M I, Ward, R V, Docherty, A J
The abilities of the matrix metalloproteinases 95 kDa and 72 kDa gelatinases (type IV collagenases), stromelysins-1 and -2 and punctuated metalloproteinase (PUMP) to degrade insoluble elastin, type...
Molecular cloning and nucleotide sequence of rat lingual lipase cDNA.
Docherty, A J, Bodmer, M W, Angal, S, Verger, R, Riviere, C, Lowe, P A, ...
Purified rat lingual lipase (EC3113), a glycoprotein of approximate molecular weight 52,000, was used to generate polyclonal antibodies which were able to recognise the denatured and deglycosylated...
Edwards, D R, Murphy, G, Reynolds, J J, Whitham, S E, Docherty, A J, Angel, P, ...
Exposure of quiescent MRC-5 human fibroblasts to growth factors such as epidermal growth factor, basic fibroblast growth factor or embryonal carcinoma-derived growth factor resulted in the induction...
Murphy, G, Willenbrock, F, Ward, R V, Cockett, M I, Eaton, D, Docherty, A J
Recombinant 72 kDa gelatinase A and a truncated form lacking the C-terminal domain were shown to be activated by organomercurials and to possess similar activities towards a number of substrates. The...
Binding of gelatinases A and B to type-I collagen and other matrix components.
Allan, J A, Docherty, A J, Barker, P J, Huskisson, N S, Reynolds, J J, Murphy, G
Matrix sequestration of matrix metalloproteinases may be important for the facilitation of remodelling events and the migration of cells through the extracellular matrix. Using an ELISA technique we...
Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.
Hill, P A, Docherty, A J, Bottomley, K M, O'Connell, J P, Morphy, J R, Reynolds, J J, ...
Two low-molecular-mass inhibitors of matrix metalloproteinases (MMPs), CT1166, a concentration-dependent selective inhibitor of gelatinases A and B, and Ro 31-7467, a concentration-dependent...
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...
A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.
Murphy, G, Cockett, M I, Stephens, P E, Smith, B J, Docherty, A J
The latent forms of stromelysin and collagenase from human gingival fibroblasts were purified to homogeneity. These latent proenzymes underwent serial small reductions in Mr upon activation by...
Murphy, G, Cockett, M I, Ward, R V, Docherty, A J
The abilities of the matrix metalloproteinases 95 kDa and 72 kDa gelatinases (type IV collagenases), stromelysins-1 and -2 and punctuated metalloproteinase (PUMP) to degrade insoluble elastin, type...