Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization (2006)
Thienen, J.V. Van,
Fledderus, J.O.,
Dekker, R.J.,
Rohlena, J.,
IJzendoorn, G.A. Van,
Kootstra, N.A.,
...
Objective: The transcription factor KLF2 is considered an important mediator of the anti-inflammatory and anti-thrombotic properties of the endothelium. KLF2 is absent from low-shear,...
Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes (2006)
Sprenger, R.R.,
Fontijn, R.D.,
Marle, J. Van,
Pannekoek, H.,
Horrevoets, A.J.G.
Lipid rafts and caveolae are biochemically similar, specialized domains of the PM (plasma membrane) that cluster specific proteins. However, they are morphologically distinct, implying different,...
Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function (2006)
Fontijn, R.D.,
Rohlena, J.,
Marle, J. Van,
Pannekoek, H.,
Horrevoets, A.J.G.
Members of the claudin family are involved in formation of barriers that control access to the paracellular space of epithelia. Likewise, endothelium-specific claudin-5 is involved in the function of...
The range of adaptation by collateral vessels after femoral artery occlusion (2006)
Eitenmueller, I.,
Volger, O.,
Kluge, A.,
Troidl, K.,
Barancik, M.,
Cai, W.J.,
...
Natural adaptation to femoral artery occlusion in animals by collateral artery growth restores only approximate to 35% of adenosine-recruitable maximal conductance (C-max) probably because initially...
KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium (2006)
Dekker, R.J.,
Boon, R.A.,
Rondaij, M.G.,
Kragt, A.,
Volger, O.L.,
Elderkamp, Y.W.,
...
Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes (2005)
Dekker, R.J.,
Thienen, J.V. Van,
Rohlena, J.,
Jager, S.C.,
Elderkamp, Y.W.,
Seppen, J.,
...
Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes (2005)
Dekker, R.J.,
Thienen, J.V. Van,
Rohlena, J.,
Jager, S.C.,
Elderkamp, Y.W.,
Seppen, J.,
...
Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry (2004)
Sprenger, R.R.,
Speijer, D.,
Back, J.W.,
Koster, C.G. De,
Pannekoek, H.,
Horrevoets, A.J.G.
The human endothelial cell plasma membrane harbors two subdomains of similar lipid composition, caveolae and rafts, both crucially involved in various essential cellular processes like transcytosis,...
Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry (2004)
Sprenger, R.R.,
Speijer, D.,
Back, J.W.,
Koster, C.G. De,
Pannekoek, H.,
Horrevoets, A.J.G.
Expression profiling of growing arteries/Hunting for new genes (2004)
Zimmermann, R.,
Boengler, K.,
Kampmann, A.,
Fernandez, B.,
Volger, O.,
Horrevoets, A.J.G.,
...
Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin (2003)
Kleemann, R.,
Princen, H.M.G.,
Emeis, J.J.,
Jukema, J.W.,
Fontijn, R.D.,
Horrevoets, A.J.G.,
...
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2) (2002)
Dekker, R.J.,
Soest, S. Van,
Fontijn, R.D.,
Salamanca, S.,
Groot, P.G. De,
Bavel, E.T. Van,
...
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2) (2002)
Dekker, R.J.,
Soest, S. Van,
Fontijn, R.D.,
Salamanca, S.,
Groot, P.G. De,
Bavel, E.T. Van,
...
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2) (2002)
Dekker, R.J.,
Soest, S. Van,
Fontijn, R.D.,
Salamanca, S.,
Groot, P.G. De,
Bavel, E.T. Van,
...
The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis (2001)
Fontijn, R.D.,
Goud, B.,
Echard, A.,
Jollivet, F.,
Marle, J. Van,
Pannekoek, H.,
...
The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis (2001)
Fontijn, R.D.,
Goud, B.,
Echard, A.,
Jollivet, F.,
Marle, J. Van,
Pannekoek, H.,
...
The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis (2001)
Fontijn, R.D.,
Goud, B.,
Echard, A.,
Jollivet, F.,
Marle, J. Van,
Pannekoek, H.,
...
Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes (1999)
Horrevoets, A.J.G.,
Fontijn, R.D.,
Zonneveld, A.J. Van,
Cate, J.W. Ten,
Pannekoek, H.
The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogenactivator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop (1999)
Dekker, R.J.,
Eichinger, A.,
Stoop, A.A.,
Bode, W.,
Pannekoek, H.,
Horrevoets, A.J.G.
Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes (1999)
Horrevoets, A.J.G.,
Fontijn, R.D.,
Zonneveld, A.J. Van,
Cate, J.W. Ten,
Pannekoek, H.
Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes (1999)
Horrevoets, A.J.G.,
Fontijn, R.D.,
Zonneveld, A.J. Van,
Cate, J.W. Ten,
Pannekoek, H.
The suicide substrate reaction between plasminogen activator inhibitor 1 and thrombin is regulated by the cofactors vitronectin and heparin (1997)
Meijer, M Van,
Smilde, A.E.,
Tans, G.,
Nesheim, M.E.,
Pannekoek, H.,
Horrevoets, A.J.G.
The solution phase interaction between apolipoprotein(a) and plasminogen inhibits the binding of plasminogen to a plasmin-modified fibrinogen surface (1997)
Sangrar, W.,
Gabel, B.R.,
Boffa, M.B.,
Walker, J.B.,
Hancock, M.A.,
Marcovina, S.M.,
...