Krause, E-G, Bartel, S, Vetter, D, Karczewski, P, Russell, F D, Kaumann, A J, ...
No abstract available.
Sarsero, D, Russell, F D, Lynham, J A, Rabnott, G, Yang, I, Fong, K M, ...
Two forms of the activated #1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such...
Oostendorp, J., Preitner, F., Moffatt, J., Jimenez, M., Giacobino, J. P., Molenaar, P., ...
1 The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor...
Molenaar, P., Bartel, S., Cochrane, A., Vetter, D., Jalali, H., Pohlner, P., ...
Background-In adult human heart, both beta(1)- and beta(2)-adrenergic receptors mediate hastening of relaxation; however, it is unknown whether this also occurs in infant heart. We compared the...
Burrell, K. M., Molenaar, P., Dawson, P. J., Kaumann, A. J.
It is known that binding sites with endothelin(A) (ET)(A) and ETB receptor characteristics coexist in human heart but little is known about the receptors that mediate cardiostimulant effects of ET...
Oostendorp, J., Preitner, F., Moffatt, J., Jimenez, M., Giacobino, J. P., Molenaar, P., ...
1 The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor...
Molenaar, P., Bartel, S., Cochrane, A., Vetter, D., Jalali, H., Pohlner, P., ...
Background-In adult human heart, both beta(1)- and beta(2)-adrenergic receptors mediate hastening of relaxation; however, it is unknown whether this also occurs in infant heart. We compared the...
Burrell, K. M., Molenaar, P., Dawson, P. J., Kaumann, A. J.
It is known that binding sites with endothelin(A) (ET)(A) and ETB receptor characteristics coexist in human heart but little is known about the receptors that mediate cardiostimulant effects of ET...
Sarsero, D., Molenaar, P., Kaumann, A. J., Freestone, N. S.
1 We identified putative beta(4)-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (-)-CGP 12177 and (+/-)-cyanopindolol and demonstrated increased Ca2+...
Sarsero, D., Molenaar, P., Kaumann, A. J., Freestone, N. S.
1 We identified putative beta(4)-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (-)-CGP 12177 and (+/-)-cyanopindolol and demonstrated increased Ca2+...
Kaumann, A. J., Hall, J. A., Murray, K. J., Wells, F. C., Brown, M. J.
The stimulant effects of adrenaline and noradrenaline on contractile force and adenylate cyclase, mediated through β1- and β2-adrenoceptors, are analysed in isolated atrial and ventricular...
Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors.
Levy, F O, Zhu, X, Kaumann, A J, Birnbaumer, L
We investigated the relative activity at which fully occupied human beta 1- and beta 2-adrenergic receptors (beta 1AR and beta 2AR) activate the stimulatory G protein (Gs)/adenylyl cyclase (AC)...
Birnbaumer, L, Levy, F O, Zhu, X, Kaumann, A J
Through co-expression of the human beta 1 and beta 2 adrenergic receptors in a single tester cell (the murine L fibroblast) and through assaying the effect of the beta 1 and beta 2 selective blockers...
Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors.
Levy, F O, Zhu, X, Kaumann, A J, Birnbaumer, L
We investigated the relative activity at which fully occupied human beta 1- and beta 2-adrenergic receptors (beta 1AR and beta 2AR) activate the stimulatory G protein (Gs)/adenylyl cyclase (AC)...
Birnbaumer, L, Levy, F O, Zhu, X, Kaumann, A J
Through co-expression of the human beta 1 and beta 2 adrenergic receptors in a single tester cell (the murine L fibroblast) and through assaying the effect of the beta 1 and beta 2 selective blockers...
Verheggen, R, Hundeshagen, A G, Brown, A M, Schindler, M, Kaumann, A J
In the human temporal artery both 5-HT1-like and 5-HT2A receptors mediate the contractile effects of 5-hydroxytryptamine (5-HT) and we have suggested that the 5-HT1-like receptors resemble more...
Joseph, S S, Lynham, J A, Grace, A A, Colledge, W H, Kaumann, A J
Substitution of arginine by glycine at position 389, a frequent β1-adrenoceptor polymorphism, reduces adenylyl cyclase stimulation by (−)-isoprenaline. β1-Adrenoceptors mediate the effects of...
Inhibition of the sodium pump by cardioactive DPI 201-106.
Kaumann, A. J., Richards, D. E., Russell, D. A.
The effects of DPI 201-106 were examined on contractions of papillary muscles from the right ventricle of feline heart, on [3H]-ouabain binding and Na+, K+-ATPase activity in feline ventricular...
Lemoine, H., Schönell, H., Kaumann, A. J.
1. (-)-Atenolol was used as a tool to assess the function of beta 1- and beta 2-adrenoceptors in human heart. Right atrial and left ventricular preparations from patients undergoing open heart...
Brown, A. M., Patch, T. L., Kaumann, A. J.
1. Fozard & Gray (1989) proposed that migraine is mediated by stimulation of 5-HT1C receptors. We have examined the interaction of two effective anti-migraine agents, ergotamine and dihydroergotamine...
Kaumann, A. J., Lynham, J. A., Brown, A. M.
1. We investigated the affinity of SB 207710 for sinoatrial 5-HT4 receptors and the density of right atrial 5-HT4 receptors with [125I]-SB 207710 in right atria of new-born piglets. 2. SB 207710...
Verheggen, R., Freudenthaler, S., Meyer-Dulheuer, F., Kaumann, A. J.
1. We investigated the hypothesis that, as in some other large human arteries, 5-HT-induced contraction of the temporal artery is mediated through two co-existing receptor populations, 5-HT1-like-...
1. The inotropic effects of (-)-4-(3-t-butylamino-2-hydroxypropoxy)benzimidazol-2-one ((-)-CGP 12177), an antagonist for beta 1- and beta 2-adrenoceptors as well as an agonist for beta...
1. The heart of several species including man contains atypical beta-adrenoceptors, in addition to coexisting beta 1- and beta 2-adrenoceptors. We now asked the question whether or not the third...
1. The amplification of vasoconstrictor effects of several agonists and sympathetic nerve stimulation, caused by 5-HT2 receptor activation, was studied in the autoperfused mesenteric circulation of...
Mode of action of (-)-pindolol on feline and human myocardium.
(-)-Pindolol antagonized competitively and to a similar extent the positive inotropic effects of both (-)-noradrenaline and (-)-adrenaline in human ventricular preparations. An equilibrium...
Cummings, S. A., Groszmann, R. J., Kaumann, A. J.
Isolated superior mesenteric veins from portal hypertensive rats were 3 to 10 times more sensitive to 5-hydroxytryptamine (5-HT) and 3 times less sensitive to (-)-noradrenaline than veins from...
Relationship between beta-adrenoceptors and calcium channels in human ventricular myocardium.
The stoichiometric relationship between adrenoceptors and saturable binding sites for 1,4-dihydropyridines in calcium channels was investigated in human ventricular myocardium. Membrane particles...
A 5-hydroxytryptamine receptor in human atrium.
Kaumann, A. J., Sanders, L., Brown, A. M., Murray, K. J., Brown, M. J.
1. The effects of 5-hydroxytryptamine (5-HT) were investigated on right atrial appendages obtained from patients treated with beta-adrenoceptor blocking agents who were undergoing open heart surgery....
Ferry, D. R., Glossmann, H., Kaumann, A. J.
Ventricular preparations from patients with mitral disease and hypertrophic obstructive cardiomyopathy (HOCM) were set up to contract isometrically. Ventricular membrane particles were also prepared...
WANG, T., KAUMANN, A. J., BROWN, M. J.
1The affinity of (−)-timolol for β1- and β2-adrenoceptors was determined on isolated atrial preparations from patients undergoing open heart surgery. The times for onset and offset of antagonism...
Ferro, A., Kaumann, A. J., Brown, M. J.
1. We have recently reported that patients taking beta 1-adrenoceptor-selective antagonists exhibit marked sensitization of beta 2-adrenoceptor responses but unaltered beta 1-adrenoceptor responses...
Blockade of human atrial 5-HT4 receptors by GR 113808.
1. The mode of antagonism of 5-hydroxytryptamine (5-HT)-induced positive inotropic effects by the highly selective 5-HT4 receptor antagonist GR 113808 ([1-[2-methylsulphonylamino...
Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium.
Medhurst, A. D., Kaumann, A. J.
1. In order to explore whether 5-HT4 receptor subtypes exist, we have characterized further the 5-HT4 receptor that mediates tachycardia in the piglet isolated right atrium. All experiments were...