POLYGENETIC DETERMINANTS OF CRANIOFACIAL ABNORMALITIES (2006)
Thomas A. Drake, Eric Schadt, Kambiz Hannani, J. Michael, Kelly Krass, Veronica Colinayo, ...
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Two polymorphisms for the human hepatic lipase (HL) gene (1988)
Heinzmann, C., Ladias, J., Antonarakis, S., Diep, A., Schotz, M., Lusis, A.J.
RFLP for the human lipoprotein lipase (LPL) gene: HindIII (1987)
Heinzmann, C., Ladias, J., Antonarakis, S., Kirchgessner, T., Schotz, M., Lusis, A.J.
Complete cDNA and derived protein sequence of human apolipoprotein B-100 (1986)
Knott, T.J., Wallis, S.C., Powell, L.M., Pease, R.J., Lusis, A.J., Blackhart, B., ...
Ivandic, B T, Qiao, J H, Machleder, D, Liao, F, Drake, T A, Lusis, A J
Dystrophic cardiac calcinosis, an age-related cardiomyopathy that occurs among certain inbred strains of mice, involves myocardial injury, necrosis, and calcification. Using a complete linkage map...
Garcia, J A, Ou, S H, Wu, F, Lusis, A J, Sparkes, R S, Gaynor, R B
A critical regulatory element in many promoters transcribed by RNA polymerase II is the "TATA" box, which is located 25-30 nucleotides upstream of the transcription initiation site. TFIID is a...
Purcell-Huynh, D A, Weinreb, A, Castellani, L W, Mehrabian, M, Doolittle, M H, Lusis, A J
A genetic cross was constructed from two parental inbred strains of mice, NZB/BINJ and SM/J, which differ markedly in their plasma lipoprotein levels. Plasma lipid and apolipoprotein values were...
Qiao, J H, Welch, C L, Xie, P Z, Fishbein, M C, Lusis, A J
Lipofuscin pigment, a terminal oxidation product, accumulates within cells during the normal aging process and under certain pathological conditions. We have analyzed a genetic cross between two...
Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium.
Schwartz, D, Andalibi, A, Chaverri-Almada, L, Berliner, J A, Kirchgessner, T, Fang, Z T, ...
We have previously shown that treatment of endothelial cells with minimally modified LDL (MM-LDL) induces the binding of monocytes to unknown endothelial receptor molecules. We now report that a...
Warden, C H, Fisler, J S, Pace, M J, Svenson, K L, Lusis, A J
We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238)....
Navab, M, Liao, F, Hough, G P, Ross, L A, Van Lenten, B J, Rajavashisth, T B, ...
Medium from cocultures of human aortic endothelial cells (HAEC) and smooth muscle cells (HASMC) taken from the same donor contained approximately two- to fourfold more macrophage colony-stimulating...
Identification of four chromosomal loci determining obesity in a multifactorial mouse model.
Warden, C H, Fisler, J S, Shoemaker, S M, Wen, P Z, Svenson, K L, Pace, M J, ...
We previously described a new mouse model for multigenic obesity, designated BSB. We now report the use of a complete linkage map approach to identify loci contributing to body fat and other traits...
Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo.
Van Lenten, B J, Prieve, J, Navab, M, Hama, S, Lusis, A J, Fogelman, A M
Iron promotes cellular damage via its capacity to catalyze hydroxyl radical formation and by peroxidation of unsaturated lipids. The major cellular iron storage depot, ferritin, acts as a critical...
Liao, F, Andalibi, A, Qiao, J H, Allayee, H, Fogelman, A M, Lusis, A J
In a previous survey of inbred mouse strains on an atherogenic diet, we observed that the susceptibility to aortic atherosclerotic lesion formation was associated with the accumulation of lipid...
Minimally modified low density lipoprotein is biologically active in vivo in mice.
Liao, F, Berliner, J A, Mehrabian, M, Navab, M, Demer, L L, Lusis, A J, ...
Minimally modified low density lipoprotein (MM-LDL), derived by mild iron oxidation or prolonged storage at 4 degrees C, has been shown to induce certain inflammatory responses in vascular cells in...
Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA.
Rajavashisth, T B, Eng, R, Shadduck, R K, Waheed, A, Ben-Avram, C M, Shively, J E, ...
Macrophage colony-stimulating factor (CSF-1) stimulates the production of macrophages from bone marrow progenitor cells. We have identified a cDNA clone for murine CSF-1 by antibody screening of a...
Paigen, B, Mitchell, D, Reue, K, Morrow, A, Lusis, A J, LeBoeuf, R C
High density lipoprotein (HDL) is the major plasma lipoprotein found in mice fed normal laboratory chow containing 4% fat. When female mice from some inbred strains, such as C57BL/6, are fed a high...
RFLP for the human lipoprotein lipase (LPL) gene: HindIII.
Heinzmann, C, Ladias, J, Antonarakis, S, Kirchgessner, T, Schotz, M, Lusis, A J
Complete cDNA and derived protein sequence of human apolipoprotein B-100.
Knott, T J, Wallis, S C, Powell, L M, Pease, R J, Lusis, A J, Blackhart, B, ...
Lusis, A J, Heinzmann, C, Sparkes, R S, Scott, J, Knott, T J, Geller, R, ...
We report the regional mapping of human chromosome 19 genes for three apolipoproteins and a lipoprotein receptor as well as genes for three other markers. The regional mapping was made possible by...
Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet.
Fyfe, A I, Qiao, J H, Lusis, A J
Inbred strain C57BL/6J mice develop typical atherosclerotic fatty streaks in the aorta after 15 wk on a high fat, high cholesterol diet. To investigate the effects of the immune system on the...
Two polymorphisms for the human hepatic lipase (HL) gene.
Heinzmann, C, Ladias, J, Antonarakis, S, Diep, A, Schotz, M, Lusis, A J
Nucleotide sequence of rat adipose hormone sensitive lipase cDNA.
Holm, C, Kirchgessner, T G, Svenson, K L, Lusis, A J, Belfrage, P, Schotz, M C
Production of erythroid-potentiating activity by a human T-lymphoblast cell line.
Golde, D W, Bersch, N, Quan, S G, Lusis, A J
We derived a human T-lymphoblast cell line (Mo) that constitutively elaborates certain lymphokines. The Mo cells produce a colony-stimulating factor necessary for the growth of human...
Granulocyte-macrophage colony-stimulating factors (CSFs) have previously been shown to stimulate colony formation in soft agar culture by a human myelogenous leukemia cell line known as KG-1. We have...
Mouse apolipoprotein A-IV gene: nucleotide sequence and induction by a high-lipid diet.
Williams, S C, Bruckheimer, S M, Lusis, A J, LeBoeuf, R C, Kinniburgh, A J
Apolipoprotein A-IV (apo A-IV) functions in conjunction with other apolipoproteins to form lipoprotein particles which are involved in lipid homeostasis. In this report we present the nucleotide...
Trans-acting temporal locus within the beta-glucuronidase gene complex.
Lusis, A J, Chapman, V M, Wangenstein, R W, Paigen, K
Mice carrying the [Gus]H haplotype of the beta-glucuronidase gene complex have considerably decreased enzyme levels and a decreased rate of enzyme synthesis. This is now shown to result from the...
Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene.
Demmer, L A, Levin, M S, Elovson, J, Reuben, M A, Lusis, A J, Gordon, J I
Expression of the apolipoprotein B (apoB) gene was examined in a variety of fetal, neonatal, and adult rat tissues by probing RNA blots with a cloned rat apoB cDNA. Among 10 adult male tissues...
Lusis, A J, West, R, Mehrabian, M, Reuben, M A, LeBoeuf, R C, Kaptein, J S, ...
We report the cloning of cDNAs for rat liver apolipoprotein B (apo B) and the use of the cloned sequences to examine apo B expression at the level of mRNA in rat tissues. Fifteen putative apo B...
Amino-terminal amino acid sequence of murine colony-stimulating factor 1.
Ben-Avram, C M, Shively, J E, Shadduck, R K, Waheed, A, Rajavashisth, T, Lusis, A J
We report the amino acid composition, the NH2-terminal sequence, and the tryptic map by HPLC for murine L-cell colony-stimulating factor 1 (CSF-1). CSF-1 purified by affinity chromatography was...
Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.
Rajavashisth, T B, Kaptein, J S, Reue, K L, Lusis, A J
Apolipoprotein E (apo E) is responsible for the binding of very low density lipoprotein and chylomicron remnants to cellular receptors thereby removing them from circulation. We have isolated and...
Liao, F, Andalibi, A, DeBeer, F C, Fogelman, A M, Lusis, A J
A high fat, high cholesterol "atherogenic" diet induced considerably greater hepatic levels of conjugated dienes and expression of several inflammatory and oxidative stress responsive genes (JE, the...
Shih, D M, Gu, L, Hama, S, Xia, Y R, Navab, M, Fogelman, A M, ...
In an effort to identify genetic factors contributing to atherogenesis, we have studied inbred strains of mice that are susceptible (C57BL/6J) and resistant (C3H/HeJ) to diet-induced aortic fatty...
Wu, D A, Bu, X, Warden, C H, Shen, D D, Jeng, C Y, Sheu, W H, ...
Resistance to insulin-mediated glucose disposal is a common finding in patients with non-insulin-dependent diabetes mellitus (NIDDM), as well as in nondiabetic individuals with hypertension. In an...
Dallinga-Thie, G M, Rotter, J I, Cantor, R M, Bu, X, Lusis, A J, ...
Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder in Western societies. In a recent report (Dallinga-Thie, G.M., X.D. Bu, M. van Linde-Sibenius Trip, J.I. Rotter, A.J. Lusis,...
Machleder, D, Ivandic, B, Welch, C, Castellani, L, Reue, K, Lusis, A J
Inbred strains of mice differ in susceptibility to atherogenesis when challenged with a high fat, high cholesterol diet containing 0.5% cholic acid. Studies of recombinant inbred (RI) strains derived...
Cohen, R D, Castellani, L W, Qiao, J H, Van Lenten, B J, Lusis, A J, Reue, K
Transgenic mouse lines carrying several copies of the mouse apo A-IV gene were produced. Lipoprotein composition and function, and aortic lesion development were examined. Apo A-IV levels in the...
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
Navab, M, Hama-Levy, S, Van Lenten, B J, Fonarow, G C, Cardinez, C J, Castellani, L W, ...
We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL; apolipoprotein J (apoJ), and paraoxonase (PON). On an atherogenic diet, PON...
Castellani, L W, Navab, M, Van Lenten, B J, Hedrick, C C, Hama, S Y, Goto, A M, ...
Previous studies showed that transgenic mice overexpressing either apolipoprotein AI (apoAI) or apolipoprotein AII (apoAII), the major proteins of HDL, exhibited elevated levels of HDL cholesterol,...
Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.
Ishikawa, K, Navab, M, Leitinger, N, Fogelman, A M, Lusis, A J
Heme catabolic processes produce the antioxidants biliverdin and bilirubin, as well as the potent prooxidant free iron. Since these products have opposing effects on oxidative stress, it is not clear...
Lembertas, A V, Pérusse, L, Chagnon, Y C, Fisler, J S, Warden, C H, Purcell-Huynh, D A, ...
Chromosomal synteny between the mouse model and humans was used to map a gene for the complex trait of obesity. Analysis of NZB/BINJ x SM/J intercross mice located a quantitative trait locus (QTL)...
Mehrabian, M, Wen, P Z, Fisler, J, Davis, R C, Lusis, A J
We analyzed the inheritance of body fat, leptin levels, plasma lipoprotein levels, insulin levels, and related traits in an intercross between inbred mouse strains CAST/Ei and C57BL/6J. CAST/Ei mice...
Allayee, H, Aouizerat, B E, Cantor, R M, Dallinga-Thie, G M, Krauss, R M, Lanning, C D, ...
Small, dense LDL particles consistently have been associated with hypertriglyceridemia, premature coronary artery disease (CAD), and familial combined hyperlipidemia (FCH). Previously, we have...
Aouizerat, B E, Allayee, H, Cantor, R M, Davis, R C, Lanning, C D, Wen, P Z, ...
Familial combined hyperlipidemia (FCHL) is a common familial lipid disorder characterized by a variable pattern of elevated levels of plasma cholesterol and/or triglycerides. It is present in 10%-20%...
The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.
Sparkes, R S, Dizikes, G J, Klisak, I, Grody, W W, Mohandas, T, Heinzmann, C, ...
The human liver arginase gene, whose deficiency is responsible for argininemia (McKusick no. 20780), has been assigned to 6q23 through a combination of somatic cell hybrid analysis and in situ...
Ivandic, B T, Qiao, J H, Machleder, D, Liao, F, Drake, T A, Lusis, A J
Dystrophic cardiac calcinosis, an age-related cardiomyopathy that occurs among certain inbred strains of mice, involves myocardial injury, necrosis, and calcification. Using a complete linkage map...
Garcia, J A, Ou, S H, Wu, F, Lusis, A J, Sparkes, R S, Gaynor, R B
A critical regulatory element in many promoters transcribed by RNA polymerase II is the "TATA" box, which is located 25-30 nucleotides upstream of the transcription initiation site. TFIID is a...
Purcell-Huynh, D A, Weinreb, A, Castellani, L W, Mehrabian, M, Doolittle, M H, Lusis, A J
A genetic cross was constructed from two parental inbred strains of mice, NZB/BINJ and SM/J, which differ markedly in their plasma lipoprotein levels. Plasma lipid and apolipoprotein values were...
Qiao, J H, Welch, C L, Xie, P Z, Fishbein, M C, Lusis, A J
Lipofuscin pigment, a terminal oxidation product, accumulates within cells during the normal aging process and under certain pathological conditions. We have analyzed a genetic cross between two...
Role of the GRO family of chemokines in monocyte adhesion to MM-LDL-stimulated endothelium.
Schwartz, D, Andalibi, A, Chaverri-Almada, L, Berliner, J A, Kirchgessner, T, Fang, Z T, ...
We have previously shown that treatment of endothelial cells with minimally modified LDL (MM-LDL) induces the binding of monocytes to unknown endothelial receptor molecules. We now report that a...
Warden, C H, Fisler, J S, Pace, M J, Svenson, K L, Lusis, A J
We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238)....
Navab, M, Liao, F, Hough, G P, Ross, L A, Van Lenten, B J, Rajavashisth, T B, ...
Medium from cocultures of human aortic endothelial cells (HAEC) and smooth muscle cells (HASMC) taken from the same donor contained approximately two- to fourfold more macrophage colony-stimulating...
Identification of four chromosomal loci determining obesity in a multifactorial mouse model.
Warden, C H, Fisler, J S, Shoemaker, S M, Wen, P Z, Svenson, K L, Pace, M J, ...
We previously described a new mouse model for multigenic obesity, designated BSB. We now report the use of a complete linkage map approach to identify loci contributing to body fat and other traits...
Lipid-induced changes in intracellular iron homeostasis in vitro and in vivo.
Van Lenten, B J, Prieve, J, Navab, M, Hama, S, Lusis, A J, Fogelman, A M
Iron promotes cellular damage via its capacity to catalyze hydroxyl radical formation and by peroxidation of unsaturated lipids. The major cellular iron storage depot, ferritin, acts as a critical...
Liao, F, Andalibi, A, Qiao, J H, Allayee, H, Fogelman, A M, Lusis, A J
In a previous survey of inbred mouse strains on an atherogenic diet, we observed that the susceptibility to aortic atherosclerotic lesion formation was associated with the accumulation of lipid...
Minimally modified low density lipoprotein is biologically active in vivo in mice.
Liao, F, Berliner, J A, Mehrabian, M, Navab, M, Demer, L L, Lusis, A J, ...
Minimally modified low density lipoprotein (MM-LDL), derived by mild iron oxidation or prolonged storage at 4 degrees C, has been shown to induce certain inflammatory responses in vascular cells in...
Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA.
Rajavashisth, T B, Eng, R, Shadduck, R K, Waheed, A, Ben-Avram, C M, Shively, J E, ...
Macrophage colony-stimulating factor (CSF-1) stimulates the production of macrophages from bone marrow progenitor cells. We have identified a cDNA clone for murine CSF-1 by antibody screening of a...
Paigen, B, Mitchell, D, Reue, K, Morrow, A, Lusis, A J, LeBoeuf, R C
High density lipoprotein (HDL) is the major plasma lipoprotein found in mice fed normal laboratory chow containing 4% fat. When female mice from some inbred strains, such as C57BL/6, are fed a high...
RFLP for the human lipoprotein lipase (LPL) gene: HindIII.
Heinzmann, C, Ladias, J, Antonarakis, S, Kirchgessner, T, Schotz, M, Lusis, A J
Complete cDNA and derived protein sequence of human apolipoprotein B-100.
Knott, T J, Wallis, S C, Powell, L M, Pease, R J, Lusis, A J, Blackhart, B, ...
Lusis, A J, Heinzmann, C, Sparkes, R S, Scott, J, Knott, T J, Geller, R, ...
We report the regional mapping of human chromosome 19 genes for three apolipoproteins and a lipoprotein receptor as well as genes for three other markers. The regional mapping was made possible by...
Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet.
Fyfe, A I, Qiao, J H, Lusis, A J
Inbred strain C57BL/6J mice develop typical atherosclerotic fatty streaks in the aorta after 15 wk on a high fat, high cholesterol diet. To investigate the effects of the immune system on the...
Two polymorphisms for the human hepatic lipase (HL) gene.
Heinzmann, C, Ladias, J, Antonarakis, S, Diep, A, Schotz, M, Lusis, A J
Nucleotide sequence of rat adipose hormone sensitive lipase cDNA.
Holm, C, Kirchgessner, T G, Svenson, K L, Lusis, A J, Belfrage, P, Schotz, M C
Production of erythroid-potentiating activity by a human T-lymphoblast cell line.
Golde, D W, Bersch, N, Quan, S G, Lusis, A J
We derived a human T-lymphoblast cell line (Mo) that constitutively elaborates certain lymphokines. The Mo cells produce a colony-stimulating factor necessary for the growth of human...
Granulocyte-macrophage colony-stimulating factors (CSFs) have previously been shown to stimulate colony formation in soft agar culture by a human myelogenous leukemia cell line known as KG-1. We have...
Mouse apolipoprotein A-IV gene: nucleotide sequence and induction by a high-lipid diet.
Williams, S C, Bruckheimer, S M, Lusis, A J, LeBoeuf, R C, Kinniburgh, A J
Apolipoprotein A-IV (apo A-IV) functions in conjunction with other apolipoproteins to form lipoprotein particles which are involved in lipid homeostasis. In this report we present the nucleotide...
Trans-acting temporal locus within the beta-glucuronidase gene complex.
Lusis, A J, Chapman, V M, Wangenstein, R W, Paigen, K
Mice carrying the [Gus]H haplotype of the beta-glucuronidase gene complex have considerably decreased enzyme levels and a decreased rate of enzyme synthesis. This is now shown to result from the...
Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene.
Demmer, L A, Levin, M S, Elovson, J, Reuben, M A, Lusis, A J, Gordon, J I
Expression of the apolipoprotein B (apoB) gene was examined in a variety of fetal, neonatal, and adult rat tissues by probing RNA blots with a cloned rat apoB cDNA. Among 10 adult male tissues...
Lusis, A J, West, R, Mehrabian, M, Reuben, M A, LeBoeuf, R C, Kaptein, J S, ...
We report the cloning of cDNAs for rat liver apolipoprotein B (apo B) and the use of the cloned sequences to examine apo B expression at the level of mRNA in rat tissues. Fifteen putative apo B...
Amino-terminal amino acid sequence of murine colony-stimulating factor 1.
Ben-Avram, C M, Shively, J E, Shadduck, R K, Waheed, A, Rajavashisth, T, Lusis, A J
We report the amino acid composition, the NH2-terminal sequence, and the tryptic map by HPLC for murine L-cell colony-stimulating factor 1 (CSF-1). CSF-1 purified by affinity chromatography was...
Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit.
Rajavashisth, T B, Kaptein, J S, Reue, K L, Lusis, A J
Apolipoprotein E (apo E) is responsible for the binding of very low density lipoprotein and chylomicron remnants to cellular receptors thereby removing them from circulation. We have isolated and...
Liao, F, Andalibi, A, DeBeer, F C, Fogelman, A M, Lusis, A J
A high fat, high cholesterol "atherogenic" diet induced considerably greater hepatic levels of conjugated dienes and expression of several inflammatory and oxidative stress responsive genes (JE, the...
Shih, D M, Gu, L, Hama, S, Xia, Y R, Navab, M, Fogelman, A M, ...
In an effort to identify genetic factors contributing to atherogenesis, we have studied inbred strains of mice that are susceptible (C57BL/6J) and resistant (C3H/HeJ) to diet-induced aortic fatty...
Wu, D A, Bu, X, Warden, C H, Shen, D D, Jeng, C Y, Sheu, W H, ...
Resistance to insulin-mediated glucose disposal is a common finding in patients with non-insulin-dependent diabetes mellitus (NIDDM), as well as in nondiabetic individuals with hypertension. In an...
Dallinga-Thie, G M, Rotter, J I, Cantor, R M, Bu, X, Lusis, A J, ...
Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder in Western societies. In a recent report (Dallinga-Thie, G.M., X.D. Bu, M. van Linde-Sibenius Trip, J.I. Rotter, A.J. Lusis,...
Machleder, D, Ivandic, B, Welch, C, Castellani, L, Reue, K, Lusis, A J
Inbred strains of mice differ in susceptibility to atherogenesis when challenged with a high fat, high cholesterol diet containing 0.5% cholic acid. Studies of recombinant inbred (RI) strains derived...
Cohen, R D, Castellani, L W, Qiao, J H, Van Lenten, B J, Lusis, A J, Reue, K
Transgenic mouse lines carrying several copies of the mouse apo A-IV gene were produced. Lipoprotein composition and function, and aortic lesion development were examined. Apo A-IV levels in the...
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
Navab, M, Hama-Levy, S, Van Lenten, B J, Fonarow, G C, Cardinez, C J, Castellani, L W, ...
We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL; apolipoprotein J (apoJ), and paraoxonase (PON). On an atherogenic diet, PON...
Castellani, L W, Navab, M, Van Lenten, B J, Hedrick, C C, Hama, S Y, Goto, A M, ...
Previous studies showed that transgenic mice overexpressing either apolipoprotein AI (apoAI) or apolipoprotein AII (apoAII), the major proteins of HDL, exhibited elevated levels of HDL cholesterol,...
Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.
Ishikawa, K, Navab, M, Leitinger, N, Fogelman, A M, Lusis, A J
Heme catabolic processes produce the antioxidants biliverdin and bilirubin, as well as the potent prooxidant free iron. Since these products have opposing effects on oxidative stress, it is not clear...
Lembertas, A V, Pérusse, L, Chagnon, Y C, Fisler, J S, Warden, C H, Purcell-Huynh, D A, ...
Chromosomal synteny between the mouse model and humans was used to map a gene for the complex trait of obesity. Analysis of NZB/BINJ x SM/J intercross mice located a quantitative trait locus (QTL)...
Mehrabian, M, Wen, P Z, Fisler, J, Davis, R C, Lusis, A J
We analyzed the inheritance of body fat, leptin levels, plasma lipoprotein levels, insulin levels, and related traits in an intercross between inbred mouse strains CAST/Ei and C57BL/6J. CAST/Ei mice...
Allayee, H, Aouizerat, B E, Cantor, R M, Dallinga-Thie, G M, Krauss, R M, Lanning, C D, ...
Small, dense LDL particles consistently have been associated with hypertriglyceridemia, premature coronary artery disease (CAD), and familial combined hyperlipidemia (FCH). Previously, we have...
Aouizerat, B E, Allayee, H, Cantor, R M, Davis, R C, Lanning, C D, Wen, P Z, ...
Familial combined hyperlipidemia (FCHL) is a common familial lipid disorder characterized by a variable pattern of elevated levels of plasma cholesterol and/or triglycerides. It is present in 10%-20%...
The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.
Sparkes, R S, Dizikes, G J, Klisak, I, Grody, W W, Mohandas, T, Heinzmann, C, ...
The human liver arginase gene, whose deficiency is responsible for argininemia (McKusick no. 20780), has been assigned to 6q23 through a combination of somatic cell hybrid analysis and in situ...
DeMeester, C A, Bu, X, Gray, R J, Lusis, A J, Rotter, J I
Lipoprotein (a) (Lp[a]) is a cholesterol-rich lipoprotein resembling LDL but also containing a large polypeptide designated apolipoprotein (a) (apo[a]). Its levels are highly variable among...
Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.
Qiao, J. H., Tripathi, J., Mishra, N. K., Cai, Y., Tripathi, S., Wang, X. P., ...
Previous in vitro and in vivo studies have suggested that macrophage colony-stimulating factor (M-CSF) plays a role in atherogenesis. To examine this hypothesis, we have studied atherogenesis in...
Multilocus genetic determinants of LDL particle size in coronary artery disease families.
Rotter, J. I., Bu, X., Cantor, R. M., Warden, C. H., Brown, J., Gray, R. J., ...
Recent interest in atherosclerosis has focused on the genetic determinants of low-density lipoprotein (LDL) particle size, because of (i) the association of small dense LDL particles with a...