A. J. Ryan

Self-motile colloidal particles: from directed propulsion to random walk (2009)

Gough, Timothy D., Howse, J.R., Jones, R.A.L., Ryan, A.J.

No

Self-motile colloidal particles: from directed propulsion to random walk (2009)

Gough, Tim D., Howse, J.R., Jones, R.A.L., Ryan, A.J.

No

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer (2006)

Goodlad, R.A., Ryan, A.J., Wedge, S.R., Pyrah, I.T., Alferez, D., Poulsom, R., ...

The ApcMin/+ mouse model is a clinically relevant model of early intestinal cancer. We used AZD2171, an oral, highly potent and selective vascular endothelial growth factor (VEGF) signaling...

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer (2006)

Goodlad, R. A., Ryan, A. J., Wedge, S. R., Pyrah, I. T., Alferez, D., Poulsom, R., ...

The ApcMin/+ mouse model is a clinically relevant model of early intestinal cancer. We used AZD2171, an oral, highly potent and selective vascular endothelial growth factor (VEGF) signaling...

Selective repair of methylated purines in regions of chromatin DNA (1986)

Ryan, A.J., Billett, M.A., O'Connor, P.J.

The distribution of methylated purines in different regions of liver chromatin DNA has been examined after treating rats with [14C]dimethylnitrosamine (2 mg/kg). At different times after...

Preferential binding of the carcinogen benzo[a]pyrene to DNA in active chromatin and the nuclear matrix (1986)

Obi, F.O., Ryan, A.J., Billett, M.A.

Rat liver nuclei or hepatocytes were incubated with the proximate carcinogen, benzo[a]pyrene (BP) and its ultimate carcinogen, anti-benzo[a]pyrene-7, 8-dol-9,10-epoxide (BPDE. Following carcinogen...

7-Methylbenz[c]acridine: mutagenicity of some of its metabolites and derivatives, and the identification of trans-7-methylbenz[c]-acridine-3,4-dihydrodiol as a microsomal metabolite (1986)

Gill, J.H., Bonin, A.M., Podobna, E., Baker, R.S.U., Duke, C.C., Rosario, C.A., ...

The presence of the proposed proximate carcinogen, trans-3,4-dihydro-3,4-dihydroxy-7-methylbenz[c]acridine (7MBAC-3, 4-DHD) among the liver microsomal metabolites of 7-methylbenz[c]acridine (7MBAC)...

Metabolism of 7-methylbenz[c]acridine: comparison of rat liver and lung microsomal preparations and identification of some minor metabolites (1983)

Boux, L. J., Duke, C. C., Holder, G. M., Ireland, C. M., Ryan, A. J.

The metabolism of the carcinogenic polycydic aza-aromatic compound, 7-methylbenz[c]acridine, has been studied in lung and liver microsomal preparations obtained from control and induced rats. Minor...

Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel

Martinelli, M, Bonezzi, K, Riccardi, E, Kuhn, E, Frapolli, R, Zucchetti, M, ...

The clinical success of small-molecule vascular disrupting agents (VDAs) depends on their combination with conventional therapies. Scheduling and sequencing remain key issues in the design of...

ZD6474 – a novel inhibitor of VEGFR and EGFR tyrosine kinase activity

Ryan, A J, Wedge, S R

Angiogenesis is crucial for maintaining the supply of oxygen and nutrients required to support solid tumour growth. Inhibitors of tumour blood vessel formation are therefore being sought, in...

Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging

Robinson, S P, McIntyre, D J O, Checkley, D, Tessier, J J, Howe, F A, Griffiths, J R, ...

Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma

Hill, K J, Issa, J, Ashton, S E, Westwood, F R, Blakey, D C, ...

Vascular disrupting agents (VDAs) are able to affect selectively tumour endothelial cell morphology resulting in vessel occlusion and widespread tumour cell necrosis. However, single-agent antitumour...