Sergeant, Martin J., Li, J.J., Fox, C., Brookbank, N., Rea, D, Bugg, T.D., ...
Members of the carotenoid cleavage dioxygenase family catalyse the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signalling...
Resource Fugu ESTs: New Resources for Transcription Analysis and Genome Annotation (2008)
Melody S. Clark, Dan Peterson, Ra W. Clifton, A J. Thompson, Masahide Sasaki, ...
The draft Fugu rubripes genome was released in 2002, at which time relatively few cDNAs were available to aid in the annotation of genes. The data presented here describe the sequencing and analysis...
Fisniku, L. K., Brex, P. A., Altmann, D. R., Miszkiel, K. A., Benton, C. E., Lanyon, R., ...
Clinically isolated syndromes (CIS), such as optic neuritis, brainstem or spinal cord syndromes are frequently the first clinical presentations of multiple sclerosis. However, not all CIS patients...
Swanton, J.K., Rovira, A., Tintore, M., Altmann, D.R., Barkhof, F., Filippi, M., ...
Summary: Background: The 2001 and 2005 McDonald criteria allow MRI evidence for dissemination in space (DIS) and dissemination in time (DIT) to be used to diagnose multiple sclerosis in patients who...
Ciccarelli, O., Wheeler-Kingshott, C.A., McLean, M.A., Cercignani, M., Wimpey, K., Miller, D.H., ...
There is a need to assess spinal cord involvement in multiple sclerosis with new imaging techniques in order to understand better the underlying pathology. We aimed to evaluate whether quantitative...
Exploring disability rating scale responsiveness II: Do more response options help? (2006)
Cano, S.J., O’Connor, R.J., Thompson, A.J., Hobart, J.C.
The Barthel Index (BI) may underestimate disability change because its items have few response options. We examined whether a similar scale with more response options (Functional Independence...
CDIP-58 can measure the impact of botulinum toxin treatment in cervical dystonia (2006)
Cano, S.J., Hobart, J.C., Edwards, M., Fitzpatrick, R., Bhatia, K., Thompson, A.J., ...
We compared the responsiveness of the Cervical Dystonia Impact Profile (CDIP-58), Medical Outcome Study Short Form-Health Survey (SF-36), Functional Disability Questionnaire (FDQ), and Pain and...
Motor system activation after subcortical stroke depends on corticospinal system integrity (2006)
Ward, N.S., Newton, J.M., Swayne, O.B.C., Lee, L., Thompson, A.J., Greenwood, R.J., ...
Movement-related brain activation patterns after subcortical stroke are characterized by relative overactivations in cortical motor areas compared with controls. In patients able to perform a motor...
Hobart, J. C., Riazi, A., Thompson, A. J., Styles, I. M., Ingram, W., Vickery, P. J., ...
Spasticity is most commonly defined as an inappropriate, velocity dependent, increase in muscle tonic stretch reflexes, due to the amplified reactivity of motor segments to sensory input. It forms...
Ciccarelli, O., Behrens, T. E., Altmann, D. R., Orrell, R. W., Howard, R. S., Johansen-Berg, H., ...
The goal of probabilistic tractography is to obtain a connectivity index along a white matter pathway that reflects fibre organization and is sensitive to pathological abnormalities contributing to...
Ciccarelli, O., Behrens, T. E., Altmann, D. R., Orrell, R. W., Howard, R. S., Johansen-Berg, H., ...
The goal of probabilistic tractography is to obtain a connectivity index along a white matter pathway that reflects fibre organization and is sensitive to pathological abnormalities contributing to...
Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis (2005)
Trip, S.A., Schlottmann, P.G., Jones, S.J., Altmann, D.R., Garway-Heath, D.F., Thompson, A.J., ...
Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis relapse; therefore, noninvasive in vivo markers specific for axonal loss are needed. We used optic...
Johansen-Berg, H., Behrens, T.E.J., Ciccarelli, O., Thompson, A.J., Smith, S.M., Matthews, P.M., ...
Parcellation of the human thalamus based on cortical connectivity information inferred from non-invasive diffusion-weighted images identifies sub-regions that we have proposed correspond to nuclei....
A longitudinal study of cognition in primary progressive multiple sclerosis (2005)
Camp, S. J., Stevenson, V. L., Thompson, A. J., Ingle, G. T., Miller, D. H., Borras, C., ...
There are few longitudinal studies of cognition in patients with multiple sclerosis, and the results of these studies remain inconclusive. No serial neuropsychological data of an exclusively primary...
Fernando, K. T. M., Tozer, D. J., Miszkiel, K. A., Gordon, R. M., Swanton, J. K., Dalton, C. M., ...
In established multiple sclerosis, magnetization transfer ratio (MTR) histograms reveal abnormalities of normal-appearing white matter (NAWM) and grey matter (NAGM). The aim of this study was to...
A longitudinal study of cognition in primary progressive multiple sclerosis (2005)
Camp, S. J., Stevenson, V. L., Thompson, A. J., Ingle, G. T., Miller, D. H., Borras, C., ...
There are few longitudinal studies of cognition in patients with multiple sclerosis, and the results of these studies remain inconclusive. No serial neuropsychological data of an exclusively primary...
Fernando, K. T. M., Tozer, D. J., Miszkiel, K. A., Gordon, R. M., Swanton, J. K., Dalton, C. M., ...
In established multiple sclerosis, magnetization transfer ratio (MTR) histograms reveal abnormalities of normal-appearing white matter (NAWM) and grey matter (NAGM). The aim of this study was to...
Hobart, J. C., Riazi, A., Thompson, A. J., Styles, I. M., Ingram, W., Vickery, P. J., ...
Spasticity is most commonly defined as an inappropriate, velocity dependent, increase in muscle tonic stretch reflexes, due to the amplified reactivity of motor segments to sensory input. It forms...
Cano, S.J., Warner, T.T., Linacre, J.M., Bhatia, K.P., Thompson, A.J., Fitzpatrick, R., ...
Objectives: To develop a new rating scale for measuring the health impact of cervical dystonia (CD) that includes patients’ perceptions and complements existing observer dependent clinician rating...
Davies, G.R., Ramió-Torrentà, L., Hadjiprocopis, A., Chard, D.T., Griffin, C.M.B., Rashid, W., ...
Objectives: To establish whether magnetisation transfer ratio (MTR) histograms are sensitive to change in normal appearing grey matter (NAGM) in early relapsing-remitting multiple sclerosis (RRMS) in...
Rehabilitation of the cancer patient: experience in a neurological unit (2004)
Garrard, P., Farnham, C., Thompson, A.J., Playford, E.D.
We performed a retrospective review of all patients admitted to a neurological rehabilitation unit over a 5-year period to identify the benefits and problems associated with inpatient rehabilitation...
The influence of time after stroke on brain activations during a motor task (2004)
Ward, N.S., Brown, M.M., Thompson, A.J., Frackowiak, R.S.J.
fter stroke, the pattern of brain activation during performance of a motor task is related to outcome. Here, we compare this relationship in the early (10-14 days) and late (at least 3 months) phases...
Exploring rating scale responsiveness: does the total score reflect the sum of its parts? (2004)
O’Connor, R.J., Cano, S.J., Thompson, A.J., Hobart, J.C.
Evaluating rehabilitation requires rating scales that detect change. The authors examined Barthel Index (BI) data from 1,495 patients at a neurorehabilitation unit to determine whether total scale...
Dalton, C.M., Chard, D.T., Davies, G.R., Miszkiel, K.A., Altmann, D.R., Fernando, K., ...
While brain atrophy occurs early in the clinical course of multiple sclerosis, exactly how early, which tissues are affected and the rate at which early atrophy occurs are unclear. Regional brain...
Serial magnetization transfer imaging in acute optic neuritis (2004)
Hickman, S. J., Toosy, A. T., Jones, S. J., Altmann, D. R., Miszkiel, K. A., MacManus, D. G., ...
In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination. This...
Fernando, K. T. M., McLean, M. A., Chard, D. T., MacManus, D. G., Dalton, C. M., Miszkiel, K. A., ...
Normal-appearing white matter (NAWM) in established multiple sclerosis has been shown to be abnormal using a variety of magnetic resonance (MR) techniques, including proton MR spectroscopy (1H-MRS),...
Fernando, K. T. M., McLean, M. A., Chard, D. T., MacManus, D. G., Dalton, C. M., Miszkiel, K. A., ...
Normal‐appearing white matter (NAWM) in established multiple sclerosis has been shown to be abnormal using a variety of magnetic resonance (MR) techniques, including proton MR spectroscopy...
Serial magnetization transfer imaging in acute optic neuritis (2004)
Hickman, S. J., Toosy, A. T., Jones, S. J., Altmann, D. R., Miszkiel, K. A., MacManus, D. G., ...
In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination. This...
Serial magnetization transfer imaging in acute optic neuritis (2004)
Hickman, S. J., Toosy, A. T., Jones, S. J., Altmann, D. R., Miszkiel, K. A., MacManus, D. G., ...
In serial studies of multiple sclerosis lesions, reductions in magnetization transfer ratio (MTR) are thought to be due to demyelination and axonal loss, with later rises due to remyelination. This...
Fernando, K. T. M., McLean, M. A., Chard, D. T., MacManus, D. G., Dalton, C. M., Miszkiel, K. A., ...
Normal-appearing white matter (NAWM) in established multiple sclerosis has been shown to be abnormal using a variety of magnetic resonance (MR) techniques, including proton MR spectroscopy (1H-MRS),...
Neural correlates of motor recovery after stroke: a longitudinal fMRI study (2003)
Ward, N.S., Brown, M.M., Thompson, A.J., Frackowiak, R.S.J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the longitudinal relationship between recovery after...
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis (2003)
Pryce, G., Ahmed, Z., Hankey, D.J.R., Jackson, S.J., Croxford, J.L., Pocock, J.M., ...
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental...
Diffusion tractography based group mapping of major white-matter pathways in the human brain (2003)
Ciccarelli, O., Toosy, A.T., Parker, J.M., Wheeler-Kingshott, A.M., Barker, G.J., Miller, D.H., ...
Tractography uses diffusion tensor imaging data to trace white matter pathways in vivo within the brain. We have constructed group maps that represent three major white matter tracts—the anterior...
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging (2003)
Behrens, T.E.J., Johansen-Berg, H., Woolrich, M.W., Smith, S.M., Boulby, P.A., ...
Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has previously been used to define large...
Dubois, B.D., Keenan, E., Kapoor, R., Rudge, P., Thompson, A.J., ...
Background: The efficacy of interferon beta (IFN beta) is well established in relapsing-remitting multiple sclerosis (MS). However, the use of this drug in clinical practice is complex, especially...
Neural correlates of outcome after stroke: a cross-sectional fMRI study (2003)
Ward, N.S., Brown, M.M., Thompson, A.J., Frackowiak, R.S.J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to neuronal reorganization. Functional imaging studies investigating patients who have made a good...
Neural correlates of outcome after stroke: a cross-sectional fMRI study (2003)
Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to neuronal reorganization. Functional imaging studies investigating patients who have made a good...
Neural correlates of motor recovery after stroke: a longitudinal fMRI study (2003)
Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the longitudinal relationship between recovery after...
Primary progressive multiple sclerosis: a 5-year clinical and MR study (2003)
Ingle, G. T., Stevenson, V. L., Miller, D. H., Thompson, A. J.
Longitudinal imaging studies of primary progressive multiple sclerosis (PPMS) have shown significant changes in MR measures over 1 to 2 years. Correlation with clinical change over the same period...
Neural correlates of motor recovery after stroke: a longitudinal fMRI study (2003)
Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the longitudinal relationship between recovery after...
Primary progressive multiple sclerosis: a 5-year clinical and MR study (2003)
Ingle, G. T., Stevenson, V. L., Miller, D. H., Thompson, A. J.
Longitudinal imaging studies of primary progressive multiple sclerosis (PPMS) have shown significant changes in MR measures over 1 to 2 years. Correlation with clinical change over the same period...
Neural correlates of outcome after stroke: a cross-sectional fMRI study (2003)
Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to neuronal reorganization. Functional imaging studies investigating patients who have made a good...
Neural correlates of motor recovery after stroke: a longitudinal fMRI study (2003)
Ward, N. S., Brown, M. M., Thompson, A. J., Frackowiak, R. S. J.
Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the longitudinal relationship between recovery after...
Primary progressive multiple sclerosis: a 5-year clinical and MR study (2003)
Ingle, G. T., Stevenson, V. L., Miller, D. H., Thompson, A. J.
Longitudinal imaging studies of primary progressive multiple sclerosis (PPMS) have shown significant changes in MR measures over 1 to 2 years. Correlation with clinical change over the same period...
Chard, D.T., Griffin, C.M., McLean, M.A., Kapeller, P., Kapoor, R., Thompson, A.J., ...
While much work has concentrated on focal white matter (WM) lesions in multiple sclerosis, there is growing evidence to suggest that normal-appearing WM (NAWM) and grey matter (GM) are also involved...
Garrard, P., Bradshaw, D., Jager, H.R., Thompson, A.J., Losseff, N., Playford, D.
Cognitive dysfunction adversely influences long term outcome after cerebral insult, but the potential for brain stem lesions to produce cognitive as well as physical impairments is not widely...
Dalton, C.M., Brex, P.A., Miszkiel, K.A., Hickman, S.J., MacManus, D.G., Plant, G.T., ...
Traditionally, multiple sclerosis (MS) has been diagnosed on the basis of clinical evidence of dissemination in time and space. Previously, it could not be diagnosed in patients with single clinical...
Edwards, S.G.M., Playford, E.D., Hobart, J.C., Thompson, A.J.
Rehabilitation aims to reduce the impact of disease, within the limitations imposed by available resources and the underlying disease. Measuring rehabilitation is difficult. Rating scales of...
Shortening inpatient stay for stroke (2002)
Edwards, S.G.M., Thompson, A.J., Losseff, N., Playford, E.D.
Patients who have had a stroke benefit from organised inpatient care in a stroke unit,1 although the optimum model for care has yet to be determined. The key feature of stroke care seems to be...
Brain atrophy in clinically early relapsing-remitting multiple sclerosis (2002)
Chard, D.T., Griffin, C.M., Parker, G.J.M., Kapoor, R., Thompson, A.J., Miller, D.H.
Brain atrophy measured by MRI is a potentially useful tool for monitoring disease progression in multiple sclerosis. The location, extent and mechanisms of brain atrophy in early disease are not well...
A longitudinal study of abnormalities on MRI and disability from multiple sclerosis (2002)
Brex, P.A., Ciccarelli, O., O'Riordan, J.I., Sailer, M., Thompson, A.J., Miller, D.H.
Background: In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, such as optic neuritis or brain-stem or spinal cord syndromes, the presence of lesions as...
Froelicher,V. F., Yanowitz,F., Thompson,A. J., Lancaster,M. C.
Coronary heart disease (CHD) has reached epidemic proportions in all developed countries; it accounts for over 1,000,000 deaths in the United States each year, which is more than all other diseases...
Chard, D. T., Griffin, C. M., McLean, M. A., Kapeller, P., Kapoor, R., Thompson, A. J., ...
While much work has concentrated on focal white matter (WM) lesions in multiple sclerosis, there is growing evidence to suggest that normal‐appearing WM (NAWM) and grey matter (GM) are also...
Brain atrophy in clinically early relapsing-remitting multiple sclerosis (2002)
Chard, D. T., Griffin, C. M., Parker, G. J. M., Kapoor, R., Thompson, A. J., Miller, D. H.
Brain atrophy measured by MRI is a potentially useful tool for monitoring disease progression in multiple sclerosis. The location, extent and mechanisms of brain atrophy in early disease are not well...
Evidence-based measurement: which disability scale for neurologic rehabilitation? (2001)
Hobart, J.C., Lamping, D.L., Freeman, J.A., Langdon, D.W., McLellan, D.L., Greenwood, R.J., ...
Objective: To compare the 10-item Barthel Index (BI), 18-item Functional Independence Measure (FIM), and 30-item Functional Independence Measure + Functional Assessment Measure (FIM+FAM) as measures...
Barkhof, F., Filippi, M., Yousry, T., Miller, D.H., Hahn, D., ...
Recently, the clinical efficacy of interferon ß-1b (IFNß-1b) was demonstrated for secondary progressive (SP) multiple sclerosis in a European multicentre study. We evaluated the effect of IFNß-1b...
Ciccarelli, O., Werring, D.J., Wheeler–Kingshott, C.A.M., Barker, G.J., Parker, G.J.M., Thompson, A.J., ...
Objective: To quantitatively investigate water diffusion changes in normal-appearing white matter (NAWM) and gray matter in patients with MS, and to evaluate whether these changes are correlated with...
Thesis (MD)--Queen's University of Belfast, 2001.
Willison, H. J., O'Leary, C. P., Veitch, J., Blumhardt, L. D., Busby, M., Donaghy, M., ...
The clinical and laboratory phenotype of a paraproteinaemic neuropathy syndrome termed chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies is described in a series of 18 cases....
Relationship between feeding practices and weaning diarrhoea in Northeast Thailand (2000)
Cao, X., Rawalai, K., Thompson, A. J., Hartel, G. F., Thompson, S. J., Paterson, J. H., ...
Kersten, P., McLellan, D.L., Gross-Paju, K., Grigoriadis, N., Bencivenga, R., Beneton, C., ...
Objective : To develop an international services and needs assessment instrument (SUN) for people with multiple sclerosis and their carers and to pilot this in different countries of the European...
Relationship between feeding practices and weaning diarrhoea in Northeast Thailand (2000)
Cao, X., Rawalai, K., Thompson, A. J., Hartel, G. F., Thompson, S. J., Paterson, J. H., ...
Molyneux, P. D., Kappos, L., Polman, C., Pozzilli, C., Barkhof, F., Filippi, M., ...
The recently completed European trial of interferon beta-1b (IFNβ-1b) in patients with secondary progressive multiple sclerosis (SP multiple sclerosis) has given an opportunity to assess the impact...
Werring, D. J., Brassat, D., Droogan, A. G., Clark, C. A., Symms, M. R., Barker, G. J, ...
The idea that the initiating event in the formation of all new multiple sclerosis lesions is a focal blood–brain barrier (BBB) leakage associated with perivascular inflammation has been challenged...
Camp, S. J., Stevenson, V. L., Thompson, A. J., Miller, D. H., Borras, C., Auriacombe, S., ...
The relative rarity of primary progressive (PP) and transitional progressive (TP) multiple sclerosis has meant that little documentation of cognitive function in such patients is currently available....
Basic Organization of the Cardiovascular Laboratory (1998)
The purpose of this report is to help the cardiologist or radiologist organize and manage a cardiovascular laboratory and train the personnel to provide effective support. The physician must be able...
Davie, C. A., Barker, G. J., Webb, S., Tofts, P. S., Thompson, A. J., Harding, A. E., ...
A consistent error has been discovered in the calculation of cerebellar volumes in the three patient groups and in the control group. The calculated cerebellar volumes should have been multiplied by...
Losseff, N. A., Webb, S. L., O'Riordan, J. I., Page, R., Wang, L., Barker, G. J., ...
Recent MRI studies in multiple sclerosis have highlighted the potential importance of spinal cord atrophy (implicating axonal loss) in the development of disability. However, the techniques applied...
Spinal MRI in patients with suspected multiple sclerosis and negative brain MRI (1996)
Thorpe, J. W., Kidd, D., Moseley, I. F., Thompson, A. J., MacManus, D. G., Compston, D. A. S., ...
Although MRI detects the while lesions of multiple sclerosis within the brain with high sensitivity a minority of patients have normal brain MRL. We describe 20 patients, selected from over 170 who...
Davie, C. A., Barker, G. J., Webb, S., Tofts, P. S., Thompson, A. J., Harding, A. E., ...
Proton magnetic resonance spectroscopy (MRS) and MRI were carried out in II patients with multiple sclerosis who had clinical evidence of severe cerebellar involvement, 11 multiple sclerosis...
Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis (1995)
Filippi, M., Horsfield, M. A., Tofts, P. S., Barkhof, F., Thompson, A. J., Miller, D. H.
In recent years, several segmentation techniques have been developed to quantify brain MRI lesion load in multiple sclerosis and are now being used increasingly for both evaluating the natural...
Zoukos, Y., Kidd, D., Woodroofe, M. N., Kendall, B. E., Thompson, A. J., Cuzner, M. L.
Enhanced expression of β-adrenoceptor densities on peripheral blood mononuclear cells (PBMCs) in progressive multiple sclerosis patients has been observed in a number of independent studies. A link...
A comparison of the pathology of primary and secondary progressive multiple sclerosis (1994)
Revesz, T., Kidd, D., Thompson, A. J., Barnard, R. O., McDonald, W. I.
The dynamics of primary progressive multiple sclerosis differ from those of the more common secondary progressive form. The observation by MRI that the frequency of enhancement with gadolinium-DTPA,...
RADIOLOGICAL EROSIONS IN FROZEN SHOULDER (1990)
MORRIS, I. M., MATTINGLY, P. C., THOMPSON, A. J.
Erosions of the humeral head can occur in the frozen shoulder, with or without other radiological features. True erosions need to be distinguished from radiographic projectional artefacts. The...
KERMODE, A. G., THOMPSON, A. J., TOFTS, P., MACMANUS, D. G., KENDALL, B. E., KINGSLEY, D. P. E., ...
From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA...
Double strand break-induced recombination in Chlamydomonas reinhardtii chloroplasts.
Dürrenberger, F, Thompson, A J, Herrin, D L, Rochaix, J D
The mechanisms of chloroplast recombination are largely unknown. Using the chloroplast-encoded homing endonuclease I-CreI from Chlamydomonas reinhardtii, an experimental system is described that...
Self-splicing of the Chlamydomonas chloroplast psbA introns.
Herrin, D L, Bao, Y, Thompson, A J, Chen, Y F
We used alpha-32P-GTP labeling of total RNA preparations to identify self-splicing group I introns in Chlamydomonas. Several RNAs become labeled with alpha-32P-GTP, a subset of which is not seen with...
The group I intron from the chloroplast rRNA large subunit of Chlamydomonas reinhardtii (Cr.LSU) undergoes autocatalytic splicing in vitro. Cr.LSU displays a range of reactions typical of other group...
Cheesman, M R, Ankel-Fuchs, D, Thauer, R K, Thompson, A J
Cofactor 430 of methyl-coenzyme M reductase from Methanobacterium thermoautotrophicum was studied in both the extracted form in aqueous solution and protein-bound by using low-temperature...
Painful extremities and neurological disorder in essential thrombocythaemia.
Martin, E A, Lavin, P J, Thompson, A J
Six of 20 patients with essential thrombocythaemia had neurological features and 8 had peripheral vascular symptoms. Four had cerebrovascular ischaemia or stroke and 3 had gangrene. Pain in the...
Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study.
Thompson, A J, Kermode, A G, MacManus, D G, Kendall, B E, Kingsley, D P, Moseley, I F, ...
OBJECTIVE--To compare the abnormalities shown by magnetic resonance imaging of the brain in three clinically distinct groups of patients with multiple sclerosis, and to correlate the extent of...
Double strand break-induced recombination in Chlamydomonas reinhardtii chloroplasts.
Dürrenberger, F, Thompson, A J, Herrin, D L, Rochaix, J D
The mechanisms of chloroplast recombination are largely unknown. Using the chloroplast-encoded homing endonuclease I-CreI from Chlamydomonas reinhardtii, an experimental system is described that...
Self-splicing of the Chlamydomonas chloroplast psbA introns.
Herrin, D L, Bao, Y, Thompson, A J, Chen, Y F
We used alpha-32P-GTP labeling of total RNA preparations to identify self-splicing group I introns in Chlamydomonas. Several RNAs become labeled with alpha-32P-GTP, a subset of which is not seen with...
The group I intron from the chloroplast rRNA large subunit of Chlamydomonas reinhardtii (Cr.LSU) undergoes autocatalytic splicing in vitro. Cr.LSU displays a range of reactions typical of other group...
Cheesman, M R, Ankel-Fuchs, D, Thauer, R K, Thompson, A J
Cofactor 430 of methyl-coenzyme M reductase from Methanobacterium thermoautotrophicum was studied in both the extracted form in aqueous solution and protein-bound by using low-temperature...
Painful extremities and neurological disorder in essential thrombocythaemia.
Martin, E A, Lavin, P J, Thompson, A J
Six of 20 patients with essential thrombocythaemia had neurological features and 8 had peripheral vascular symptoms. Four had cerebrovascular ischaemia or stroke and 3 had gangrene. Pain in the...
Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study.
Thompson, A J, Kermode, A G, MacManus, D G, Kendall, B E, Kingsley, D P, Moseley, I F, ...
OBJECTIVE--To compare the abnormalities shown by magnetic resonance imaging of the brain in three clinically distinct groups of patients with multiple sclerosis, and to correlate the extent of...
Nuclear magnetic resonance monitoring of treatment and prediction of outcome in multiple sclerosis.
Magnetic resonance (MR) techniques provide an objective, sensitive and quantitative assessment of the evolving pathology in multiple sclerosis. There is an increasing definition of the pathological...
Unbinding Pathways of an Agonist and an Antagonist from the 5-HT3 Receptor
Thompson, A. J., Chan, S. L., Lummis, S. C. R.
The binding sites of 5-HT3 and other Cys-loop receptors have been extensively studied, but there are no data on the entry and exit routes of ligands for these sites. Here we have used molecular...
Kappa light chain glomerulosclerosis in multiple myeloma.
Seymour, A. E., Thompson, A. J., Smith, P. S., Woodroffe, A. J., Clarkson, A. R.
Kappa light chains were demonstrated by immunofluorescence microscopy in the renal basement membranes of 6 of 10 patients with multiple myeloma subjected to kidney biopsy. Nodular glomerulosclerosis...
international agreements ; free trade
Trade Liberalization and Stock Prices:Evidence from the Canada-United States Free Trade Agreement.
free trade ; international agreements
Visual evoked potentials in phenylketonuria: association with brain MRI, dietary state, and IQ.
Jones, S J, Turano, G, Kriss, A, Shawkat, F, Kendall, B, Thompson, A J
At separate institutions, pattern reversal visual evoked potentials (VEPs) were recorded in children and older patients with phenylketonuria and compared with MRI of the brain. In nine patients aged...
MRI dynamics of brain and spinal cord in progressive multiple sclerosis.
Kidd, D, Thorpe, J W, Kendall, B E, Barker, G J, Miller, D H, McDonald, W I, ...
OBJECTIVE--To assess the usefulness of serial cord MRI in patients with progressive multiple sclerosis. METHODS--Monthly MRI of the brain and spinal cord with and without gadolinium enhancement was...
Giovannoni, G, Thorpe, J W, Kidd, D, Kendall, B E, Moseley, I F, Thompson, A J, ...
OBJECTIVE--To determine whether concentrations of soluble E-selectin (sE-selectin), an immunological marker of endothelial activation, were correlated with gadolinium-DPTA enhancement on MRI in...
MRI of thoracic cord in tropical spastic paraparesis.
Kermode, A G, Rudge, P, Thompson, A J, Du Boulay, E P, McDonald, W I
Destructive lesions in demyelinating disease.
Youl, B D, Kermode, A G, Thompson, A J, Révész, T, Scaravilli, F, Barnard, R O, ...
Three cases are presented in which clinical and radiological features suggested the diagnosis of glioma but surgical biopsy revealed a demyelinating process, with tissue destruction and cyst...
EDMUS, a European database for multiple sclerosis.
Confavreux, C, Compston, D A, Hommes, O R, McDonald, W I, Thompson, A J
EDMUS is a minimal descriptive record developed for research purposes to document clinical and laboratory data in patients with multiple sclerosis (MS). It has been designed by a committee of the...
Miller, D H, Barkhof, F, Berry, I, Kappos, L, Scotti, G, Thompson, A J
Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important...
Biochemical changes within a multiple sclerosis plaque in vivo.
Cadoux-Hudson, T A, Kermode, A, Rajagopalan, B, Taylor, D, Thompson, A J, Ormerod, I E, ...
Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing a large multiple sclerosis (MS) lesion. Reduced levels of phosphocreatine (PCr) relative to adenosine...
Painful intraorbital meningiomas.
Wroe, S J, Thompson, A J, McDonald, W I
Three cases are reported of meningioma involving the orbital apex presenting with either progressive or episodic retroocular pain. In two cases pain was steroid responsive and in one of these...
Miller, D H, Thompson, A J, Morrissey, S P, MacManus, D G, Moore, S G, Kendall, B E, ...
The integrity of the blood-brain barrier (BBB) in multiple sclerosis (MS) was monitored by serial gadolinium-(Gd)-DTPA enhanced MRI during and after the treatment of acute relapses with a three day...
Seizures due to multiple sclerosis: seven patients with MRI correlations.
Thompson, A J, Kermode, A G, Moseley, I F, MacManus, D G, McDonald, W I
The MRI data of seven patients with clinically definite multiple sclerosis who developed epileptic seizures are presented. Six of these cases demonstrated new or enhancing lesions. Cerebral biopsy in...
Thompson, A J, Hutchinson, M, Martin, E A, Mansfield, M, Whelan, A, Feighery, C
CSF immunoglobulins were examined in 103 patients with clinically definite multiple sclerosis, 106 patients with either suspected or progressive possible multiple sclerosis and 72 patients with other...
Thompson, A J, Brazil, J, Martin, E A, Hutchinson, M, Whelan, C A, Feighery, C
This study demonstrates a significant reduction in the number of both total T cells and suppressor T cells identified by monoclonal antibodies in multiple sclerosis patients in acute relapse but not...
Thompson, A J, Brazil, J, Whelan, C A, Martin, E A, Hutchinson, M, Feighery, C
A serial study of peripheral blood T lymphocytes in 27 patients with clinically definite multiple sclerosis and 11 healthy controls was carried out over a 12 month period. This showed that contrary...
Ingram, D A, Thompson, A J, Swash, M
Magnetic stimulation of the brain and spinal column was used to assess conduction in the descending central motor pathways controlling arm and leg muscles of 20 patients with multiple sclerosis, and...
Koudriavtseva, T, Thompson, A J, Fiorelli, M, Gasperini, C, Bastianello, S, Bozzao, A, ...
The aim of the study was to evaluate the predictive power of baseline gadolinium (Gd) enhanced MRI in relation to subsequent clinical and MRI activity. Sixty eight patients with clinically definite...
Manji, H, Connolly, S, McAllister, R, Valentine, A R, Kendall, B E, Fell, M, ...
Seventy-six homosexual or bisexual men underwent two cranial MRI studies at a mean interval of 13 months; 23 were HIV seronegative, 41 seropositive but asymptomatic (Center for Disease Control (CDC)...
Kidd, D, Thompson, A J, Kendall, B E, Miller, D H, McDonald, W I
Data from two serial studies comparing the MRI activity of two groups of 11 patients, one with early relapsing-remitting (mean disease duration 3.5 years), the other benign (mean disease duration 22...
Lai, M, Hodgson, T, Gawne-Cain, M, Webb, S, MacManus, D, McDonald, W I, ...
Long TR and gadolinium enhanced spin echo brain MRI was performed weekly for three months in three patients with relapsing-remitting or secondary progressive multiple sclerosis. During the study, 38...
Clinical, CSF, and MRI findings in Devic's neuromyelitis optica.
O'Riordan, J I, Gallagher, H L, Thompson, A J, Howard, R S, Kingsley, D P, Thompson, E J, ...
OBJECTIVES: Since Devic's original description of neuromyelitis optica in 1894 there has been much debate regarding its aetiology. A specific cause has been identified in a minority of cases but in...
international agreements ; free trade
Trade Liberalization and Stock Prices:Evidence from the Canada-United States Free Trade Agreement.
free trade ; international agreements
Dividend Taxation and Equity Value: A Note on the Canadian Tax Changes of 1986
McKenzie, K.J., Thompson, A.J.
taxation
Thompson, A. J., Mulholland, H. C.
There is a recognised association between major gastrointestinal (GI) malformations and congenital heart disease (CHD). A retrospective study over 10 years involving 240 infants born with...
Divided Taxation and Equity Value: A Note on the Canadian Tax Changes of 1986.
McKenzie, K.J., Thompson, A.J.
tax policy
Increasing cord atrophy in early relapsing‐remitting multiple sclerosis: a 3 year study
Rashid, W, Davies, G R, Chard, D T, Griffin, C M, Altmann, D R, Gordon, R, ...
Antimalarial drugs inhibit human 5-HT3 and GABAA but not GABAC receptors
Background and purpose: Antimalarial compounds have been previously shown to inhibit rodent nicotinic acetylcholine (nACh) and 5-HT3 receptors. Here, we extend these studies to include human 5-HT3A,...
Modification of MRI criteria for multiple sclerosis in patients with clinically isolated syndromes
Swanton, J K, Fernando, K, Dalton, C M, Miszkiel, K A, Thompson, A J, Plant, G T, ...
Quantification of optic nerve head topography in optic neuritis: a pilot study
Trip, S A, Schlottmann, P G, Jones, S J, Garway‐Heath, D F, Thompson, A J, Plant, G T, ...
Swanton, J K, Fernando, K, Dalton, C M, Miszkiel, K A, Thompson, A J, Plant, G T, ...
The link between optic neuritis and multiple sclerosis is well established, as is the increased risk of conversion to multiple sclerosis, with lesions seen at presentation on the magnetic resonance...
Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis
Bieniek, M, Altmann, D R, Davies, G R, Ingle, G T, Rashid, W, Sastre‐Garriga, J, ...
Immunofluorescent detection of hormone receptors in cutaneous melanocytic tumours.
Thompson, A. J., Cook, M. G., Gill, P. G.
Immunofluorescent assessment of hormone receptors in melanocytic tumours is quite feasible without loss of diagnostic material, in contrast to the impracticability of quantitative biochemical assays....