A. J. Veerman

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment (2004)

Holleman, A., Cheng, C., Pui, C.H., Evans, W.E., Relling, M.V., Pieters, R., ...

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of...

Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia (1994)

Dong, F., Hoefsloot, L.H., Schelen, A.M., Broeders, C.A., Meijer, Y., Veerman, A.J., ...

Severe congenital neutropenia (Kostmann syndrome) is characterized by profound absolute neutropenia and a maturation arrest of marrow progenitor cells at the promyelocyte-myelocyte stage. Marrow...

Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.

Dong, F, Hoefsloot, L H, Schelen, A M, Broeders, C A, Meijer, Y, Veerman, A J, ...

Severe congenital neutropenia (Kostmann syndrome) is characterized by profound absolute neutropenia and a maturation arrest of marrow progenitor cells at the promyelocyte-myelocyte stage. Marrow...

Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.

Dong, F, Hoefsloot, L H, Schelen, A M, Broeders, C A, Meijer, Y, Veerman, A J, ...

Severe congenital neutropenia (Kostmann syndrome) is characterized by profound absolute neutropenia and a maturation arrest of marrow progenitor cells at the promyelocyte-myelocyte stage. Marrow...

Diagnosis of Wiskott-Aldrich syndrome by analysis of the X chromosome inactivation patterns in maternal leucocyte populations using the hypervariable DXS255 locus.

Hendriks, R W, De Weers, M, Mensink, R G, Kraakman, M E, Mollee-Versteegde, I F, Veerman, A J, ...

The Wiskott-Aldrich syndrome (WAS) is characterized by severe recurrent infections, petachiae and chronic eczema. The syndrome involves differentiation disorders in several haematopoietic cell...

Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia.

Pieters, R., Hongo, T., Loonen, A. H., Huismans, D. R., Broxterman, H. J., Hählen, K., ...

Although cellular drug resistance is considered to be an important cause of the poor prognosis of children with relapsed acute lymphoblastic leukaemia (ALL), the knowledge of drug resistance in these...

In vitro drug sensitivity of normal peripheral blood lymphocytes and childhood leukaemic cells from bone marrow and peripheral blood.

Kaspers, G. J., Pieters, R., Van Zantwijk, C. H., De Laat, P. A., De Waal, F. C., Van Wering, E. R., ...

In vitro drug sensitivity of leukaemic cells might be influenced by the contamination of such a sample with non-malignant cells and the sample source. To study this, sensitivity of normal peripheral...

Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assay.

Kaspers, G. J., Veerman, A. J., Pieters, R., Broekema, G. J., Huismans, D. R., Kazemier, K. M., ...

The methyl-thiazol-tetrazolium (MTT) assay is a drug resistance assay which cannot discriminate between malignant and non-malignant cells. We previously reported that samples with > or = 80%...

In vitro anthracycline cross-resistance pattern in childhood acute lymphoblastic leukaemia.

Klumper, E., Pieters, R., Den Boer, M. L., Huismans, D. R., Loonen, A. H., Veerman, A. J.

Daunorubicin (DNR) is a major front-line drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Previously, we showed that in vitro resistance to DNR at diagnosis is related to a...

Comparison of the rapid automated MTT-assay with a dye exclusion assay for chemosensitivity testing in childhood leukaemia.

Pieters, R., Huismans, D. R., Leyva, A., Veerman, A. J.