From zebra to starlings, herring and even tadpoles, many creatures move in an organized group. The emergent behaviour arises from simple underlying movement rules, but the evolutionary pressure which...
Mutation of albedo and growth response produces oscillations in a spatial Daisyworld (2006)
Wood, A.J., Ackland, G.J., Lenton, T.M.
We extended a two-dimensional cellular automaton (CA) Daisyworld to include mutation of optimal growth temperature as well as mutation of albedo. Thus, the organisms (daisies) can adapt to prevailing...
Wetting effects at a grain boundary (2004)
Abraham, D.B., Mustonen, V., Wood, A.J.
We consider a tier of weakened bonds along the center line of a two-dimensional Ising ferromagnet strip as a model of a grain boundary. When an interface traverses such a strip at an angle, whether...
Wedge covariance for two-dimensional filling and wetting (2002)
Parry, A.O., Greenall, M.J., Wood, A.J.
A comprehensive theory of interfacial fluctuation effects occurring at two-dimensional wedge (corner) filling transitions in pure (thermal disorder) and impure (random bond disorder) systems is...
Universal phase boundary shifts for corner wetting and filling (2001)
Parry, A. O., Wood, A. J., Carlon, E., Drzewiński, A.
The phase boundaries for corner wetting (filling) in square and diagonal lattice Ising models are exactly determined and show a universal shift relative to wetting near the bulk criticality. More...
Wedge covariance for 2D filling and wetting (2001)
Parry, A. O., Greenall, M. J., Wood, A. J.
A comprehensive theory of interfacial fluctuation effects occurring at 2D wedge (corner) filling transitions in pure (thermal disorder) and impure (random bond-disorder) systems is presented. Scaling...
Wedge filling, cone filling and the strong-fluctuation regime (2001)
Parry, A.O., Wood, A.J., Rascón, C.
Interfacial fluctuation effects occurring at wedge- and cone-filling transitions are investigated and shown to exhibit very different characteristics. For both geometries we argue that the conditions...
Universal phase boundary shifts for corner wetting and filling (2001)
Parry, A.O., Wood, A.J., Carlon, E., Drzewiński, A.
The phase boundaries for corner wetting (filling) in square and diagonal lattice Ising models are exactly determined and show a universal shift relative to wetting near the bulk criticality. More...
Wedge filling, cone filling and the strong fluctuation regime (2000)
Parry, A. O., Wood, A. J., Rascon, C.
Interfacial fluctuation effects occuring at wedge and cone filling transitions are investigated and shown to exhibit very different characteristics. For both geometries we show how the conditions for...
Universality for 2D Wedge Wetting (1999)
Parry, A. O., Rascon, C., Wood, A. J.
We study 2D wedge wetting using a continuum interfacial Hamiltonian model which is solved by transfer-matrix methods. For arbitrary binding potentials, we are able to exactly calculate the wedge...
Critical Effects at 3D Wedge-Wetting (1999)
Parry, A. O., Rascon, C., Wood, A. J.
We show that continuous filling or wedge-wetting transitions are possible in 3D wedge-geometries made from (angled) substrates exhibiting first-order wetting transitions and develop a comprehensive...
Postlethwaite, R. J., Eminson, D. M., Reynolds, J. M., Wood, A. J., Hollis, S.
Growth and psychological functioning were studied in 30 patients with renal failure over a two year period following the offer of growth hormone treatment for significant short stature. Parents'...
USE OF ESMOLOL IN THE POSTBYPASS MANAGEMENT OF HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY (1993)
OOI, L. G., O'SHEA, P. J., WOOD, A. J.
In patients suffering from hypertrophic obstructive cardiomyopathy (HOCM), any catecholamine release during anaesthesia may aggravate the severity of the outflow tract obstruction and compromise...
Near-isogenic lines of maize differing for glycinebetaine.
Yang, W J, Nadolska-Orczyk, A, Wood, K V, Hahn, D T, Rich, P J, Wood, A J, ...
A series of near-isogenic glycinebetaine-containing and -deficient F8 pairs of Zea mays L. (maize) lines were developed. The pairs of lines differ for alternative alleles of a single locus; the...
Betaine aldehyde dehydrogenase in sorghum.
Wood, A J, Saneoka, H, Rhodes, D, Joly, R J, Goldsbrough, P B
The ability to synthesize and accumulate glycine betaine is wide-spread among angiosperms and is thought to contribute to salt and drought tolerance. In plants glycine betaine is synthesized by the...
Stein, C M, Nelson, R, Deegan, R, He, H, Wood, M, Wood, A J
Impaired beta adrenoceptor-mediated vasodilation associated with enhanced sympathetic activity has been reported in established hypertension. We examined whether altered beta adrenoceptor-mediated...
Murray, K T, Reilly, C, Koshakji, R P, Roden, D M, Lineberry, M D, Wood, A J, ...
To investigate the mechanisms of ventricular arrhythmia suppression by propranolol, we determined the antiarrhythmic efficacy of d-propranolol in 10 patients with frequent ventricular ectopic...
Absence of prolactin gene expression in colorectal cancer.
Wood, A J, Thomas, C M, Baumforth, K R, Flavell, J R, Scott, K W, Grace, R H, ...
AIMS: Previous studies documenting hyperprolactinaemia in patients with colorectal cancer have suggested that the tumour is the source of hormone production. The aim of this study was to determine...
Leukocyte beta-receptor alterations in hypertensive subjects.
Feldman, R D, Limbird, L E, Nadeau, J, Robertson, D, Wood, A J
It has been suggested that beta-adrenergic responsiveness is reduced in hypertension. To evaluate a possible alteration in human beta-receptors that might account for diminished beta-adrenergic...
Proceedings: Gaucher's disease with biclonal gammopathy.
MacDonald, M, McCathie, M, Faed, M J, Pringle, R, Goodall, H B, Beck, J S, ...
Kim, R B, Fromm, M F, Wandel, C, Leake, B, Wood, A J, Roden, D M, ...
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral absorption and variable tissue distribution, both of which are largely...
Feldman, R D, Limbird, L E, Nadeau, J, FitzGerald, G A, Robertson, D, Wood, A J
beta-Adrenergic receptors on human mononuclear leukocytes were assessed using [125I]iodohydroxybenzylpindolol binding. Subjects were studied supine and after being ambulatory, a maneuver that...
Further Studies on the Immobilization of Deer with Succinylcholine
Nordan, H. C., Wood, A. J., Cowan, I. McT.
Further studies are reported on the use of succinylcholine as an immobilizing agent for the deer (Odocoileus). The dosage required for complete immobilization was 0.06 mgms per kilogram body weight...
Near-isogenic lines of maize differing for glycinebetaine.
Yang, W J, Nadolska-Orczyk, A, Wood, K V, Hahn, D T, Rich, P J, Wood, A J, ...
A series of near-isogenic glycinebetaine-containing and -deficient F8 pairs of Zea mays L. (maize) lines were developed. The pairs of lines differ for alternative alleles of a single locus; the...
Betaine aldehyde dehydrogenase in sorghum.
Wood, A J, Saneoka, H, Rhodes, D, Joly, R J, Goldsbrough, P B
The ability to synthesize and accumulate glycine betaine is wide-spread among angiosperms and is thought to contribute to salt and drought tolerance. In plants glycine betaine is synthesized by the...
Stein, C M, Nelson, R, Deegan, R, He, H, Wood, M, Wood, A J
Impaired beta adrenoceptor-mediated vasodilation associated with enhanced sympathetic activity has been reported in established hypertension. We examined whether altered beta adrenoceptor-mediated...
Murray, K T, Reilly, C, Koshakji, R P, Roden, D M, Lineberry, M D, Wood, A J, ...
To investigate the mechanisms of ventricular arrhythmia suppression by propranolol, we determined the antiarrhythmic efficacy of d-propranolol in 10 patients with frequent ventricular ectopic...
Absence of prolactin gene expression in colorectal cancer.
Wood, A J, Thomas, C M, Baumforth, K R, Flavell, J R, Scott, K W, Grace, R H, ...
AIMS: Previous studies documenting hyperprolactinaemia in patients with colorectal cancer have suggested that the tumour is the source of hormone production. The aim of this study was to determine...
Leukocyte beta-receptor alterations in hypertensive subjects.
Feldman, R D, Limbird, L E, Nadeau, J, Robertson, D, Wood, A J
It has been suggested that beta-adrenergic responsiveness is reduced in hypertension. To evaluate a possible alteration in human beta-receptors that might account for diminished beta-adrenergic...
Proceedings: Gaucher's disease with biclonal gammopathy.
MacDonald, M, McCathie, M, Faed, M J, Pringle, R, Goodall, H B, Beck, J S, ...
Kim, R B, Fromm, M F, Wandel, C, Leake, B, Wood, A J, Roden, D M, ...
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral absorption and variable tissue distribution, both of which are largely...
Feldman, R D, Limbird, L E, Nadeau, J, FitzGerald, G A, Robertson, D, Wood, A J
beta-Adrenergic receptors on human mononuclear leukocytes were assessed using [125I]iodohydroxybenzylpindolol binding. Subjects were studied supine and after being ambulatory, a maneuver that...
Further Studies on the Immobilization of Deer with Succinylcholine
Nordan, H. C., Wood, A. J., Cowan, I. McT.
Further studies are reported on the use of succinylcholine as an immobilizing agent for the deer (Odocoileus). The dosage required for complete immobilization was 0.06 mgms per kilogram body weight...
Dill, S, Payne-James, J J, Misiewicz, J J, Grimble, G K, McSwiggan, D, Pathak, K, ...
Sixty nine patients with non-ulcer dyspepsia have been studied with endoscopy, biopsy, quick urease (CLO) test, Helicobacter pylori culture, and the 13C-urea breath test before and after treatment...
The effect of oral salbutamol on cation transport measured in vivo in healthy volunteers.
Wood, A J, Brearley, C J, Aronson, J K, Grahame-Smith, D G
1. We have measured the effect of oral salbutamol on cation transport in vivo by studying the disposition of an oral load of rubidium chloride in healthy treated volunteers and in untreated matched...
Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin.
Zhou, H H, Anthony, L B, Wood, A J, Wilkinson, G R
Studies were performed in 13 healthy subjects to determine whether treatment with rifampicin results in induction of the metabolism of mephenytoin. Daily dosing with 600 mg rifampicin for 22 days...
A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism.
Funck-Brentano, C, Silberstein, D J, Roden, D M, Wood, A J, Woosley, R L
1. In order to determine whether the effects of d- or (+)-sotalol on heart rate are mediated by beta-adrenoceptor antagonism or might be due to other actions, we administered (+)-sotalol (400 mg...
Wood, A J, Aronson, J K, Bunch, C, Grahame-Smith, D G
1. We have given an oral load of lithium carbonate to healthy volunteers in order to investigate the transport of lithium across the erythrocyte membrane in vivo and the effects of known inhibitors...
Lack of effect of ageing on the stereochemical disposition of propranolol.
Zhou, H H, Whelan, E, Wood, A J
The elderly are more resistant to the effects of propranolol than the young. To determine whether the decreased sensitivity in the elderly could be due to stereoselective alteration in propranolol...
Antia, I J, Dorkins, C E, Wood, A J, Aronson, J K
1. We have measured [3H]-ouabain binding to lymphocyte membranes in eight healthy volunteers before and after they had taken lithium carbonate for 14 days in doses which maintained the serum lithium...
Elimination kinetics of labetalol in severe renal failure
Wood, A. J., Ferry, D. G., Bailey, R. R.
1 The pharmacokinetics of intravenously administered labetalol were studied in four patients with severe renal failure and in three normal subjects.
Feely, J, Nadeau, J, Wood, A J
In six healthy subjects a 250 g steak significantly increased the systemic clearance of indocyanine green. During a steady-state infusion of propranolol there was a rapid decrease (mean 35%) in blood...
Effect of inhibitors of prostaglandin synthesis on hepatic drug clearance.
The effect of inhibition of prostaglandin synthesis on the systemic clearance of indocyanine green and antipyrine was studied in seven subjects. Antipyrine clearance was not altered by indomethacin...
Induction of propranolol metabolism by rifampicin.
Herman, R J, Nakamura, K, Wilkinson, G R, Wood, A J
The effect of rifampicin on the blood concentration-time curve of propranolol at steady-state following oral administration of 120 mg every 8 h was investigated in six normal, young, male subjects....
Determinants of anticoagulant control in patients receiving warfarin.
O'Malley, K, Stevenson, I H, Ward, C A, Wood, A J, Crooks, J
1 A hospital-based drug information system has been used to assess the time for which patients treated with warfarin were outside the range of Thrombotest values 5-10% and 5-15% and to examine...
Direct measurement of propranolol bioavailability during accumulation to steady-state.
Wood, A J, Carr, K, Vestal, R E, Belcher, S, Wilkinson, G R, Shand, D G
1. A high performance liquid chromatographic method for the determination of propranolol in human plasma and blood has been developed and used to confirm that cumulation occurred during chronic oral...
Effect of heparin administration on plasma binding of benzodiazepines.
Desmond, P V, Roberts, R K, Wood, A J, Dunn, G D, Wilkinson, G R, Schenker, S
1 The effect of intravenous administration of 100 units of heparin on plasma of diazepam, chlordiazepoxide, oxazepam and lorazepam was examined in fourteen normal subjects and five patients with...
Propranolol disposition in renal failure.
Wood, A J, Vestal, R E, Spannuth, C L, Stone, W J, Wilkinson, G R, Shand, D G
1 Previous studies of propranolol disposition in renal failure have been conflicting. 2 Using simultaneous administration of [3H]-propranolol intravenously and unlabelled propranolol orally the...
Postlethwaite, R J, Reynolds, J M, Wood, A J, Evans, J H, Lewis, M A, Eminson, D M
Issues raised by the recruitment of children to trials of growth hormone treatment for short stature in chronic renal failure are reported. Information needs of parents and children are discussed,...
Short stature and chronic renal failure: what concerns children and parents?
Reynolds, J M, Wood, A J, Eminson, D M, Postlethwaite, R J
Multicentre trials are evaluating growth hormone treatment in short children (height > 2 SDs below mean) with chronic renal failure (CRF), on dialysis, or with a transplant. Thirty children and...
Intrathoracic extramediastinal cystic hygroma.
Pike, M G, Wood, A J, Corrin, B, Warner, J O
A case of intrathoracic, extramediastinal cystic hygroma presenting with pneumonia in a 6 year old boy is described.
Scriven, J. M., Taylor, L. E., Wood, A. J., Bell, P. R., Naylor, A. R., London, N. J.
This trial was undertaken to examine the safety and efficacy of four-layer compared with short stretch compression bandages for the treatment of venous leg ulcers within the confines of a...
Metastatic renal carcinoma presenting with profuse haemorrhage at cardiac surgery.
Wood, A. J., Wood, J. R., Corrin, B., Paneth, M.
A 62-year-old man undergoing coronary artery bypass grafting sustained profuse unexplained haemorrhage during sternal diathermy before sternotomy. Histology of tissue from the sternum suggested...