Antoniou, A.C., Spurdle, A.B., Sinilnikova, O.M., Healey, S., Pooley, K.A., Schmutzler, R.K., ...
Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families....
Godwin, A K, Meister, A, O'Dwyer, P J, Huang, C S, Hamilton, T C, Anderson, M E
Exposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that exhibited increasing degrees of drug resistance, which were closely correlated with increase of the...
Cheng, J Q, Godwin, A K, Bellacosa, A, Taguchi, T, Franke, T F, Hamilton, T C, ...
We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to...
Mutation detection using a novel plant endonuclease.
Oleykowski, C A, Bronson Mullins, C R, Godwin, A K, Yeung, A T
We have discovered a useful new reagent for mutation detection, a novel nuclease CEL I from celery. It is specific for DNA distortions and mismatches from pH 6 to 9. Incision is on the 3'-side of the...
Li, Y C, Seyama, T, Godwin, A K, Winokur, T S, Lebovitz, R M, Lieberman, M W
We studied the effects of a zinc-inducible metallothionein-ras fusion gene (MTrasT24) in cultured rat liver epithelial (RLE) cells on expression of two genes induced during liver carcinogenesis in...
Neuhausen, S L, Godwin, A K, Gershoni-Baruch, R, Schubert, E, Garber, J, Stoppa-Lyonnet, D, ...
Several BRCA2 mutations are found to occur in geographically diverse breast and ovarian cancer families. To investigate both mutation origin and mutation-specific phenotypes due to BRCA2, we...
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
Rebbeck, T R, Kantoff, P W, Krithivas, K, Neuhausen, S, Blackwood, M A, Godwin, A K, ...
Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing breast cancer. However, there is also substantial...
Godwin, A K, Meister, A, O'Dwyer, P J, Huang, C S, Hamilton, T C, Anderson, M E
Exposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that exhibited increasing degrees of drug resistance, which were closely correlated with increase of the...
Cheng, J Q, Godwin, A K, Bellacosa, A, Taguchi, T, Franke, T F, Hamilton, T C, ...
We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to...
Mutation detection using a novel plant endonuclease.
Oleykowski, C A, Bronson Mullins, C R, Godwin, A K, Yeung, A T
We have discovered a useful new reagent for mutation detection, a novel nuclease CEL I from celery. It is specific for DNA distortions and mismatches from pH 6 to 9. Incision is on the 3'-side of the...
Li, Y C, Seyama, T, Godwin, A K, Winokur, T S, Lebovitz, R M, Lieberman, M W
We studied the effects of a zinc-inducible metallothionein-ras fusion gene (MTrasT24) in cultured rat liver epithelial (RLE) cells on expression of two genes induced during liver carcinogenesis in...
Neuhausen, S L, Godwin, A K, Gershoni-Baruch, R, Schubert, E, Garber, J, Stoppa-Lyonnet, D, ...
Several BRCA2 mutations are found to occur in geographically diverse breast and ovarian cancer families. To investigate both mutation origin and mutation-specific phenotypes due to BRCA2, we...
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
Rebbeck, T R, Kantoff, P W, Krithivas, K, Neuhausen, S, Blackwood, M A, Godwin, A K, ...
Compared with the general population, women who have inherited a germline mutation in the BRCA1 gene have a greatly increased risk of developing breast cancer. However, there is also substantial...
Berman, D. B., Wagner-Costalas, J., Schultz, D. C., Lynch, H. T., Daly, M., Godwin, A. K.
We screened 163 women from breast-ovarian cancer-prone families, as well as 178 individuals affected with breast and/or ovarian cancer but unselected for family history, for germ-line mutations in...