Fountzilas, G., Zisiadis, A., Dafni, U., Konstantaras, C., Hatzitheoharis, G., Liaros, A., ...
Background: Randomized studies have shown that postoperative chemotherapy with or without radiation therapy (RT) improved local control and survival of patients with stages II or III rectal cancer....
High E(T) inclusive jet cross-sections in photoproduction at HERA (1998)
ZEUS Collaboration, Breitweg, J, Derrick, M, Krakauer, D, Magill, S, Mikunas, D, ...
Voutsinas, G., Kappas, A., Demopoulos, N.A., Catsoulacos, P.
The mutagenic activity of the new antitumour agent 3β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-N,N-bis(2-chloroethyl)aminophenoxyacetate (NSC 294859) was studied in the...
Tallysomycin-induced mitotic aneuploidy and point mutations in Aspergillus nidulans (1986)
Tallysomycin is an antibiotic compound structurally related to bleomycin, and like bleomycins and phleomycins also shows antitumour activity. We have investigated the genetic activity of tallysomycin...
Genotoxic activity of plant growth-regulating hormones in Aspergillus nidulans (1983)
Three plant growth-regulating hormones, indole-3-acetic acid (IAA), indole-3-butyric acid (IBA), and kinetin (6-furfuryl-aminopurine), were tested for their genetic activity in Asper-gillus nidulans...
Abraham, N G, Lavrovsky, Y, Schwartzman, M L, Stoltz, R A, Levere, R D, Gerritsen, M E, ...
Heme oxygenase (HO) is a stress protein and has been suggested to participate in defense mechanisms against agents that may induce oxidative injury such as metals, endotoxin, heme/hemoglobin, and...
Lavrovsky, Y, Schwartzman, M L, Levere, R D, Kappas, A, Abraham, N G
Heme oxygenase (HO) is the rate-limiting enzyme in heme catabolism and its activity is induced by many agents, including its substrate heme, heavy metals, UV radiation, and other injurious oxidant...
The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria.
Nakahashi, Y, Fujita, H, Taketani, S, Ishida, N, Kappas, A, Sassa, S
The molecular basis of an inherited defect of ferrochelatase in a patient with erythropoietic protoporphyria (EPP) was investigated. Ferrochelatase is the terminal enzyme in the heme biosynthetic...
Levere, R D, Gong, Y F, Kappas, A, Bucher, D J, Wormser, G P, Abraham, N G
The effects of heme alone and heme administered together with 3'-azido-3'-deoxythymidine (AZT) on human immunodeficiency virus replication in human peripheral blood lymphocytes and in the H9 cell...
Kappas, A., Georgopoulos, S. G.
Low concentrations of the antibiotic griseofulvin were found to cause increased frequencies of somatic segregation due to chromosome nondisjunction in a diploid strain of Aspergillus nidulans.
Regulation of food intake and body weight by cobalt porphyrins in animals.
Cobalt-substituted protoporphyrin administered subcutaneously to normal adult rats elicited prompt decreases in food intake and sustained decreases in body weight. Repetitive parenteral...
Tin(IV)-protoporphyrin (Sn-protoporphyrin) potently inhibits heme degradation to bile pigments in vitro and in vivo, a property that confers upon this synthetic compound the ability to suppress a...
Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b.
Ishida, N, Inuzuka, C, Tawaragi, Y, Sugita, O, Nakazato, H, Noguchi, T, ...
Kappas, A, Bradlow, H L, Bickers, D R, Alvares, A P
The hepatic enzymes that catalyze drug oxidations and the reductive metabolism of steroid hormones to 5alpha-derivatives are localized in membranes of the endoplasmic reticulum. Phenobarbital, which...
The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology.
An experimental method is described to deplete markedly in vivo the cytochrome P-450 content of liver for prolonged periods of time. The method uses the synthetic metalloporphyrin cobalt-heme (cobalt...
Thyroid hormone regulation of heme oxidation in the liver.
Smith, T J, Drummond, G S, Kourides, I A, Kappas, A
The effects of 3,5,3'-triiodothyronine (T3) on heme oxygenase (EC 1.14.99.3) activity and cytochrome P-450 content in liver were examined in thyroidectomized rats. T3, when administered for 5 days at...
The effects of various metalloporphyrins on hepatic heme oxygenase (EC 1.14.99.3) activity were examined in order to identify compounds that could inhibit heme degradation to bile pigment and might...
Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.
Fishman, J, Bradlow, H L, Schneider, J, Anderson, K E, Kappas, A
The oxidative metabolism of estradiol was studied in normal men and women by a radiometric procedure that provides information on the totality of the biotransformations concerned. The release of 3H...
Sassa, S, Zalar, G L, Poh-Fitzpatrick, M B, Anderson, K E, Kappas, A
In this paper we show that the ferrochelatase defect in erythropoietic protoporphyria (EPP) can readily be identified in mitogen-stimulated lymphocytes since such cells from patients with EPP...
Schneider, J, Sassa, S, Kappas, A
The oxidative metabolism of estradiol (the natural estrogen 2,3,5(10)-estratriene-3,17 beta-diol) at positions C-2 and C-16 was examined in primary cultures of chick embryo liver cells using...
Whetsell, W O, Sassa, S, Kappas, A
Well-myelinated cultures of mouse dorsal root ganglia incubated for 48 h with sigma-aminolevulinic acid (ALA) showed intense porphyrin fluorescence localized in myelin sheaths but not in axons or...
Sassa, S., Granick, S., Bickers, D. R., Bradlow, H. L., Kappas, A.
A new spectrofluorometric assay is described for quantitating uroporphyrinogen I synthase (EC 4.3.1.8) activity in volumes of human blood as small as 2 μl. By this sensitive assay the inheritance of...
Kappas, A, Simionatto, C S, Drummond, G S, Sassa, S, Anderson, K E
TinIV-protoporphyrin IX (Sn-protoporphyrin) potently inhibits heme degradation to bilirubin in vitro and in vivo, and it completely suppresses neonatal hyperbilirubinemia in experimental animals,...
Control of heme metabolism with synthetic metalloporphyrins.
Studies with synthetic metal-porphyrin complexes in which the central iron atom of heme is replaced by other elements indicate that those heme analogues that cannot be enzymatically degraded to bile...
Kappas, A, Drummond, G S, Sardana, M K
Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, the rate-limiting enzyme in heme degradation to bile pigment, and has been successfully utilized to suppress hyperbilirubinemia...
Sn(tin)-protoporphyrin, a potent competitive inhibitor of heme oxygenase, can suppress hyperbilirubinemia in animal neonates and significantly reduce plasma bilirubin levels in animals and man. To...
Simionatto, C S, Anderson, K E, Drummond, G S, Kappas, A
The synthetic heme analogue Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, the rate-limiting enzyme in heme degradation to bile pigment, and can entirely suppress...
Galbraith, R A, Drummond, G S, Kappas, A
The ability of Sn(tin)-protoporphyrin to inhibit the induction of hepatic delta-aminolevulinate (ALA) synthase by allylisopropyl acetamide (AIA) was examined in the adult rat. Doses of...
Fujita, H, Sassa, S, Toback, A C, Kappas, A
Hepatoerythropoietic porphyria (HEP) is due to a marked deficiency of uroporphyrinogen (URO) decarboxylase, a cytosolic enzyme in the heme biosynthetic pathway. Using a radioimmunoassay method, we...
A model of experimental postnatal hyperbilirubinemia in the rat has been developed utilizing the heme precursor delta-aminolevulinic acid (ALA) to produce jaundice during a selective time period...
Granick, S., Sassa, S., Granick, J. L., Levere, R. D., Kappas, A.
Three micromethods are described for the assay of enzymes or products of the heme biosynthetic pathway in blood. A fluorometric method for the assay of protoporphyrin may be applied to the rapid...
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.
Maines, M D, Janousĕk, V, Tomio, J M, Kappas, A
Cobalt has complex actions on the metabolism of heme in the liver. In this organ the metal potently induces heme oxygenase (EC 1.14.99.3), and decreases cellular heme and hemoprotein content. The...
Interactions between nutritional factors and drug biotransformations in man.
Alvares, A P, Anderson, K E, Conney, A H, Kappas, A
This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three normal volunteers...
The trace metals nickel and platinum, which are not substrates for ferrochelatase and thus do not form heme in biological systems, were found to act similaryl to cobalt, and heme itself, in...
Selenium was found to be a novel regulator of cellular heme methabolism in that the element induced both the mitochondrial enzyme delta-aminolevulinate synthase [succinyl-CoA:glycine...
Ishida, N, Fujita, H, Fukuda, Y, Noguchi, T, Doss, M, Kappas, A, ...
Cloning and expression of the defective genes for delta-aminolevulinate dehydratase (ALAD) from a patient with inherited ALAD deficiency porphyria (ADP) were carried out. Cloning of cDNAs for the...
Kappas, A, Anderson, K E, Conney, A H, Pantuck, E J, Fishman, J, Bradlow, H L
The in vivo biotransformations of drugs known to be metabolized by enzymes localized in the endoplasmic reticulum of liver can be greatly altered by diet in humans, as we have shown previously....
Mitani, K, Fujita, H, Fukuda, Y, Kappas, A, Sassa, S
The role of inorganic metals and metalloporphyrins in the induction of mRNAs for haem oxygenase and heat-shock protein 70 (hsp70), the two heat-shock proteins, was examined in human HepG2 and Hep3B...
delta-Aminolaevulinate (ALA) synthase, the rate-limiting enzyme in haem biosynthesis in the normal liver, was examined in human HepG2 hepatoma cells. Haemin, up to 100 microM, had no effect on ALA...
The effects of acute-phase inducers and dimethyl sulphoxide (Me2SO) on delta-aminolaevulinate (ALA) synthase in HepG2 cells were examined. Treatment of cells with Me2SO resulted in a significant...
Sassa, S, Sugita, O, Ohnuma, N, Imajo, S, Okumura, T, Noguchi, T, ...
Treatment of cultured chick-embryo liver cells with polychlorinated biphenyls (PCB) results in decreased uroporphyrinogen decarboxylase activity and increased uroporphyrin accumulation. In the...
Galbraith, R A, Sassa, S, Kappas, A
Exposure of cultured human hepatoma cells (Hep G2) to medium containing 2% (v/v) dimethyl sulphoxide resulted in an approximate doubling in the activity of delta-aminolaevulinate dehydratase, an...
De Verneuil, H, Sassa, S, Kappas, A
Treatment of cultured chick embryo hepatocytes with phenobarbital, polychlorinated biphenyl compounds and 2,3,7,8-tetrachlorodibenzo-p-dioxin resulted in increased delta-aminolaevulinate synthase and...
Drummond, G S, Rosenberg, D W, Kappas, A
The induction of hepatic haem oxygenase (EC 1.14.99.3) by a series of metals, organometals and metalloporphyrins was examined in vivo in the presence of compound SKF 525A, which is known to complex...
Rosenberg, D W, Drummond, G S, Cornish, H C, Kappas, A
The administration of organotin compounds to rats in single doses causes a significant and prolonged induction of haem oxygenase and a sustained decrease in haemoprotein content in the liver. The...
Metal ion interactions in the control of haem oxygenase induction in liver and kidney.
Mn2+ and Zn2+ exhibit a striking ability to block the induction by Sn2+ and Ni2+ of haem oxygenase (EC 1.14.99.3) in kidney. The blocking effects of Mn2+ and Zn2+ were found to be greatest on...
Sardana, M K, Sassa, S, Kappas, A
The responses of hepatic delta-aminolaevulinate synthase and microsomal haem oxygenase to inducers were examined in pregnant rats. 2-Allyl-2-isopropylacetamide-mediated induction of...
Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions.
Cobalt ions (Co2+) are potent inducers of haem oxygenase in liver and inhibit microsomal drug oxidation probably by depleting microsomal haem and cytochrome P-450. Complexing of Co2+ ions with...
Mitani, K, Fujita, H, Sassa, S, Kappas, A
Haem oxygenase is a heat-shock protein in several rat tissues, as well as in certain human cells such as Hep3B hepatoma cells. In common with other heat-shock-protein genes, both the human and the...
The heme-cytochrome P-450 complexes represent sensitive metabolic systems for examining the biological impact of metals on important cellular functions. Many metals, both in the inorganic form and...
Diagnosis of pseudomembranous colitis.
Kappas, A, Shinagawa, N, Arabi, Y, Thompson, H, Burdon, D, Dimock, F, ...
Twenty-eight patients with histologically proved pseudomembranous colitis have been seen in one hospital since July 1975. All patients with the disease had received antibiotics, six for infections...
Abraham, N G, Lavrovsky, Y, Schwartzman, M L, Stoltz, R A, Levere, R D, Gerritsen, M E, ...
Heme oxygenase (HO) is a stress protein and has been suggested to participate in defense mechanisms against agents that may induce oxidative injury such as metals, endotoxin, heme/hemoglobin, and...
Lavrovsky, Y, Schwartzman, M L, Levere, R D, Kappas, A, Abraham, N G
Heme oxygenase (HO) is the rate-limiting enzyme in heme catabolism and its activity is induced by many agents, including its substrate heme, heavy metals, UV radiation, and other injurious oxidant...
The molecular defect of ferrochelatase in a patient with erythropoietic protoporphyria.
Nakahashi, Y, Fujita, H, Taketani, S, Ishida, N, Kappas, A, Sassa, S
The molecular basis of an inherited defect of ferrochelatase in a patient with erythropoietic protoporphyria (EPP) was investigated. Ferrochelatase is the terminal enzyme in the heme biosynthetic...
Levere, R D, Gong, Y F, Kappas, A, Bucher, D J, Wormser, G P, Abraham, N G
The effects of heme alone and heme administered together with 3'-azido-3'-deoxythymidine (AZT) on human immunodeficiency virus replication in human peripheral blood lymphocytes and in the H9 cell...
Kappas, A., Georgopoulos, S. G.
Low concentrations of the antibiotic griseofulvin were found to cause increased frequencies of somatic segregation due to chromosome nondisjunction in a diploid strain of Aspergillus nidulans.
Regulation of food intake and body weight by cobalt porphyrins in animals.
Cobalt-substituted protoporphyrin administered subcutaneously to normal adult rats elicited prompt decreases in food intake and sustained decreases in body weight. Repetitive parenteral...
Tin(IV)-protoporphyrin (Sn-protoporphyrin) potently inhibits heme degradation to bile pigments in vitro and in vivo, a property that confers upon this synthetic compound the ability to suppress a...
Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b.
Ishida, N, Inuzuka, C, Tawaragi, Y, Sugita, O, Nakazato, H, Noguchi, T, ...
Kappas, A, Bradlow, H L, Bickers, D R, Alvares, A P
The hepatic enzymes that catalyze drug oxidations and the reductive metabolism of steroid hormones to 5alpha-derivatives are localized in membranes of the endoplasmic reticulum. Phenobarbital, which...
The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology.
An experimental method is described to deplete markedly in vivo the cytochrome P-450 content of liver for prolonged periods of time. The method uses the synthetic metalloporphyrin cobalt-heme (cobalt...
Thyroid hormone regulation of heme oxidation in the liver.
Smith, T J, Drummond, G S, Kourides, I A, Kappas, A
The effects of 3,5,3'-triiodothyronine (T3) on heme oxygenase (EC 1.14.99.3) activity and cytochrome P-450 content in liver were examined in thyroidectomized rats. T3, when administered for 5 days at...
The effects of various metalloporphyrins on hepatic heme oxygenase (EC 1.14.99.3) activity were examined in order to identify compounds that could inhibit heme degradation to bile pigment and might...
Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.
Fishman, J, Bradlow, H L, Schneider, J, Anderson, K E, Kappas, A
The oxidative metabolism of estradiol was studied in normal men and women by a radiometric procedure that provides information on the totality of the biotransformations concerned. The release of 3H...
Sassa, S, Zalar, G L, Poh-Fitzpatrick, M B, Anderson, K E, Kappas, A
In this paper we show that the ferrochelatase defect in erythropoietic protoporphyria (EPP) can readily be identified in mitogen-stimulated lymphocytes since such cells from patients with EPP...
Schneider, J, Sassa, S, Kappas, A
The oxidative metabolism of estradiol (the natural estrogen 2,3,5(10)-estratriene-3,17 beta-diol) at positions C-2 and C-16 was examined in primary cultures of chick embryo liver cells using...
Whetsell, W O, Sassa, S, Kappas, A
Well-myelinated cultures of mouse dorsal root ganglia incubated for 48 h with sigma-aminolevulinic acid (ALA) showed intense porphyrin fluorescence localized in myelin sheaths but not in axons or...
Sassa, S., Granick, S., Bickers, D. R., Bradlow, H. L., Kappas, A.
A new spectrofluorometric assay is described for quantitating uroporphyrinogen I synthase (EC 4.3.1.8) activity in volumes of human blood as small as 2 μl. By this sensitive assay the inheritance of...
Kappas, A, Simionatto, C S, Drummond, G S, Sassa, S, Anderson, K E
TinIV-protoporphyrin IX (Sn-protoporphyrin) potently inhibits heme degradation to bilirubin in vitro and in vivo, and it completely suppresses neonatal hyperbilirubinemia in experimental animals,...
Control of heme metabolism with synthetic metalloporphyrins.
Studies with synthetic metal-porphyrin complexes in which the central iron atom of heme is replaced by other elements indicate that those heme analogues that cannot be enzymatically degraded to bile...
Kappas, A, Drummond, G S, Sardana, M K
Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, the rate-limiting enzyme in heme degradation to bile pigment, and has been successfully utilized to suppress hyperbilirubinemia...
Sn(tin)-protoporphyrin, a potent competitive inhibitor of heme oxygenase, can suppress hyperbilirubinemia in animal neonates and significantly reduce plasma bilirubin levels in animals and man. To...
Simionatto, C S, Anderson, K E, Drummond, G S, Kappas, A
The synthetic heme analogue Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, the rate-limiting enzyme in heme degradation to bile pigment, and can entirely suppress...
Galbraith, R A, Drummond, G S, Kappas, A
The ability of Sn(tin)-protoporphyrin to inhibit the induction of hepatic delta-aminolevulinate (ALA) synthase by allylisopropyl acetamide (AIA) was examined in the adult rat. Doses of...
Fujita, H, Sassa, S, Toback, A C, Kappas, A
Hepatoerythropoietic porphyria (HEP) is due to a marked deficiency of uroporphyrinogen (URO) decarboxylase, a cytosolic enzyme in the heme biosynthetic pathway. Using a radioimmunoassay method, we...
A model of experimental postnatal hyperbilirubinemia in the rat has been developed utilizing the heme precursor delta-aminolevulinic acid (ALA) to produce jaundice during a selective time period...
Granick, S., Sassa, S., Granick, J. L., Levere, R. D., Kappas, A.
Three micromethods are described for the assay of enzymes or products of the heme biosynthetic pathway in blood. A fluorometric method for the assay of protoporphyrin may be applied to the rapid...
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.
Maines, M D, Janousĕk, V, Tomio, J M, Kappas, A
Cobalt has complex actions on the metabolism of heme in the liver. In this organ the metal potently induces heme oxygenase (EC 1.14.99.3), and decreases cellular heme and hemoprotein content. The...
Interactions between nutritional factors and drug biotransformations in man.
Alvares, A P, Anderson, K E, Conney, A H, Kappas, A
This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three normal volunteers...
The trace metals nickel and platinum, which are not substrates for ferrochelatase and thus do not form heme in biological systems, were found to act similaryl to cobalt, and heme itself, in...
Selenium was found to be a novel regulator of cellular heme methabolism in that the element induced both the mitochondrial enzyme delta-aminolevulinate synthase [succinyl-CoA:glycine...
Ishida, N, Fujita, H, Fukuda, Y, Noguchi, T, Doss, M, Kappas, A, ...
Cloning and expression of the defective genes for delta-aminolevulinate dehydratase (ALAD) from a patient with inherited ALAD deficiency porphyria (ADP) were carried out. Cloning of cDNAs for the...
Kappas, A, Anderson, K E, Conney, A H, Pantuck, E J, Fishman, J, Bradlow, H L
The in vivo biotransformations of drugs known to be metabolized by enzymes localized in the endoplasmic reticulum of liver can be greatly altered by diet in humans, as we have shown previously....
Mitani, K, Fujita, H, Fukuda, Y, Kappas, A, Sassa, S
The role of inorganic metals and metalloporphyrins in the induction of mRNAs for haem oxygenase and heat-shock protein 70 (hsp70), the two heat-shock proteins, was examined in human HepG2 and Hep3B...
delta-Aminolaevulinate (ALA) synthase, the rate-limiting enzyme in haem biosynthesis in the normal liver, was examined in human HepG2 hepatoma cells. Haemin, up to 100 microM, had no effect on ALA...
The effects of acute-phase inducers and dimethyl sulphoxide (Me2SO) on delta-aminolaevulinate (ALA) synthase in HepG2 cells were examined. Treatment of cells with Me2SO resulted in a significant...
Sassa, S, Sugita, O, Ohnuma, N, Imajo, S, Okumura, T, Noguchi, T, ...
Treatment of cultured chick-embryo liver cells with polychlorinated biphenyls (PCB) results in decreased uroporphyrinogen decarboxylase activity and increased uroporphyrin accumulation. In the...
Galbraith, R A, Sassa, S, Kappas, A
Exposure of cultured human hepatoma cells (Hep G2) to medium containing 2% (v/v) dimethyl sulphoxide resulted in an approximate doubling in the activity of delta-aminolaevulinate dehydratase, an...
Mitani, K, Fujita, H, Sassa, S, Kappas, A
Haem oxygenase is a heat-shock protein in several rat tissues, as well as in certain human cells such as Hep3B hepatoma cells. In common with other heat-shock-protein genes, both the human and the...
De Verneuil, H, Sassa, S, Kappas, A
Treatment of cultured chick embryo hepatocytes with phenobarbital, polychlorinated biphenyl compounds and 2,3,7,8-tetrachlorodibenzo-p-dioxin resulted in increased delta-aminolaevulinate synthase and...
Drummond, G S, Rosenberg, D W, Kappas, A
The induction of hepatic haem oxygenase (EC 1.14.99.3) by a series of metals, organometals and metalloporphyrins was examined in vivo in the presence of compound SKF 525A, which is known to complex...
Rosenberg, D W, Drummond, G S, Cornish, H C, Kappas, A
The administration of organotin compounds to rats in single doses causes a significant and prolonged induction of haem oxygenase and a sustained decrease in haemoprotein content in the liver. The...
Metal ion interactions in the control of haem oxygenase induction in liver and kidney.
Mn2+ and Zn2+ exhibit a striking ability to block the induction by Sn2+ and Ni2+ of haem oxygenase (EC 1.14.99.3) in kidney. The blocking effects of Mn2+ and Zn2+ were found to be greatest on...
Sardana, M K, Sassa, S, Kappas, A
The responses of hepatic delta-aminolaevulinate synthase and microsomal haem oxygenase to inducers were examined in pregnant rats. 2-Allyl-2-isopropylacetamide-mediated induction of...
Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions.
Cobalt ions (Co2+) are potent inducers of haem oxygenase in liver and inhibit microsomal drug oxidation probably by depleting microsomal haem and cytochrome P-450. Complexing of Co2+ ions with...
The heme-cytochrome P-450 complexes represent sensitive metabolic systems for examining the biological impact of metals on important cellular functions. Many metals, both in the inorganic form and...
Diagnosis of pseudomembranous colitis.
Kappas, A, Shinagawa, N, Arabi, Y, Thompson, H, Burdon, D, Dimock, F, ...
Twenty-eight patients with histologically proved pseudomembranous colitis have been seen in one hospital since July 1975. All patients with the disease had received antibiotics, six for infections...
Berglund, L, Angelin, B, Hultcrantz, R, Einarsson, K, Emtestam, L, Drummond, G, ...
Sn(tin4+)-protoporphyrin, a potent competitive inhibitor of haeme oxygenase, the rate limiting enzyme in the degradation of haeme to bile pigments, was given intravenously to six patients with...
Xeropotamos, N, Skopelitou, A, Batsis, C., Kappas, A
We report the clinicopathological findings of two patients with ectopic gastric mucosa within the gall ladder. The first patient, a 78 year old man, was asymptomatic. He was admitted to hospital for...
The in vivo regulation by metal ions of the enzymes of heme metabolism in kidney-particularly of ALAS, the rate-limiting enzyme in heine formation- was investigated. Ni(2+) and Pt(4+), metals which...
Potent heme-degrading action of antimony and antimony-containing parasiticidal agents
The ability of antimony and antimony-containing parasiticidal agents to enhance the rate of heme degradation in liver and kidney was investigated. Trivalent antimony was shown to be an extremely...
Song, C. S., Rubin, W., Rifkind, A. B., Kappas, A.
A method is described for the rapid isolation of a plasma membrane fraction containing a high concentration of intact bile canaliculi from the rat liver. Isolated bile canaliculi retain most of the...
The induction of a carcinogen-metabolizing enzyme in human skin.
Kappas, A., Alvares, A. P., Bickers, D. R., Levin, W., Conney, A.
Sideroblastic anaemia associated with lincomycin therapy.
Kokkini, G., Tsianos, E., Kappas, A.
Sideroblastic anaemia developed after lincomycin therapy in a 58-year-old woman. The anaemia proved completely reversible after termination of lincomycin therapy and the introduction of pyridoxine....