The paper describes the impact of a continuing professional development programme (CPD) on the development of interprofessional practice within a Children and Young People Trust (CYPT) in the South...
Making connections across boundaries: interprofessional learning and communities of practice (2009)
Aim: this paper applies Wenger’s (1998) theory of Communities of Practice (CoP) to Interprofessional Learning (IPL). Using findings from a study to evaluate the pedagogy of one Interprofessional...
Poltawski, L., Edwards, H., Todd, A., Watson, T., Lees, A., James, C.
The original article can be found at: http://www3.interscience.wiley.com Copyright Movement Disorders Society / Wiley. DOI: 10.1002/mds.22316 [Full text of this article is not available in the UHRA]
Cutaneous side effects of infused apomorphine: The patient and care experience (2008)
Poltawski, L., Edwards, H., Todd, A., Watson, T., Lees, A., James, C.
Original article can be found at: http://www.bjnn.co.uk/ Copyright MA Healthcare Limited
Meyer, E., Lees, A., Connell, N., Humphris, D.
This paper is a report of a study assessing the impact on nursing practice of critical care skills training for ward-based nurses. Background: Following a government review of adult critical care...
Measuring quality of life in PSP: the PSP-QoL (2006)
Schrag, A., Selai, C., Quinn, N., Lees, A., Litvan, I., Lang, A., ...
Objective: To develop a new patient-reported outcome measure for progressive supranuclear palsy (PSP) and to test its psychometric properties. Methods: First, the authors generated a pool of...
Silva, R. De, Lashley, T., Strand, C., Shiarli, A.M., Shi, J., Tian, J.Z., ...
The pathological distinctions between the various clinical and pathological manifestations of frontotemporal lobar degeneration (FTLD) remain unclear. Using monoclonal antibodies specific for 3- and...
Rivastigmine for dementia associated with Parkinson's disease (2004)
Emre, M., Aarsland, D., Albanese, A., Byrne, E.J., Deuschl, G., De Deyn, P.P., ...
Background: Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such...
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease (2004)
Paisán-Ruíz, C., Jain, S., Evans, E.W., Gilks, W.G., Simón, J., ...
Parkinson's disease (PD; OMIM #168600) is the second most common neurodegenerative disorder in the Western world and presents as a progressive movement disorder. The hallmark pathological features of...
The structure of the tau haplotype in controls and in progressive supranuclear palsy (2004)
Pittman, A.M., Myers, A.J., Duckworth, J., Bryden, L., Hanson, M., Abou-Sleiman, P., ...
The group of neurodegenerative diseases collectively known as tauopathies are characterized by hallmark lesions consisting of fibrillar aggregates of the microtubule-associated protein, tau (MAPT)....
Performing the vertical jump: Movement adaptations for submaximal jumping (2004)
The purpose of this Study was to gain insight into the kinematics and kinetics of the vertical jump when jumping for different heights and to investigate movement effectiveness as a criterion for...
Performing the vertical jump: Movement adaptations for submaximal jumping (2004)
Vanrenterghem, Jos, LEES, A, Lenoir, Matthieu, AERTS, P, De Clercq, Dirk
De Silva, R., Lashley, T., Gibb, G., Hanger, D., Hope, A., Reid, A., ...
Pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in the tauopathies, which include Alzheimer's disease, frontotemporal dementia...
Descending control of muscles in patients with cervical dystonia (2002)
Tijssen, M.A.J., Munchau, A., Marsden, J.F., Lees, A., Bhatia, K.P., Brown, P.
Clinical genetics of familial progressive supranuclear palsy (1999)
Rojo, A., Pernaute, R. S., Fontán, A., Ruíz, P. G., Honnorat, J., Lynch, T., ...
Recent studies have shown that progressive supranuclear palsy (PSP) could be inherited, but the pattern of inheritance and the spectrum of the clinical findings in relatives are unknown. We here...
Research into the Influence of Rotation on the Internal Cooling of Turbine Blades (1998)
Rowbury, D. A., Parneix, S., Chanteloup, D., Lees, A.
This paper provides an overview of the on-going work in the Brite-EuRam Internal Cooling of Turbine Blades' (ICTB) project. The project is a collaborative, pan-European research program that brings...
Dynamics and Kinetics of Si/Si ̲(1- ̲x ̲)Ge ̲( ̲x ̲) MBE studies by reflectance spectroscopy. (1998)
Thesis (Ph.D.)
THE NEUROLOGY OF OBSESSIONAL SLOWNESS (1991)
HYMAS, N., LEES, A., BOLTON, D., EPPS, K., HEAD, D.
SUMMARY Seventeen of 59 patients admitted to hospital for treatment of Obsessive-Compulsive Disorder (OCD) were found to have significant slowness, mainly due to difficulty in initiating...
Chang, Q., Zhong, Z., Lees, A., Pekna, M., Pirofski, L.
To investigate the influence of antibody structure and specificity on antibody efficacy against Streptococcus pneumoniae, human monospecific antibodies (MAbs) to serotype 3 pneumococcal capsular...
Ak, M, Bower, J H, Hoffman, S L, Sedegah, M, Lees, A, Carter, M, ...
Passive transfer of monoclonal antibodies (MAbs) against malaria circumsporozoite (CS) proteins protects animals against malaria. Active immunization with synthetic or recombinant peptides induces a...
Chang, Q., Zhong, Z., Lees, A., Pekna, M., Pirofski, L.
To investigate the influence of antibody structure and specificity on antibody efficacy against Streptococcus pneumoniae, human monospecific antibodies (MAbs) to serotype 3 pneumococcal capsular...
Ak, M, Bower, J H, Hoffman, S L, Sedegah, M, Lees, A, Carter, M, ...
Passive transfer of monoclonal antibodies (MAbs) against malaria circumsporozoite (CS) proteins protects animals against malaria. Active immunization with synthetic or recombinant peptides induces a...
Die bydrae van eenheidsbestuurders in die opleiding van studentverpleegkundiges /
Proefskrif (M.Cur.)--Randse Afrikaanse Universiteit, 1989.
Intranasal apomorphine: a new treatment in Parkinson's disease.
Kapoor, R, Turjanski, N, Frankel, J, Kleedorfer, B, Lees, A, Stern, G, ...
Sandler, M, Ruthven, C R, Goodwin, B L, Lees, A, Stern, G M
In a group of six Parkinsonian patients and 13 "controls" with non-Parkinsonian neurological disease, there was a high correlation between both free and conjugated phenylacetic acid concentrations in...
The use of botulinum toxin in the treatment of adductor spasmodic dysphonia.
Whurr, R, Lorch, M, Fontana, H, Brookes, G, Lees, A, Marsden, C D
Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid...
Oligoclonal banding in the cerebrospinal fluid of patients with postencephalitic Parkinsonism.
Williams, A, Houff, S, Lees, A, Calne, D B
Two recent sporadic cases of progressive Parkinsonism after encephalitis are described. Both patients had two oligoclonal protein bands in their CSF. These bands were not present in patients with...
Injury risk associated with playing actions during competitive soccer
Rahnama, N, Reilly, T, Lees, A
Objective: To assess the exposure of players to injury risk during English Premier League soccer matches in relation to selected factors.
DJ-1 mutations in Parkinson's disease
Healy, D, Abou-Sleiman, P, Valente, E, Gilks, W, Bhatia, K, Quinn, N, ...
Parkinson's syndrome after closed head injury: a single case report
Doder, M, Jahanshahi, M, Turjanski, N, Moseley, I, Lees, A
A 36 year old man, who sustained a skull fracture in 1984, was unconscious for 24 hours, and developed signs of Parkinson's syndrome 6 weeks after the injury. When assessed in 1995, neuroimaging...
OBJECTIVE—It has been suggested that the basal ganglia act to release cortical elements from idling (α) rhythms so that they may become coherent in the γ range, thereby binding together those...
Morris, H, Janssen, J, Bandmann, O, Daniel, S, Rossor, M, Lees, A, ...
Unilateral pallidotomy for Parkinson's disease: results after more than 1 year
Schrag, A, Samuel, M, Caputo, E, Scaravilli, T, Troyer, M, Marsden, C, ...
OBJECTIVE—To examine follow up results of unilateral ventral medial pallidotomy in 22 patients with advanced Parkinson's disease more than 1 year after the operation in comparison with their...
Giovannoni, G, Van Schalkwyk, J, Fritz, V, Lees, A
OBJECTIVES—A simple and rapid computerised keyboard test, based on the alternating finger tapping test, has been developed to quantify upper limb motor function. The test generates several...
Late onset startle induced tics
Tijssen, M, Brown, P, Morris, H, Lees, A
Three cases of late onset Gilles de la Tourette's syndrome are presented. The motor tics were mainly induced by an unexpected startling stimulus, but the startle reflex was not exaggerated. The tics...
An ambulatory dyskinesia monitor
Manson, A, Brown, P, O'Sullivan, J, Asselman, P, Buckwell, D, Lees, A
OBJECTIVES—New treatments are now becoming available for the management of levodopa induced dyskinesias in Parkinsons's disease. However, assessment of their efficacy is limited by the inadequacies...
Chawda, S, Munchau, A, Johnson, D, Bhatia, K, Quinn, N, Stevens, J, ...
OBJECTIVES—To characterise the pattern of and risk factors for degenerative changes of the cervical spine in patients with spasmodic torticollis and to assess whether these changes affect outcome...
Wenning, G, Ben-Shlomo, Y, Hughes, A, Daniel, S, Lees, A, Quinn, N
OBJECTIVES—Few studies have attempted to identify what premortem features best differentiate multiple system atrophy (MSA) from Parkinson`s disease (PD). These studies are limited by small sample...
Giovannoni, G, O'Sullivan, J, Turner, K, Manson, A, Lees, A
Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine...
High dose naltrexone for dyskinesias induced by levodopa
Manson, A, Katzenschlager, R, Hobart, J, Lees, A
Ten patients with Parkinson's disease and levodopa induced dyskinesias (LIDs) took part in this randomised, placebo controlled, double blind, crossover trial to assess the efficacy and tolerability...
Reporting clinical trials: full access to all the data
Rosenberg, R, Aminoff, M, BoIler, F, Soerensen, P, Griggs, R, Hachinski, V, ...
Sequence analysis of tau in familial and sporadic progressive supranuclear palsy
Morris, H, Katzenschlager, R, Janssen, J, Brown, J, Ozansoy, M, Quinn, N, ...
Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis
Church, A, Dale, R, Lees, A, Giovannoni, G, Robertson, M
Background: The classical neurological disorder after group A ß haemolytic streptococcal infection is Sydenham's chorea. Recently a tic disorder occurring after group A streptococcal infection has...
Lewy body cortical involvement may not always predict dementia in Parkinson's disease
Colosimo, C, Hughes, A, Kilford, L, Lees, A
Background: The presence of Lewy bodies (LB) in the neocortex and limbic system in patients with Parkinson's disease (PD) is commonly thought to be linked with cognitive impairment. The authors...
Olfactory function distinguishes vascular parkinsonism from Parkinson's disease
Katzenschlager, R, Zijlmans, J, Evans, A, Watt, H, Lees, A
Methods: The University of Pennsylvania smell identification test (UPSIT) was carried out in 14 patients with vascular parkinsonism, 18 with Parkinson's disease, and 27 normal controls matched for...
Paviour, D, Schott, J, Stevens, J, Revesz, T, Holton, J, Rossor, M, ...
Objective: To investigate whether regions of increased atrophy rates demonstrated in PSP during life using fluid registered serial MRI correspond with pathological findings in confirmed PSP.
Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study
Katzenschlager, R, Evans, A, Manson, A, Patsalos, P, Ratnaraj, N, Watt, H, ...
Background: The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have assessed the clinical...
Katzenschlager, R, Manson, A, Evans, A, Watt, H, Lees, A
Methods: Nine patients with PD were enrolled and received 25 mg of quetiapine or placebo at night for two weeks in prerandomised order, with one week of wash out between treatment periods....
The L-dopa response in vascular parkinsonism
Zijlmans, J, Katzenschlager, R, Daniel, S, Lees, A
Objective: To determine whether a positive L-dopa response in vascular parkinsonism (VP) is correlated with the presence of nigrostriatal pathology due to either vascular damage or neuronal cell loss.
Tau gene and Parkinson's disease: a case–control study and meta-analysis
Healy, D, Abou-Sleiman, P, Lees, A, Casas, J, Quinn, N, Bhatia, K, ...
Objective: To investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson's disease and to report a meta-analysis on all previously published data
Nath, U, Thomson, R, Wood, R, Ben-Shlomo, Y, Lees, A, Rooney, C, ...
Objective: To estimate the mortality of progressive supranuclear palsy (PSP) and to assess the quality of death certification in patients with PSP who died in England and Wales.
DJ-1 mutations in Parkinson's disease
Healy, D, Abou-Sleiman, P, Valente, E, Gilks, W, Bhatia, K, Quinn, N, ...
Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson's disease
Churchyard, A, Mathias, C, Boonkongchuen, P, Lees, A
OBJECTIVES—The United Kingdom Parkinson's Disease Research Group (UKPDRG) trial found an increased mortality in patients with Parkinson's disease randomised to receive selegiline (10 mg/day) and...
OBJECTIVE—A previous study of botulinum toxin type F (BTX-F) treatment for torticollis had shown a dose of 520 MU to be effective, but for a much shorter duration than is usual with botulinum toxin...
OBJECTIVES—To determine whether continous waking day dopaminergic stimulation with the dopamine agonist apomorphine can reduce levodopa induced dyskinesias in Parkinson's disease METHODS—19...
Clinical usefulness of magnetic resonance imaging in multiple system atrophy
Schrag, A, Kingsley, D, Phatouros, C, Mathias, C, Lees, A, Daniel, S, ...
OBJECTIVES—To determine the sensitivity, specificity, and positive predictive values of a selection of abnormal findings in the putamen and infratentorial structures on routine magnetic resonance...
Autonomic effects of selegiline: possible cardiovascular toxicity in Parkinson's disease
COYLE, J., HOBSON, P., MEARA, J., HEINONEN, E., MYLLYLA, V., CHURCHYARD, A., ...
Progressive supranuclear palsy (Steele-Richardson-Olszewski disease)
Morris, H., Wood, N., Lees, A.
Progressive supranuclear palsy is a neurodegenerative disease which affects the brainstem and basal ganglia. Patients present with disturbance of balance, a disorder of downward gaze and...
Pittman, A, Myers, A, Abou-Sleiman, P, Fung, H, Kaleem, M, Marlowe, L, ...
Background: The haplotype H1 of the tau gene, MAPT, is highly associated with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).