Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.
McFadden, D C, Powles, M A, Smith, J G, Flattery, A M, Bartizal, K, Schmatz, D M
A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been...
Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.
McFadden, D C, Powles, M A, Smith, J G, Flattery, A M, Bartizal, K, Schmatz, D M
A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been...
Efficacy of Caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans▿
Bowman, J. C., Abruzzo, G. K., Flattery, A. M., Gill, C. J., Hickey, E. J., Hsu, M. J., ...
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-β-d-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated...