Scientific Commons: A. M. Rofe

Background: Oral administration of zinc or bovine whey-derived growth factor extract (WGFE) is known to reduce intestinal permeability and ameliorate methotrexate (MTX)-induced mucositis,...

Zinc treatment prevents lipopolysaccharide-induced teratogenicity in mice (2003)

Carey, L. C., Berbee, P. L., Coyle, P., Philcox, J. C., Rofe, A. M.

Zinc supplementation at the time of ethanol exposure ameliorates teratogenicity in mice (2003)

Carey, L. C., Coyle, P., Philcox, J. C., Rofe, A. M.

Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine (2003)

Tran, C. D., Howarth, G. S., Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N.

Zinc inhibition of hepatic fructose metabolism in rats (2003)

Coyle, P., Tichelman, E. M., Pauw, R. T., Philcox, J. C., Rofe, A. M.

Zinc treatment prevents lipopolysaccharide-induced teratogenicity in mice (2003)

Carey, L. C., Berbee, P. L., Coyle, P., Philcox, J. C., Rofe, A. M.

Helicobacter-induced gastritis in mice not expressing metallothionein-I and II (2003)

Tran, C. D., Huynh, H. Q., Berg, M Van Den, Pas, M Van Der, Campbell, M. A.F., Philcox, J. C., ...

Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine (2003)

Tran, C. D., Howarth, G. S., Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N.

Helicobacter-induced gastritis in mice not expressing metallothionein-I and II (2003)

Tran, C. D., Huynh, H. Q., Berg, M Van Den, Pas, M Van Der, Campbell, M. A.F., Philcox, J. C., ...

Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine (2003)

Tran, C. D., Howarth, Gordon Stanley, Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N.

Background: Oral administration of zinc or bovine whey-derived growth factor extract (WGFE) is known to reduce intestinal permeability and ameliorate methotrexate (MTX)-induced mucositis,...

Zinc supplementation at the time of ethanol exposure ameliorates teratogenicity in mice (2003)

Carey, L. C., Coyle, P., Philcox, J. C., Rofe, A. M.

Zinc inhibition of hepatic fructose metabolism in rats (2003)

Coyle, P., Tichelman, E. M., Pauw, R. T., Philcox, J. C., Rofe, A. M.

Zinc treatment prevents lipopolysaccharide-induced teratogenicity in mice (2003)

Carey, L. C., Berbee, P. L., Coyle, P., Philcox, J. C., Rofe, A. M.

Helicobacter-induced gastritis in mice not expressing metallothionein-I and II (2003)

Tran, C. D., Huynh, H. Q., Berg, M Van Den, Pas, M Van Der, Campbell, M. A.F., Philcox, J. C., ...

Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation (2002)

Truong-Tran, A. Q., Ruffin, Richard Ernest, Foster, P. S., Koskinen, A. M., Coyle, P., Philcox, J. C., ...

Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma (2002)

Coyle, P., Mathew, G., Game, P. A., Myers, J. C., Philcox, J. C., Rofe, A. M., ...

Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation (2002)

Truong-Tran, A. Q., Ruffin, R. E., Foster, P. S., Koskinen, A. M., Coyle, P., Philcox, J. C., ...

Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma (2002)

Coyle, P., Mathew, G., Game, P. A., Myers, J. C., Philcox, J. C., Rofe, A. M., ...

Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation (2002)

Truong-Tran, A. Q., Ruffin, Richard Ernest, Foster, P. S., Koskinen, A. M., Coyle, P., Philcox, J. C., ...

Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma (2002)

Coyle, P., Mathew, G., Game, P. A., Myers, J. C., Philcox, J. C., Rofe, A. M., ...

The effect of immune enhancement and suppression on the development of laparoscopic port site metastases (2000)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T. S., Rofe, A. M., Jamieson, G. G.

The effect of immune enhancement and suppression on the development of laparoscopic port site metastases (2000)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T. S., Rofe, A. M., Jamieson, G. G.

Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice (2000)

Carey, L. C., Coyle, P., Philcox, J. C., Rofe, A. M.

Maternal ethanol exposure is associated with decreased plasma zinc and increased fetal abnormalities in normal but not metallothionein-null mice (2000)

Carey, L. C., Coyle, P., Philcox, J. C., Rofe, A. M.

The effect of immune enhancement and suppression on the development of laparoscopic port site metastases (2000)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T. S., Rofe, A. M., Jamieson, G. G.

Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice (2000)

Carey, L. C., Coyle, P., Philcox, J. C., Rofe, A. M.

Maternal ethanol exposure is associated with decreased plasma zinc and increased fetal abnormalities in normal but not metallothionein-null mice (2000)

Carey, L. C., Coyle, P., Philcox, J. C., Rofe, A. M.

Regional distribution and localization of zinc and metallothionein in the intestine of rats fed diets differing in zinc content (1999)

Tran, C. D., Butler, R. N., Howarth, G. S., Philcox, J. C., Rofe, A. M., Coyle, P.

In vitro inhibition of tumour growth in a helium rich environment - Implications for laparoscopic surgery (1999)

Neuhaus, Susan Josephine, Ellis, T. S., Barrett, M. W., Rofe, A. M., Jamieson, G. G., Watson, D. I.

The role of peritoneal immunity and the tumour-bearing state on the development of wound and peritoneal metastases after laparoscopy (1999)

Mathew, G., Watson, D. I., Ellis, T. S., Jamieson, G. G., Rofe, A. M.

Influence of cytotoxic agents on intraperitoneal tumor implantation after laparoscopy (1999)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T., Rofe, A. M., Jamieson, G. G.

Regional Distribution and Localization of Zinc and Metallothionein in the Intestine of Rats Fed Diets Differing in Zinc Content (1999)

Tran, C. D., Butler, R. N., Howarth, G. S., Philcox, J. C., Rofe, A. M., Coyle, P.

Regional distribution and localization of zinc and metallothionein in the intestine of rats fed diets differing in zinc content (1999)

Tran, C. D., Butler, R. N., Howarth, G. S., Philcox, J. C., Rofe, A. M., Coyle, P.

In vitro inhibition of tumour growth in a helium rich environment - Implications for laparoscopic surgery (1999)

Neuhaus, Susan Josephine, Ellis, T. S., Barrett, M. W., Rofe, A. M., Jamieson, G. G., Watson, D. I.

The role of peritoneal immunity and the tumour-bearing state on the development of wound and peritoneal metastases after laparoscopy (1999)

Mathew, G., Watson, D. I., Ellis, T. S., Jamieson, G. G., Rofe, A. M.

Influence of cytotoxic agents on intraperitoneal tumor implantation after laparoscopy (1999)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T., Rofe, A. M., Jamieson, G. G.

Regional Distribution and Localization of Zinc and Metallothionein in the Intestine of Rats Fed Diets Differing in Zinc Content (1999)

Tran, C. D., Butler, R. N., Howarth, G. S., Philcox, J. C., Rofe, A. M., Coyle, P.

Regional Distribution of Metallothionein and Zinc in the Mouse Gut - Comparison With Metallothionien-Null Mice (1998)

Tran, C. D., Butler, R. N., Philcox, J. C., Rofe, A. M., Howarth, G. S., Coyle, P.

Efficacy of cytotoxic agents for the prevention of laparoscopic port-site metastases (1998)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T., Dodd, T., Rofe, A. M., Jamieson, G. G.

In vitro inhibition of tumour frowth in a helium-rich environment: implications for laparoscopic surgery (1998)

Neuhaus, Susan Josephine, Ellis, T. S., Barrett, M. W., Rofe, A. M., Jamieson, G. G., Watson, D. I.

Wound metastasis after laparoscopy with different insufflation gases (1998)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T., Rowland, R., Rofe, A. M., Pike, G. K., ...

Tumor implantation following laparoscopy using different insufflation gases (1998)

Neuhaus, Susan Josephine, Ellis, T., Rofe, A. M., Pike, G. K., Jamieson, G. G., Watson, D. I.

Regional Distribution of Metallothionein and Zinc in the Mouse Gut (1998)

Tran, C. D., Butler, R. N., Philcox, J. C., Rofe, A. M., Howarth, G. S., Coyle, P.

Regional Distribution of Metallothionein and Zinc in the Mouse Gut - Comparison With Metallothionien-Null Mice (1998)

Tran, C. D., Butler, R. N., Philcox, J. C., Rofe, A. M., Howarth, G. S., Coyle, P.

Efficacy of cytotoxic agents for the prevention of laparoscopic port-site metastases (1998)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T., Dodd, T., Rofe, A. M., Jamieson, G. G.

In vitro inhibition of tumour frowth in a helium-rich environment: implications for laparoscopic surgery (1998)

Neuhaus, Susan Josephine, Ellis, T. S., Barrett, M. W., Rofe, A. M., Jamieson, G. G., Watson, D. I.

Wound metastasis after laparoscopy with different insufflation gases (1998)

Neuhaus, Susan Josephine, Watson, D. I., Ellis, T., Rowland, R., Rofe, A. M., Pike, G. K., ...

Tumor implantation following laparoscopy using different insufflation gases (1998)

Neuhaus, Susan Josephine, Ellis, T., Rofe, A. M., Pike, G. K., Jamieson, G. G., Watson, D. I.

Regional Distribution of Metallothionein and Zinc in the Mouse Gut (1998)

Tran, C. D., Butler, R. N., Philcox, J. C., Rofe, A. M., Howarth, G. S., Coyle, P.

Gasless laparoscopy may reduce the risk of port-site metastases following laparascopic tumor surgery (1997)

Watson, D. I., Mathew, G., Ellis, T., Baigrie, C. F., Rofe, A. M., Jamieson, G. G.

Adverse impact of pneumoperitoneum on intraperitoneal implantation and growth of tumour cell suspension in an experimental model (1997)

Mathew, G., Watson, D. I., Rofe, A. M., Ellis, T., Jamieson, G. G.

(D)-penicillamine increases hepatic oxalate production resulting in hyperoxaluria (1997)

Baker, Paul Wayne, Bais, Renz, Rofe, A. M.

Gasless laparoscopy may reduce the risk of port-site metastases following laparoscopic tumor surgery (1997)

Watson, D. I., Mathew, G., Ellis, T., Baigrie, C. F., Rofe, A. M., Jamieson, G. G.

Adverse impact of pneumoperitoneum on intraperitoneal implantation and growth of tumour cell suspension in an experimental model (1997)

Mathew, G., Watson, D. I., Rofe, A. M., Ellis, T., Jamieson, G. G.

The effect of laparoscopy on the movement of tumor cells and metastasis to surgical wounds (1997)

Mathew, G., Watson, D. I., Ellis, T., De Young, N., Rofe, A. M., Jamieson, G. G.

Metallothionein: Regulation of intestinal zinc (1997)

Tran, C. D., Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N., Howarth, G. S.

Metallothionein and zinc in methotrexate-induced damage in rats (1997)

Tran, C. D., Howarth, G. S., Butler, R. N., Coyle, P., Philcox, J. C., Rofe, A. M.

Gasless laparoscopy may reduce the risk of port-site metastases following laparascopic tumor surgery (1997)

Watson, D. I., Mathew, G., Ellis, T., Baigrie, C. F., Rofe, A. M., Jamieson, G. G.

Adverse impact of pneumoperitoneum on intraperitoneal implantation and growth of tumour cell suspension in an experimental model (1997)

Mathew, G., Watson, D. I., Rofe, A. M., Ellis, T., Jamieson, G. G.

(D)-penicillamine increases hepatic oxalate production resulting in hyperoxaluria (1997)

Baker, Paul Wayne, Bais, Renz, Rofe, A. M.

Gasless laparoscopy may reduce the risk of port-site metastases following laparoscopic tumor surgery (1997)

Watson, D. I., Mathew, G., Ellis, T., Baigrie, C. F., Rofe, A. M., Jamieson, G. G.

Adverse impact of pneumoperitoneum on intraperitoneal implantation and growth of tumour cell suspension in an experimental model (1997)

Mathew, G., Watson, D. I., Rofe, A. M., Ellis, T., Jamieson, G. G.

The effect of laparoscopy on the movement of tumor cells and metastasis to surgical wounds (1997)

Mathew, G., Watson, D. I., Ellis, T., De Young, N., Rofe, A. M., Jamieson, G. G.

Metallothionein: Regulation of intestinal zinc (1997)

Tran, C. D., Coyle, P., Philcox, J. C., Rofe, A. M., Butler, R. N., Howarth, G. S.

Metallothionein and zinc in methotrexate-induced damage in rats (1997)

Tran, C. D., Howarth, G. S., Butler, R. N., Coyle, P., Philcox, J. C., Rofe, A. M.

Trace metal, acute phase and metabolic response to endotoxin in metallothionen-null mice (1996)

Rofe, A. M., Philcox, J. C., Coyle, P.

Wound metastases following laparascopic and open surgery for abdominal cancer in a rat model (1996)

Mathew, G., Watson, D. I., Rofe, A. M., Baigrie, C. F., Ellis, T., Jamieson, G. G.

In vivo studies of macrophages and intercellular adhesion molecule-1 following lipopolysaccharide treatment in tumour-bearing rats (1996)

Nilsson, T. M., Woods, A. E., Rofe, A. M.

Wound metastases following laparoscopic and open surgery for abdominal cancer in a rat model (1996)

Mathew, G., Watson, D. I., Rofe, A. M., Baigrie, C. F., Ellis, T., Jamieson, G. G.

Trace metal, acute phase and metabolic response to endotoxin in metallothionen-null mice (1996)

Rofe, A. M., Philcox, J. C., Coyle, P.

Wound metastases following laparascopic and open surgery for abdominal cancer in a rat model (1996)

Mathew, G., Watson, D. I., Rofe, A. M., Baigrie, C. F., Ellis, T., Jamieson, G. G.

In vivo studies of macrophages and intercellular adhesion molecule-1 following lipopolysaccharide treatment in tumour-bearing rats (1996)

Nilsson, T. M., Woods, A. E., Rofe, A. M.

Wound metastases following laparoscopic and open surgery for abdominal cancer in a rat model (1996)

Mathew, G., Watson, D. I., Rofe, A. M., Baigrie, C. F., Ellis, T., Jamieson, G. G.

Hepatic zinc in metallothionein-null mile following zinc challenge: In vivo and in vitro studies (1995)

Coyle, P., Philcox, J. C., Rofe, A. M.

Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metalluthionein gene expression (1995)

Philcox, J. C., Coyle, P., Michalska, A., Choo, C. H., Rofe, A. M.

Metallothionein induction in cultured rat hepatocytes byarthritic rat serum, activated macrophages, IL-6 IL-11 and leukaemia inhibitory factor (1995)

Coyle, P., Philcox, J. C., Rofe, A. M.

Hepatic zinc in metallothionein-null mile following zinc challenge: In vivo and in vitro studies (1995)

Coyle, P., Philcox, J. C., Rofe, A. M.

Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metalluthionein gene expression (1995)

Philcox, J. C., Coyle, P., Michalska, A., Choo, C. H., Rofe, A. M.

Metallothionein induction in cultured rat hepatocytes byarthritic rat serum, activated macrophages, IL-6 IL-11 and leukaemia inhibitory factor (1995)

Coyle, P., Philcox, J. C., Rofe, A. M.

Xylitol metabolism and oxalate synthesis in the rat (1978)

Rofe, A. M.

vi, 90 leaves : tables, graphs ; 30 cm.

Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies.

Coyle, P, Philcox, J C, Rofe, A M

Hepatic zinc uptake and accumulation were compared in freshly isolated and cultured hepatocytes prepared from control (MT+/+) and metallothionein (MT)-null (MT-/-) mice. In freshly isolated...

Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression.

Philcox, J C, Coyle, P, Michalska, A, Choo, K H, Rofe, A M

The action of endotoxin lipopolysaccharide (LPS) on hepatic Zn uptake was examined in mice lacking expression of metallothionein (MT)-1 and MT-II genes. Hepatic Zn concentrations, which in normal...

Effects of insulin and insulin-like growth factors on protein and energy metabolism in tumour-bearing rats.

Tomas, F M, Chandler, C S, Coyle, P, Bourgeois, C S, Burgoyne, J L, Rofe, A M

The effects of insulin-like growth factor-1 (IGF-I), and a more potent variant LR3-IGF-I, which binds poorly to IGF-binding proteins, were investigated in rats bearing a mammary adenocarcinoma. The...

Formation of the L-cysteine-glyoxylate adduct is the mechanism by which L-cysteine decreases oxalate production from glycollate in rat hepatocytes.

Baker, P W, Bais, R, Rofe, A M

Formation of thiazolidine-2,4-dicarboxylic acid, the L-cysteine-glyoxylate adduct, is the putative mechanism by which L-cysteine reduces hepatic oxalate production from glycollate [Bais, Rofe and...

Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc.

Coyle, P, Zalewski, P D, Philcox, J C, Forbes, I J, Ward, A D, Lincoln, S F, ...

Zinquin [ethyl (2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetate], a new intracellular zinc fluorophore, was used to reveal and to measure Zn in cultured rat hepatocytes before and after...

The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations.

Rofe, A M, Conyers, R A, Bais, R, Gamble, J R, Vadas, M A

Tumour necrosis factor (TNF) did not stimulate lipolysis in isolated rat adipocytes, though preincubation with TNF increased adrenaline-stimulated fatty acid release. Glycogenolysis, gluconeogenesis...

The effect of tumour-bearing on 2-deoxy[U-14C]glucose uptake in normal and neoplastic tissues in the rat.

Rofe, A M, Bourgeois, C S, Bais, R, Conyers, R A

The extent to which normal and neoplastic tissues of the rate take up glucose was assessed by the 2-deoxy[U-14C]glucose tracer technique. Measurements of glucose uptake were made over 40 min in...

Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia.

Rofe, A M, Williamson, D H

The effects of vasopressin on the metabolism of starved rats were investigated by using a constant-infusion regimen (50 pmol/kg body wt. per min, after an initial loading dose of 150 pmol/kg body...

The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol.

Bais, R, James, H M, Rofe, A M, Conyers, R A

Ketohexokinase (EC 2.7.1.3) was purified to homogeneity from human liver, and fructose-bisphosphate aldolase (EC 4.1.2.13) was partially purified from the same source. Ketohexokinase was shown, by...

Ketone-body metabolism in tumour-bearing rats.

Rofe, A M, Bais, R, Conyers, R A

During starvation for 72 h, tumour-bearing rats showed accelerated ketonaemia and marked ketonuria. Total blood [ketone bodies] were 8.53 mM and 3.34 mM in tumour-bearing and control...

Mechanism for the 'anti-lipolytic' action of vasopressin in the starved rat.

Rofe, A M, Williamson, D H

The marked decrease in blood non-esterified fatty acids and ketone bodies after vasopressin infusion into starved rats [Rofe & Williamson (1983) Biochem. J. 212, 231-239] was investigated....

Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice.

Rofe, A M, Philcox, J C, Coyle, P

Accumulation of hepatic zinc via metallothionein (MT) induction during infection/inflammation is postulated to benefit a range of metabolic processes. The metabolic consequences of two doses of...

Nutrition and cancer.

Conyers, R A, Need, A G, Rofe, A M, Potezny, N, Kimber, R J

Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies.

Coyle, P, Philcox, J C, Rofe, A M

Hepatic zinc uptake and accumulation were compared in freshly isolated and cultured hepatocytes prepared from control (MT+/+) and metallothionein (MT)-null (MT-/-) mice. In freshly isolated...

Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression.

Philcox, J C, Coyle, P, Michalska, A, Choo, K H, Rofe, A M

The action of endotoxin lipopolysaccharide (LPS) on hepatic Zn uptake was examined in mice lacking expression of metallothionein (MT)-1 and MT-II genes. Hepatic Zn concentrations, which in normal...

Effects of insulin and insulin-like growth factors on protein and energy metabolism in tumour-bearing rats.

Tomas, F M, Chandler, C S, Coyle, P, Bourgeois, C S, Burgoyne, J L, Rofe, A M

The effects of insulin-like growth factor-1 (IGF-I), and a more potent variant LR3-IGF-I, which binds poorly to IGF-binding proteins, were investigated in rats bearing a mammary adenocarcinoma. The...

Formation of the L-cysteine-glyoxylate adduct is the mechanism by which L-cysteine decreases oxalate production from glycollate in rat hepatocytes.

Baker, P W, Bais, R, Rofe, A M

Formation of thiazolidine-2,4-dicarboxylic acid, the L-cysteine-glyoxylate adduct, is the putative mechanism by which L-cysteine reduces hepatic oxalate production from glycollate [Bais, Rofe and...

Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc.

Coyle, P, Zalewski, P D, Philcox, J C, Forbes, I J, Ward, A D, Lincoln, S F, ...

Zinquin [ethyl (2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetate], a new intracellular zinc fluorophore, was used to reveal and to measure Zn in cultured rat hepatocytes before and after...

The effects of recombinant tumour necrosis factor (cachectin) on metabolism in isolated rat adipocyte, hepatocyte and muscle preparations.

Rofe, A M, Conyers, R A, Bais, R, Gamble, J R, Vadas, M A

Tumour necrosis factor (TNF) did not stimulate lipolysis in isolated rat adipocytes, though preincubation with TNF increased adrenaline-stimulated fatty acid release. Glycogenolysis, gluconeogenesis...

The effect of tumour-bearing on 2-deoxy[U-14C]glucose uptake in normal and neoplastic tissues in the rat.

Rofe, A M, Bourgeois, C S, Bais, R, Conyers, R A

The extent to which normal and neoplastic tissues of the rate take up glucose was assessed by the 2-deoxy[U-14C]glucose tracer technique. Measurements of glucose uptake were made over 40 min in...

Metabolic effects of vasopressin infusion in the starved rat. Reversal of ketonaemia.

Rofe, A M, Williamson, D H

The effects of vasopressin on the metabolism of starved rats were investigated by using a constant-infusion regimen (50 pmol/kg body wt. per min, after an initial loading dose of 150 pmol/kg body...

The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol.

Bais, R, James, H M, Rofe, A M, Conyers, R A

Ketohexokinase (EC 2.7.1.3) was purified to homogeneity from human liver, and fructose-bisphosphate aldolase (EC 4.1.2.13) was partially purified from the same source. Ketohexokinase was shown, by...

Ketone-body metabolism in tumour-bearing rats.

Rofe, A M, Bais, R, Conyers, R A

During starvation for 72 h, tumour-bearing rats showed accelerated ketonaemia and marked ketonuria. Total blood [ketone bodies] were 8.53 mM and 3.34 mM in tumour-bearing and control...

Mechanism for the 'anti-lipolytic' action of vasopressin in the starved rat.

Rofe, A M, Williamson, D H

The marked decrease in blood non-esterified fatty acids and ketone bodies after vasopressin infusion into starved rats [Rofe & Williamson (1983) Biochem. J. 212, 231-239] was investigated....

Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice.

Rofe, A M, Philcox, J C, Coyle, P

Accumulation of hepatic zinc via metallothionein (MT) induction during infection/inflammation is postulated to benefit a range of metabolic processes. The metabolic consequences of two doses of...

Nutrition and cancer.

Conyers, R A, Need, A G, Rofe, A M, Potezny, N, Kimber, R J

The metabolic response of tumour-bearing mice to fasting.

Rofe, A. M., Porter, S. J., Bais, R., Conyers, R. A.

The suggestion that the ketonaemic response to fasting may be altered in the tumour-bearing state was investigated by studying the metabolism of fasted C57/BL6j mice bearing transplanted B16...

Metallothionein in human oesophagus, Barrett's epithelium and adenocarcinoma

Coyle, P, Mathew, G, Game, P A, Myers, J C, Philcox, J C, Rofe, A M, ...

The potential of the metal-binding protein, metallothionein, in assessing the progression of normal oesophagus through Barrett's to adenocarcinoma was investigated. Metallothionein was quantitatively...

A. M. Rofe

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