A. Messerschmidt

Contribution of globular death domains and unstructured linkers to MyD88(.)IRAK-4 heterodimer formation: An explanation for the antagonistic activity of MyD88s (2009)

Mendoza-Barbera, E., Corral-Rodriguez, M. A., Soares-Schanoski, A., Velarde, M., Macieira, S., Messerschmidt, A., ...

Crystal Structure and Putative Mechanism of 3-Methylitaconate-Delta-isomerase from Eubacterium barkeri (2009)

Velarde, M., Macieira, S., Hilberg, M., Broker, G., Tu, S. M., Golding, B. T., ...

Crystal structure of a trapped phosphate intermediate in vanadium apochloroperoxidase catalyzing a dephosphorylation reaction (2008)

Renirie, R., Wever, R., Messerschmidt, A.

Binding and reduction of sulfite by cytochrome c nitrite reductase (2008)

Lukat, P., Rudolf, M., Stach, P., Messerschmidt, A., Kroneck, P. M. H., Simon, J., ...

Phosphorylation of the human full-length protein kinase C iota (2008)

Macek, B., Benda, C., Jestel, A., Maskos, K., Mann, M., Messerschmidt, A.

Binding and Reduction of Sulfite by Cytochrome c Nitrite Reductase (2008)

P. Lukat, M. Rudolf, P. Stach, A. Messerschmidt, ...

Journal article

Crystal structure of a trapped phosphate intermediate in vanadium apochloroperoxidase catalyzing a dephosphorylation reaction (2008)

Macedo-Ribeiro, S. De, Renirie, R., Wever, R., Messerschmidt, A.

The crystal structure of the apo form of vanadium chloroperoxidase from Curvularia inaequalis reacted with para-nitrophenylphosphate was determined at a resolution of 1.5 Å. The aim of this study...

Functional definition of the tobacco protoporphyrinogen IX oxidase substrate-binding site (2007)

Heinemann, I. U., Diekmann, N., Masoumi, A., Koch, M., Messerschmidt, A., Jahn, M., ...

Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin (2007)

Velarde, M., Huber, R., Yanagisawa, S., Dennison, C., Messerschmidt, A.

Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin (2007)

Velarde, M., Huber, R., Yanagisawa, S., Dennison, C., Messerschmidt, A.

Basic requirements for a metal-binding site in a protein: The influence of loop shortening on the cupredoxin azurin (2006)

Li, C., Yanagisawa, S., Martins, B. M., Messerschmidt, A., Banfield, M. J., Dennison, C.

Eukaryotic expression: developments for structural proteomics (2006)

Aricescu, A. R., Assenberg, R., Bill, R. M., Busso, D., Chang, V. T., Davis, S. J., ...

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value (2006)

Banci, L., Bertini, I., Cusack, S., De Jong, R. N., Heinemann, U., Jones, E. Y., ...

SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects (2006)

Berry, I. M., Dym, O., Esnouf, R. M., Harlos, K., Meged, R., Perrakis, A., ...

Crystal structures of human tissue kallikrein 4: Activity modulation by a specific zinc binding site (2006)

Debela, M., Magdolen, V., Grimminger, V., Sommerhoff, C., Messerschmidt, A., Huber, R., ...

Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism (2005)

Boll,M., Schink,B., Messerschmidt,A., Kroneck,P. M. H.

Radical-mediated dehydration reactions in anaerobic bacteria (2005)

Buckel,W., Martins,B. M., Messerschmidt,A., Golding,B. T.

Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif (2005)

Messerschmidt,A., Macieira,S., Velarde,M., Badeker,M., Benda,C., Jestel,A., ...

Crystal structures of oxidized and reduced stellacyanin from horseradish roots (2005)

Koch,M., Velarde,M., Harrison,M. D., Echt,S., Fischer,M., Messerschmidt,A., ...

Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans (2005)

Martins,B. M., Macedo-Ribeiro,S., Bresser,J., Buckel,W., Messerschmidt,A.

Crystal structures of oxidized and reduced stellacyanin from horseradish roots (2005)

Koch, M., Velarde, M., Harrison, M. D., Echt, S., Fischer, M., Messerschmidt, A., ...

Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans (2005)

Martins, B. M., Macedo-Ribeiro, S., Bresser, J., Buckel, W., Messerschmidt, A.

Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif (2005)

Messerschmidt, A., Macieira, S., Velarde, M., Badeker, M., Benda, C., Jestel, A., ...

Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism (2005)

Boll, M., Schink, B., Messerschmidt, A., Kroneck, P. M. H.

Radical-mediated dehydration reactions in anaerobic bacteria (2005)

Buckel, W., Martins, B. M., Messerschmidt, A., Golding, B. T.

Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase from Pelobacter acetylenicus (2005)

Einsle, O., Niessen, H., Abt, D. J., Seiffert, G., Schink, B., Huber, R., ...

Novel bacterial molybdenum and tungsten enzymes : three-dimensional structure, spectroscopy, and reaction mechanism (2005)

Boll, M., Schink, Bernhard, Messerschmidt, A., Kroneck, Peter M.

The molybdenum enzymes 4-hydroxybenzoyl-CoA reductase and pyrogallol-phloroglucinol transhydroxylase and the tungsten enzyme acetylene hydratase catalyze reductive dehydroxylation reactions, i.e.,...

Crystal structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe-4S] cluster and flavin (2004)

Martins,B. M., Dobbek,H., Cinkaya,I., Buckel,W., Messerschmidt,A.

Crystal structure of pyrogallol-phloroglucinol transhydroxylase, an Mo enzyme capable of intermolecular hydroxyl transfer between phenols (2004)

Messerschmidt,A., Niessen,H., Abt,D., Einsle,O., Schink,B., Kroneck,P. M. H.

Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis (2004)

Koch,M., Breithaupt,C., Kiefersauer,R., Freigang,J., Huber,R., Messerschmidt,A.

Crystal structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe-4S] cluster and flavin (2004)

Martins, B. M., Dobbek, H., Cinkaya, I., Buckel, W., Messerschmidt, A.

Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis (2004)

Koch, M., Breithaupt, C., Kiefersauer, R., Freigang, J., Huber, R., Messerschmidt, A.

Crystal structure of pyrogallol-phloroglucinol transhydroxylase, an Mo enzyme capable of intermolecular hydroxyl transfer between phenols (2004)

Messerschmidt, A., Niessen, H., Abt, D., Einsle, O., Schink, B., Kroneck, P. M. H.

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzyme family: Crystal structure of cystathionine γ-lyase from yeast and intrafamiliar structure comparison (2003)

Messerschmidt,A., Worbs,M., Steegborn,C., Wahl,M. C., Huber,R., Laber,B., ...

The crystal structure of cystathionine [gamma]lyase (CGL) from yeast has been solved by molecular replacement at a resolution of 2.6 a. The molecule consists of 393 amino acid residues and one PLP...

Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzyme family: Crystal structure of cystathionine γ-lyase from yeast and intrafamiliar structure comparison (2003)

Messerschmidt, A., Worbs, M., Steegborn, C., Wahl, M. C., Huber, R., Laber, B., ...

The crystal structure of cystathionine [gamma]lyase (CGL) from yeast has been solved by molecular replacement at a resolution of 2.6 a. The molecule consists of 393 amino acid residues and one PLP...

Determinants of Enzymatic Specificity in the Cys-Met Metabolism PLP-Dependent Enzyme Family: Crystal Structure of Cystathionine g-Lyase from Yeast and Intrafamiliar Structure Comparison (2003)

Messerschmidt, A., Worbs, M., Steegborn, C., Wahl, M. C., Huber, R., Laber, B., ...

Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase (2002)

Einsle,O., Messerschmidt,A., Huber,R., Kroneck,P. M. H., Neese,F.

Cytochrome c nitrite reductase catalyzes the six-electron reduction of nitrite to ammonia without the release of potential reaction intermediates, such as NO or hydroxylamine. On the basis of the...

Structure and function of threonine synthase from yeast (2002)

Garrido-Franco,M., Ehlert,S., Messerschmidt,A., Marinkovic,S., Huber,R., Laber,B., ...

Threonine synthase catalyzes the final step of threonine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-phosphohomoserine into threonine and inorganic phosphate. Threonine...

Crystallization and preliminary X-ray analysis of the membrane-bound cytochrome c nitrite reductase complex (NrfHA) from Wolinella succinogenes (2002)

Einsle,O., Stach,P., Messerschmidt,A., Klimmek,O., Simon,J., Kröger,A., ...

Crystals of the complex between the enzyme cytochrome c nitrite reductase (NrfA) and the membrane-bound quinol oxidase and electron carrier NrfH were grown by vapour diffusion using ammonium sulfate...

Crystallization and preliminary X-ray analysis of the molybdenum-dependent pyrogallol-phloroglucinol transhydroxylase of Pelobacter acidigallici (2002)

Abt,D. J., Einsle,O., Niessen,H., Krieger,R., Messerschmidt,A., Schink,B., ...

Crystals of the molybdo-/iron-sulfur protein pyrogallol:phloroglucinol hydroxyltransferase (transhydroxylase; EC 1.97.1.2) from Pelobacter acidigallici were grown by vapour diffusion in an N-2/H-2...

Dramatic modulation of electron transfer in protein complexes by crosslinking (2002)

Ubbink,M., Einsle,O., Messerschmidt,A., Merli,A., Cavazzini,D., ...

The transfer of electrons between proteins is an essential step in biological energy production. Two protein redox partners are often artificially crosslinked to investigate the poorly understood...

Crystallization and preliminary X-ray analysis of the membrane-bound cytochrome c nitrite reductase complex (NrfHA) from Wolinella succinogenes (2002)

Einsle, O., Stach, P., Messerschmidt, A., Klimmek, O., Simon, J., Kröger, A., ...

Crystals of the complex between the enzyme cytochrome c nitrite reductase (NrfA) and the membrane-bound quinol oxidase and electron carrier NrfH were grown by vapour diffusion using ammonium sulfate...

Crystallization and preliminary X-ray analysis of the molybdenum-dependent pyrogallol-phloroglucinol transhydroxylase of Pelobacter acidigallici (2002)

Abt, D. J., Einsle, O., Niessen, H., Krieger, R., Messerschmidt, A., Schink, B., ...

Crystals of the molybdo-/iron-sulfur protein pyrogallol:phloroglucinol hydroxyltransferase (transhydroxylase; EC 1.97.1.2) from Pelobacter acidigallici were grown by vapour diffusion in an N-2/H-2...

Dramatic modulation of electron transfer in protein complexes by crosslinking (2002)

Ubbink, M., Einsle, O., Messerschmidt, A., Merli, A., Cavazzini, D., ...

The transfer of electrons between proteins is an essential step in biological energy production. Two protein redox partners are often artificially crosslinked to investigate the poorly understood...

Structure and function of threonine synthase from yeast (2002)

Garrido-Franco, M., Ehlert, S., Messerschmidt, A., Marinkovic, S., Huber, R., Laber, B., ...

Threonine synthase catalyzes the final step of threonine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-phosphohomoserine into threonine and inorganic phosphate. Threonine...

Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase (2002)

Einsle, O., Messerschmidt, A., Huber, R., Kroneck, P. M. H., Neese, F.

Cytochrome c nitrite reductase catalyzes the six-electron reduction of nitrite to ammonia without the release of potential reaction intermediates, such as NO or hydroxylamine. On the basis of the...

X-ray crystal structures of active site mutants of the vanadium-containing chloroperoxidase from the fungus Curvularia inaequalis (1999)

Macedo-Ribeiro, S., Hemrika, W., Renirie, R., Wever, R., Messerschmidt, A.

Heterologous expression of the vanadium-containing chloroperoxidase from Curvularia inaequalis in Saccharomyces cerevisiae and site-directed mutagenesis of the active site residues His496, Lys353, Arg360 and Arg490 (1999)

Hemrika, W., Renirie, R., Macedo-Ribeiro, S., Messerschmidt, A., Wever, R.

X ray structures of apo- and tungstate derivatives of vanadium chloroperoxidase from the fungus Curvularia inaequalis (1998)

Messerschmidt, A., Wever, R.

From vanadium chloroperoxidases to phosphatases, the same architecture for the active site (1997)

Wever, R., Hemrika, W., Renirie, R., Barnett, P., Messerschmidt, A., Dekker, H.L.

X-ray structures of the native and peroxide form of the vanadium-containing enzyme chloroperoxidase from the fungus Curvularia inaequalis (1997)

Messerschmidt, A., Prade, P., Wever, R.

Implications for the catalytic mechanism of the vanadium-containing enzyme chloroperoxidase from the fungus Curvularia inaequalis by x-ray structures of the native and peroxide form (1997)

Messerschmidt, A., Prade, P, Wever, R.

The mutation Met121His creates a type-1.5 copper site in Alcaligenes denitrificans azurin. (1996)

Kroes, S.J., Hoitink, C.W.G., Andrew, C.R., Ai, J., Sanders-Loehr, J., Messerschmidt, A., ...

First X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis. (1996)

Messerschmidt, A., Wever, R.

Vanadium peroxidases: structure and function. (1995)

Wever, R., Barnett, P., Simons, L.H., Messerschmidt, A., Hemrika, W.

X-ray structure of a vandium-containing chloroperoxidase from the fungus Curvularia inaequalis (1995)

Messerschmidt, A., Wever, R.

Primary structure, characterization and expression of the vanadium chloroperoxidase from the fungus Curvularia tnaequalis (1995)

Simons, B.H., Barnett, P., Vollenbroek, E.G.M., Dekker, H.L., Muijsers, A.O., Messerschmidt, A., ...

X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis.

Messerschmidt, A, Wever, R

The chloroperoxidase (EC 1.11.1.-) from the fungus Curvularia inaequalis belongs to a class of vanadium enzymes that oxidize halides in the presence of hydrogen peroxide to the corresponding...

Kinetic features of ascorbic acid oxidase after partial deglycation.

D'Andrea, G, Maccarrone, M, Oratore, A, Avigliano, L, Messerschmidt, A

By means of specific exoglycosidases, sugars have been removed under non-denaturing conditions from ascorbic acid oxidase (AAO), different deglycation schedules being followed. Our results indicate...

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.

Clausen, T, Huber, R, Prade, L, Wahl, M C, Messerschmidt, A

The transsulfuration enzyme cystathionine gamma-synthase (CGS) catalyses the pyridoxal 5'-phosphate (PLP)-dependent gamma-replacement of O-succinyl-L-homoserine and L-cysteine, yielding...

X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis.

Messerschmidt, A, Wever, R

The chloroperoxidase (EC 1.11.1.-) from the fungus Curvularia inaequalis belongs to a class of vanadium enzymes that oxidize halides in the presence of hydrogen peroxide to the corresponding...

Kinetic features of ascorbic acid oxidase after partial deglycation.

D'Andrea, G, Maccarrone, M, Oratore, A, Avigliano, L, Messerschmidt, A

By means of specific exoglycosidases, sugars have been removed under non-denaturing conditions from ascorbic acid oxidase (AAO), different deglycation schedules being followed. Our results indicate...

Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.

Clausen, T, Huber, R, Prade, L, Wahl, M C, Messerschmidt, A

The transsulfuration enzyme cystathionine gamma-synthase (CGS) catalyses the pyridoxal 5'-phosphate (PLP)-dependent gamma-replacement of O-succinyl-L-homoserine and L-cysteine, yielding...