Primary biliary cirrhosis, cutaneous capillaritis, and IgM-associated membranous glomerulonephritis.
Hamlyn, A N, Gollan, J L, Douglas, A P, Sherlock, S
Two girls, aged 12 and 17 years, presented with hepatocellular dysfunction and severe haemolysis due to Wilson's disease (hepatolenticular degeneration). This was accompanied by acute renal failure....
Primary biliary cirrhosis, cutaneous capillaritis, and IgM-associated membranous glomerulonephritis.
Hamlyn, A N, Gollan, J L, Douglas, A P, Sherlock, S
Two girls, aged 12 and 17 years, presented with hepatocellular dysfunction and severe haemolysis due to Wilson's disease (hepatolenticular degeneration). This was accompanied by acute renal failure....
Open access fibresigmoidoscopy: a comparative audit of efficacy
Kalra, L, Price, W R, Jones, B J M, Hamlyn, A N
A total of 541 open access referrals for fibresigmoidoscopy over five years were compared with 495 hospital initiated procedures during the same period. The number of open access fibresigmoidoscopies...
Chronic laxative abuse associated with pancreatic islet cell hyperplasia.
Lesna, M, Hamlyn, A N, Venables, C W, Record, C O
Marked pancreatic islet cell hyperplasia was found in a patient with laxative-induced diarrhoea. It is suggested that laxative abuse might be an important aetiological factor in patients with...
The epidemiology of primary biliary cirrhosis: A survey of mortality in England and Wales
Primary biliary cirrhosis is a rare disease in the general population. Estimates of its true incidence are difficult but since survival time is unaffected by treatment, mortality may reflect...
ABO blood groups, Rhesus negativity, and primary biliary cirrhosis
Hamlyn, A. N., Morris, J. S., Sherlock, S.
The distribution of blood groups and Rhesus negativity in 91 British patients with primary biliary cirrhosis was compared with a sample of registered blood donors. There were no significant...
Haemagglutinating anti-actin antibodies in acute and chronic liver disease
Anti-actin antibody was measured by the passive haemagglutination test in the serum of 118 patients with various forms of chronic cholestatic and non-cholestatic liver disease, and of 23 patients...
Primary biliary cirrhosis: geographical clustering and symptomatic onset seasonality.
Hamlyn, A N, Macklon, A F, James, O
Patients with primary biliary cirrhosis (primary non-suppurative destructive cholangitis) in the north east region of England were studied over a five year period and, to evaluate epidemicity,...
Effect of ornithine alpha oxoglutarate on brain metabolism in patients with chronic liver disease.
James, I M, Hamlyn, A N, Brant, P C, Hildrew, P
Patients with chronic liver disease, yet without severe encephalopathy, were found to show evidence of increased brain utilization of glucose. The changes were abolished after an intravenous infusion...
The spectrum of paracetamol (acetaminophen) overdose: clinical and epidemiological studies.
Hamlyn, A. N., Douglas, A. P., James, O.
In a regional survey of paracetamol overdose, 201 patients were admitted to hospital over 12 months. Chronic alcoholism was present in 10% of cases. Over 25% of patients were females aged 20 years or...
Comparative evaluation of investigations for colorectal carcinoma in symptomatic patients.
We studied 154 patients presenting with significant colonic symptoms and subsequently diagnosed to have colorectal carcinoma. They were investigated by faecal occult blood tests, fibresigmoidoscopy,...
Possible genetic influences in familial sarcoidosis
James, D. Geraint, Piyasena, K. H. G., Neville, E., Walker, A. N., Hamlyn, A. N.
Five families (three English, one Irish, one West Indian) contained eleven members with sarcoidosis, nine of whom have been investigated and followed. Their multisystem involvement and course was...
Caroli's disease with intrahepatic gall-stones and salmonella infection.
Hamlyn, A. N., James, O. F., Douglas, A. P., Lavelle, M. I., Venables, C. W.
At operation for small bowel intussusception, a 26-year-old man was found to have an enlarged liver and spleen. Subsequent investigations suggested bile passage infection associated with numerous...
Open access fibresigmoidoscopy: a comparative audit of efficacy
Kalra, L, Price, W R, Jones, B J M, Hamlyn, A N
A total of 541 open access referrals for fibresigmoidoscopy over five years were compared with 495 hospital initiated procedures during the same period. The number of open access fibresigmoidoscopies...