A. Novelletto

Publication List Details

Period

1969 - 2005

Number

25

Co-Authors

The trinucleotide repeat expansion on chromosome 6p (SCA1) in autosomal dominant cerebellar ataxias (1994)

Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., ...

Affected members of 73 families with a variety of autosomal dominant late onset cerebellar ataxias (ADCAs) were investigated for the trinucleotide (CAG) repeat expansion which is found in pedigrees...

Differential structuring of human populations for homologous X and Y microsatellite loci.

Scozzari, R, Cruciani, F, Malaspina, P, Santolamazza, P, Ciminelli, B M, Torroni, A, ...

The global pattern of variation at the homologous microsatellite loci DYS413 (Yq11) and DXS8174 and DXS8175 (Xp22) was analyzed by examination of 30 world populations from four continents, accounting...

Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria).

Chambliss, K L, Hinson, D D, Trettel, F, Malaspina, P, Novelletto, A, Jakobs, C, ...

Succinic semialdehyde dehydrogenase (SSADH) deficiency, a rare metabolic disorder of 4-aminobutyric acid degradation, has been identified in approximately 150 patients. Affected individuals...

Network analyses of Y-chromosomal types in Europe, northern Africa, and western Asia reveal specific patterns of geographic distribution.

Malaspina, P, Cruciani, F, Ciminelli, B M, Terrenato, L, Santolamazza, P, Alonso, A, ...

In a study of 908 males from Europe, northern Africa, and western Asia, the variation of four Y-linked dinucleotide microsatellites was analyzed within three "frames" that are defined by mutations...

Combined use of biallelic and microsatellite Y-chromosome polymorphisms to infer affinities among African populations.

Scozzari, R, Cruciani, F, Santolamazza, P, Malaspina, P, Torroni, A, Sellitto, D, ...

To define Y-chromosome haplotypes, we studied seven biallelic polymorphic sites. We combined data with those from four dinucleotide-repeat polymorphisms, to establish Y-chromosome compound...

The Geographic Distribution of Human Y Chromosome Variation

Hammer, M. F., Spurdle, A. B., Karafet, T., Bonner, M. R., Wood, E. T., Novelletto, A., ...

We examined variation on the nonrecombining portion of the human Y chromosome to investigate human evolution during the last 200,000 years. The Y-specific polymorphic sites included the Y Alu...

Protection against malaria morbidity: Near-fixation of the α-thalassemia gene in a Nepalese population

Modiano, G., Morpurgo, G., Terrenato, L., Novelletto, A., Di Rienzo, A., Colombo, B., ...

We have previously reported that the Tharu people of the Terai region in southern Nepal have an incidence of malaria about sevenfold lower than that of synpatric non-Tharu people. In order to find...

Molecular basis for HbH disease in Italy: geographical distribution of deletional and nondeletional alpha-thalassemia haplotypes.

Di Rienzo, A, Novelletto, A, Aliquò, M C, Bianco, I, Tagarelli, A, Brancati, C, ...

We have investigated the molecular basis for HbH disease in 16 patients from Sardinia, and central and southern Italy. We have shown that HbH disease is produced by the interaction of at least 10...

The Geographic Distribution of Human Y Chromosome Variation

Hammer, M. F., Spurdle, A. B., Karafet, T., Bonner, M. R., Wood, E. T., Novelletto, A., ...

We examined variation on the nonrecombining portion of the human Y chromosome to investigate human evolution during the last 200,000 years. The Y-specific polymorphic sites included the Y Alu...

Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria).

Chambliss, K L, Hinson, D D, Trettel, F, Malaspina, P, Novelletto, A, Jakobs, C, ...

Succinic semialdehyde dehydrogenase (SSADH) deficiency, a rare metabolic disorder of 4-aminobutyric acid degradation, has been identified in approximately 150 patients. Affected individuals...

Network analyses of Y-chromosomal types in Europe, northern Africa, and western Asia reveal specific patterns of geographic distribution.

Malaspina, P, Cruciani, F, Ciminelli, B M, Terrenato, L, Santolamazza, P, Alonso, A, ...

In a study of 908 males from Europe, northern Africa, and western Asia, the variation of four Y-linked dinucleotide microsatellites was analyzed within three "frames" that are defined by mutations...

Combined use of biallelic and microsatellite Y-chromosome polymorphisms to infer affinities among African populations.

Scozzari, R, Cruciani, F, Santolamazza, P, Malaspina, P, Torroni, A, Sellitto, D, ...

To define Y-chromosome haplotypes, we studied seven biallelic polymorphic sites. We combined data with those from four dinucleotide-repeat polymorphisms, to establish Y-chromosome compound...

Protection against malaria morbidity: Near-fixation of the α-thalassemia gene in a Nepalese population

Modiano, G., Morpurgo, G., Terrenato, L., Novelletto, A., Di Rienzo, A., Colombo, B., ...

We have previously reported that the Tharu people of the Terai region in southern Nepal have an incidence of malaria about sevenfold lower than that of synpatric non-Tharu people. In order to find...

Molecular basis for HbH disease in Italy: geographical distribution of deletional and nondeletional alpha-thalassemia haplotypes.

Di Rienzo, A, Novelletto, A, Aliquò, M C, Bianco, I, Tagarelli, A, Brancati, C, ...

We have investigated the molecular basis for HbH disease in 16 patients from Sardinia, and central and southern Italy. We have shown that HbH disease is produced by the interaction of at least 10...

Differential structuring of human populations for homologous X and Y microsatellite loci.

Scozzari, R, Cruciani, F, Malaspina, P, Santolamazza, P, Ciminelli, B M, Torroni, A, ...

The global pattern of variation at the homologous microsatellite loci DYS413 (Yq11) and DXS8174 and DXS8175 (Xp22) was analyzed by examination of 30 world populations from four continents, accounting...

CAG repeat instability, cryptic sequence variation and pathogeneticity: evidence from different loci.

Frontali, M, Novelletto, A, Annesi, G, Jodice, C

Different aspects of expanded polyglutamine tracts and of their pathogenetic role are taken into consideration here. (i) The (CAG)n length of wild-type alleles of the Huntington disease gene was...

Effect of trinucleotide repeat length and parental sex on phenotypic variation in spinocerebellar ataxia I.

Jodice, C., Malaspina, P., Persichetti, F., Novelletto, A., Spadaro, M., Giunti, P., ...

Trinucleotide repeat expansion has been found in 64 subjects from 19 families: 57 patients with SCA1 and 7 subjects predicted, by haplotype analysis, to carry the mutation. Comparison with a large...