Fitoussi, F., Arlet, G., Grimont, P. A. D., Lagrange, Ph., Philippon, A.
The susceptibility pattern of Escherichia hermannii, although closely related to Escherichia coli according to its biochemical patterns, was clearly distinguishable by its susceptibility to...
Characterization of a {beta}-lactamase from Clostridium clostridioforme (1994)
Appelbaum, P. C., Spangler, S. K., Pankuch, G. A., Philippon, A., Jacobs, M. R., Shiman, R., ...
A β-lactamase-producing strain of Clostridium clostridioforme isolated from human peritoneal fluid was examined by MIC testing and enzyme characterization. MICs of penicillins (64–512 mg/L)...
Videl, G., Belaaouaj, A., Gilly, L., Labia, R., Philippon, A., Névot, P., ...
Two different strains of Eschtrichia coli exhibiting unusual patterns of resistance to β-lactam antibiotics were isolated from patients at Cochin Hospital. Both isolates showed a low level of...
Shannon, K. P., King, A., Phillips, I., Nicolas, M. H., Philippon, A.
We report the isolation of three strains of Klebsiella pneumoniae sensu lato, brought into the United Kingdom by patients from Greece and Egypt, that showed plasmid-determined resistance to...
Vatopoulos, A. C., Philippon, A., Tzouvelekis, L. S., Komninou, Z., Legakis, N. J.
Analysis with a double-disc synergy test (DDST) of clinical isolates of Klebsiella pneumoniae and Escherichia coli during the period October 1988-September 1989 revealed that 24% of the former...
Vedel, G., Picard, B., Paul, G., Philippon, A., Gilly, L., Krishnamoorthy, R., ...
Six β-lactamases from Klebsiella pneumoniae, five of which (SHV-1, SHV-2, SHV-3, SHV-4 and SHV-5) were plasmid-encoded and one which (βla GN 11–03) was chromosomally-encoded, were compared by...
Joly-Guillo, M. L., Vallée, E., Bergogne-Bérézin, E., Philippon, A.
One hundred clinical strains of Acinetobacter calcoaceticus isolated from 1981 to 1986 were screened for enzymatic resistance to β-lactam antibiotics. Fourteen β-antibiotics were tested and four...
Labia, R., Guionie, M., Barthélémy, M., Philippon, A.
Three Pseudomonas aeruginosa strains, isolated in Cochin Hospital (Paris), produced constitutive β-lactamases markedly active against carbenicillin (high Vm) which have been designated as...
Decré, D, Arlet, G, Bergogne-Bérézin, E, Philippon, A
Eleven strains of Alcaligenes denitrificans subsp. xylosoxydans produced a beta-lactamase with a pI of 5.7 with kinetic data characteristic of a PSE-1-type enzyme. A CARB-type enzyme was identified...
Fournier, B, Lu, C Y, Lagrange, P H, Krishnamoorthy, R, Philippon, A
Klebsiella oxytoca mutants resistant to a variety of beta-lactams were obtained in vitro on aztreonam. Constitutive beta-lactamase production was much higher in the mutants than in the susceptible...
Fournier, B, Roy, P H, Lagrange, P H, Philippon, A
The chromosomally encoded beta-lactamase gene (blaOXY-2) of the wild-type Klebsiella oxytoca SL911 was cloned and sequenced. Its nucleotide sequence similarity with the previously sequenced K....
beta-lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca.
Fournier, B, Lagrange, P H, Philippon, A
beta-Lactamase gene promoters of 45 clinical Klebsiella oxytoca isolates resistant to beta-lactams and exhibiting beta-lactamase hyperproduction differed from those in 26 susceptible strains. Direct...
Fantin, B, Pangon, B, Potel, G, Caron, F, Vallée, E, Vallois, J M, ...
We studied the efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ceftriaxone in vitro and in experimental endocarditis due to an Escherichia coli strain producing an...
Appelbaum, P C, Philippon, A, Jacobs, M R, Spangler, S K, Gutmann, L
Twelve beta-lactamase-positive non-Bacteroides fragilis group Bacteroides spp. belonging to seven different species were examined by MIC determination and enzyme characterization. MICs of most...
Nicolas, M H, Jarlier, V, Honore, N, Philippon, A, Cole, S T
In Klebsiella pneumoniae 86-4, cefotaxime resistance was due to a transferable broad-spectrum beta-lactamase, SHV-3. The plasmid-borne gene encoding SHV-3 has been cloned, and the primary structure...
Nicolas, M H, Honore, N, Jarlier, V, Philippon, A, Cole, S T
Two strains of Enterobacter cloacae were isolated from a patient before (strain MHN1) and during (strain MHN2) treatment with moxalactam and gentamicin. Strain MHN1 exhibited inducible ampC...
Arlet, G, Rouveau, M, Fournier, G, Lagrange, P H, Philippon, A
A clinical isolate of Klebsiella pneumoniae was more resistant to aztreonam than to cefotaxime and ceftazidime. It produced a clavulanate-susceptible beta-lactamase with an isoelectric point of 6.3...
Plasmid-mediated ROB-1 beta-lactamase in Pasteurella multocida from a human specimen.
Rosenau, A, Labigne, A, Escande, F, Courcoux, P, Philippon, A
A Pasteurella multocida human isolate was resistant to beta-lactams because of production of ROB-1 beta-lactamase. The beta-lactamase was encoded by a 4.3-kb plasmid closely related to that of a...
Bingen, E H, Desjardins, P, Arlet, G, Bourgeois, F, Mariani-Kurkdjian, P, Lambert-Zechovsky, N Y, ...
Over a 12-month period, 43 children in eight different wards of our hospital (Hôpital Robert Debré) were infected or colonized with Klebsiella pneumoniae strains producing extended broad-spectrum...
Arlet, G, Rouveau, M, Casin, I, Bouvet, P J, Lagrange, P H, Philippon, A
Preliminary results suggested that the diffusion in France of the SHV-4 extended-spectrum beta-lactamase was probably due to the spread of one single epidemic strain of Klebsiella pneumoniae. In this...
Eckert, C., Gautier, V., Saladin-Allard, M., Hidri, N., Verdet, C., Ould-Hocine, Z., ...
We analyzed 19 clinical isolates of the family Enterobacteriaceae (16 Escherichia coli isolates and 3 Klebsiella pneumoniae isolates) collected from four different hospitals in Paris, France, from...
Decré, D, Arlet, G, Bergogne-Bérézin, E, Philippon, A
Eleven strains of Alcaligenes denitrificans subsp. xylosoxydans produced a beta-lactamase with a pI of 5.7 with kinetic data characteristic of a PSE-1-type enzyme. A CARB-type enzyme was identified...
Fournier, B, Lu, C Y, Lagrange, P H, Krishnamoorthy, R, Philippon, A
Klebsiella oxytoca mutants resistant to a variety of beta-lactams were obtained in vitro on aztreonam. Constitutive beta-lactamase production was much higher in the mutants than in the susceptible...
Fournier, B, Roy, P H, Lagrange, P H, Philippon, A
The chromosomally encoded beta-lactamase gene (blaOXY-2) of the wild-type Klebsiella oxytoca SL911 was cloned and sequenced. Its nucleotide sequence similarity with the previously sequenced K....
beta-lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca.
Fournier, B, Lagrange, P H, Philippon, A
beta-Lactamase gene promoters of 45 clinical Klebsiella oxytoca isolates resistant to beta-lactams and exhibiting beta-lactamase hyperproduction differed from those in 26 susceptible strains. Direct...
Fantin, B, Pangon, B, Potel, G, Caron, F, Vallée, E, Vallois, J M, ...
We studied the efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ceftriaxone in vitro and in experimental endocarditis due to an Escherichia coli strain producing an...
Appelbaum, P C, Philippon, A, Jacobs, M R, Spangler, S K, Gutmann, L
Twelve beta-lactamase-positive non-Bacteroides fragilis group Bacteroides spp. belonging to seven different species were examined by MIC determination and enzyme characterization. MICs of most...
Nicolas, M H, Jarlier, V, Honore, N, Philippon, A, Cole, S T
In Klebsiella pneumoniae 86-4, cefotaxime resistance was due to a transferable broad-spectrum beta-lactamase, SHV-3. The plasmid-borne gene encoding SHV-3 has been cloned, and the primary structure...
Nicolas, M H, Honore, N, Jarlier, V, Philippon, A, Cole, S T
Two strains of Enterobacter cloacae were isolated from a patient before (strain MHN1) and during (strain MHN2) treatment with moxalactam and gentamicin. Strain MHN1 exhibited inducible ampC...
Arlet, G, Rouveau, M, Fournier, G, Lagrange, P H, Philippon, A
A clinical isolate of Klebsiella pneumoniae was more resistant to aztreonam than to cefotaxime and ceftazidime. It produced a clavulanate-susceptible beta-lactamase with an isoelectric point of 6.3...
Plasmid-mediated ROB-1 beta-lactamase in Pasteurella multocida from a human specimen.
Rosenau, A, Labigne, A, Escande, F, Courcoux, P, Philippon, A
A Pasteurella multocida human isolate was resistant to beta-lactams because of production of ROB-1 beta-lactamase. The beta-lactamase was encoded by a 4.3-kb plasmid closely related to that of a...
Bingen, E H, Desjardins, P, Arlet, G, Bourgeois, F, Mariani-Kurkdjian, P, Lambert-Zechovsky, N Y, ...
Over a 12-month period, 43 children in eight different wards of our hospital (Hôpital Robert Debré) were infected or colonized with Klebsiella pneumoniae strains producing extended broad-spectrum...
Arlet, G, Rouveau, M, Casin, I, Bouvet, P J, Lagrange, P H, Philippon, A
Preliminary results suggested that the diffusion in France of the SHV-4 extended-spectrum beta-lactamase was probably due to the spread of one single epidemic strain of Klebsiella pneumoniae. In this...
Eckert, C., Gautier, V., Saladin-Allard, M., Hidri, N., Verdet, C., Ould-Hocine, Z., ...
We analyzed 19 clinical isolates of the family Enterobacteriaceae (16 Escherichia coli isolates and 3 Klebsiella pneumoniae isolates) collected from four different hospitals in Paris, France, from...
Genetic Environment of Acquired blaACC-1 β-Lactamase Gene in Enterobacteriaceae Isolates▿
Doloy, A., Verdet, C., Gautier, V., Decré, D., Ronco, E., Hammami, A., ...
We studied the genetic organization of blaACC-1 in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this...