Scientific Commons: A. Purohit

By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent dual aromatase-sulfatase inhibitors (DASIs) were generated. The best...

Dual aromatase-steroid sulfatase inhibitors (2007)

Woo, L.W.L., Bubert, C., Sutcliffe, O.B., Smith, A., Chander, S.K., Mahon, M.F., ...

By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent dual aromatase-sulfatase inhibitors (DASIs) were generated. The best...

E-ring modified steroids as novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (2005)

Fischer, D.S., Allan, G.M., Bubert, C., Vicker, N., Smith, A., Tutill, H.J., ...

17β-Hydroxysteroid dehydrogenases (17β-HSDs) are an important class of steroidogenic enzymes that regulate the bioavailability of active estrogens and androgens and are as yet a relatively...

2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases (2004)

Wood, L., Leese, M.P., Mouzakiti, A., Purohit, A., Potter, B.V., Reed, M.J., ...

2-Methoxyoestradiol (2-MeOE2) is an endogenous oestrogen metabolite which inhibits tubulin polymerisation and has anti-tumour and anti-angiogenic activity. 2-MeOE2 induces apoptosis in a wide range...

Prolapsed Intraocular Aspergilloma Masquerading as Malignant Melanoma (2003)

Bajaj, MS, Pushker, N, Kulkarni, A, Kashyap, S, Purohit, A

Hemangioblastoma: A study of radiopathologic correlation (2003)

Sundaram, C, Rammurti, S, Reddy, J, Prasad, S, Purohit, A

First dual aromatase-steroid sulfatase inhibitors (2003)

Woo, L.W.L., Sutcliffe, O.B.*, Bubert, C., Grasso, A., Chander, S.K., Purohit, A., ...

Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important additional source of tumor estrogen, and blockade of...

First dual aromatase-steroid sulfatase inhibitors (2003)

Woo, L.W.L., Sutcliffe, O.B., Bubert, C., Grasso, A., Chander, S.K., Purohit, A., ...

Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important additional source of tumor estrogen, and blockade of...

Pattern of pediatric ocular trauma in India. (2002)

Saxena, R, Sinha, R, Purohit, A, Dada, T, Vajpayee, RB, Azad, RV

Aneurysmal bone cyst of the temporal bone : a case report. (2002)

Purohit, A, Chopra, S, Sinha, V, Dharker, S

Benign meningioma metastasizing through CSF pathways : a case report and review of literature. (2002)

Ramakrishnamurthy, T, Murty, A, Purohit, A, Sundaram, C

Proctocolectomy with formation of ileal reservoir in a 3-year old child with multiple polyposis coli (2001)

Sharma, K, Purohit, A, Mehta, R

Cysts of the central nervous system : a clinicopathologic study of 145 cases. (2001)

Sundaram, C, Paul, T, Raju, B, Ramakrishna, MT, Sinha, A, Prasad, V, ...

Traumatic distal anterior cerebral artery aneurysm in a child : a case report. (2001)

Raju, B, Purohit, A, Murthy, S, Sundaram, C, Sanjay, T

Serum-ascites albumin gradient : a predictor of esophageal varices with ascites. (2001)

Das, B, Purohit, A, Acharya, U, Treskova, E

Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives - structure-activity relationships (2001)

Wood, L., Leese, M.R., Leblond, B., Woo, L.W., Ganeshapillai, D., Purohit, A., ...

Superoxide dismutases catalyse the dismutation of highly reactive superoxide ions to produce hydrogen peroxide and several lines of evidence suggest that these enzymes play important roles in the...

Duplication Cyst causing ileal atresia : a case report and review of literature (2000)

Sharma, K, Purohit, A

Concealed diphallus :a Case report and review of the literature. (2000)

Sharma, K, Jain, R, Jain, S, Purohit, A

Urinary ascites in a female neonate associated with hypospadias. (2000)

Purohit, A, Sharma, K, Tomar, V

Distal calcarine fusiform aneurysm : a case report and review of literature. (1999)

Ramakrishnamurthy, T, Purohit, A, Sundaram, C, Rajender, Y

CSF orbitorrhoea with tension pneumocephalus. (1999)

Rao, T, Purohit, A, Murthy, T, Dinakar, I

Piper officinarum : a potent antiatherosclerotic and hypolipidaemic agent. (1998)

Sharma, T, Gusain, D, Dixit, V, Purohit, A

Centrosome defects and genetic instability in malignant tumors (1998)

Pihan, G A, Purohit, A, Wallace, J, Knecht, H, Woda, Bruce A., Quesenberry, Peter J., ...

Genetic instability is a common feature of many human cancers. This condition is frequently characterized by an abnormal number of chromosomes, although little is known about the mechanism that...

Bilateral trigonal lateral ventricular mirror image meningiomas : a case report. (1998)

Purohit, A, Reddy, J, Sundaram, C, Jaleel, M, Sahu, B, Sundram, C

Claudicatory penile erection in lumbar canal stenosis with prolapsed disc : a case report of 2 cases. (1997)

Purohit, A, Raju, B, Reddy, J, Dinakar, I

Oculomotor paresis in unruptured anterior communicating artery aneurysm [Letter] (1997)

Purohit, A, Sahu, B, Ramesh, R, Murthy, T, Ramakrishna, M

Speckled lentiginous naevus (1996)

Kalla, G, Purohit, S, Purohit, A, Vyas, M

Ileal trichobezoar in a child presenting as intestinal obstruction : a case report. (1996)

Sharma, K, Purohit, A, Agarawal, P, Gupta, M

Red grain mycetoma foot in Western Rajasthan (1994)

Mathur, D, Prakash, P, Gupta, P, Purohit, A, Vyas, M

Contiguous direct and retrograde intussusception in association with necrotizing enteritis (a case report). (1983)

Rao, K, Purohit, A, Yadav, K, Pathak, I

Eccrine Spiradenoma (1983)

Jha, S, Purohit, A

PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid.

Greisen, K, Loeffelholz, M, Purohit, A, Leong, D

A set of broad-range PCR primers for the 16S rRNA gene in bacteria were tested, along with three series of oligonucleotide probes to detect the PCR product. The first series of probes is broad in...

Vaccination with genetically engineered allergens prevents progression of allergic disease

Niederberger, V., Horak, F., Vrtala, S., Spitzauer, S., Valent, P., ...

IgE-mediated allergy affects >25% of the population in industrialized countries. Repeated contact with the disease-eliciting allergens induces rises of allergen-specific IgE Abs and progression of...

PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid.

Greisen, K, Loeffelholz, M, Purohit, A, Leong, D

A set of broad-range PCR primers for the 16S rRNA gene in bacteria were tested, along with three series of oligonucleotide probes to detect the PCR product. The first series of probes is broad in...

Vaccination with genetically engineered allergens prevents progression of allergic disease

Niederberger, V., Horak, F., Vrtala, S., Spitzauer, S., Valent, P., ...

IgE-mediated allergy affects >25% of the population in industrialized countries. Repeated contact with the disease-eliciting allergens induces rises of allergen-specific IgE Abs and progression of...

Characterization of a guinea-pig lymphokine, macrophage agglutination factor.

Godfrey, H P, Purohit, A

We have previously shown guinea-pig macrophage agglutination factor (MAggF-) to be a high mol. wt (greater than or equal to 150,000) T-cell-dependent lymphokine that is antigenically distinct from...

Reversible binding of a guinea-pig lymphokine to gelatin and fibrinogen: possible relationship of macrophage agglutination factor and fibronectin.

Godfrey, H P, Purohit, A

Macrophage agglutination factor (MAggF) is a T-cell-dependent guinea-pig lymphokine with pH stability, heat stability and isoelectric point similar to fibronectin (see preceeding paper for details)....

Unusual case of residual cortical lens matter in anterior chamber

Prakash, G, Kumar, A, Purohit, A

Comparative activity of cetirizine and mizolastine on histamine-induced skin wheal and flare responses at 24 h

Purohit, A, Mélac, M, Pauli, G, Frossard, N

A. Purohit

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